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- W4229012927 endingPage "2515" @default.
- W4229012927 startingPage "2481" @default.
- W4229012927 abstract "Cyanide is traditionally viewed as a cytotoxic agent, with its primary mode of action being the inhibition of mitochondrial Complex IV (cytochrome c oxidase). However, recent studies demonstrate that the effect of cyanide on Complex IV in various mammalian cells is biphasic: in lower concentrations (nanomolar to low micromolar) cyanide stimulates Complex IV activity, increases ATP production and accelerates cell proliferation, while at higher concentrations (high micromolar to low millimolar) it produces the previously known ('classic') toxic effects. The first part of the article describes the cytotoxic actions of cyanide in the context of environmental toxicology, and highlights pathophysiological conditions (e.g., cystic fibrosis with Pseudomonas colonization) where bacterially produced cyanide exerts deleterious effects to the host. The second part of the article summarizes the mammalian sources of cyanide production and overviews the emerging concept that mammalian cells may produce cyanide, in low concentrations, to serve biological regulatory roles. Cyanide fulfills many of the general criteria as a 'classical' mammalian gasotransmitter and shares some common features with the current members of this class: nitric oxide, carbon monoxide, and hydrogen sulfide." @default.
- W4229012927 created "2022-05-08" @default.
- W4229012927 creator A5058049602 @default.
- W4229012927 creator A5070424783 @default.
- W4229012927 date "2021-08-05" @default.
- W4229012927 modified "2023-09-30" @default.
- W4229012927 title "The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter" @default.
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