Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229013437> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4229013437 endingPage "791" @default.
- W4229013437 startingPage "782" @default.
- W4229013437 abstract "Background: The diagnosis of device infections, especially pocket infections, is challenging and relies primarily on clinical presentation. The prospective DIRT (Device associated Infections Role of new diagnostic Tools) study identified procalcitonin (PCT) as the most promising biomarker among other 14 biomarkers to aid the diagnosis of pocket infection. It also identified an optimized cut-off value of 0.05 ng/ml for a localized generator pocket infection. Aims: The present study aims to validate the proposed PCT cut-off value of 0.05 ng/ml for the diagnosis of pocket infection in an independent cohort. Methods: We prospectively enrolled 81 patients with pocket infections and 81 controls matched for age and renal function presenting for elective device exchange or lead revision. Patients with concomitant infectious or inflammatory diseases, end-stage renal failure, current active malignancy, or receiving immunosuppressive therapy were excluded. Results: An elevated PCT over 0.05 ng/ml was found in 68% (n = 55) of pocket infections and 24% (n = 19) of controls, corresponding to a sensitivity of 68% and a specificity of 77% for diagnosing a pocket infection. In receiver operating characteristic (ROC) analysis, PCT showed an area under the curve of 0.75 (95% confidence interval, 0.68–0.83; P < 0.001). Sensitivity remained high with antibiotic pretreatment (65% compared to 69% without pretreatment) and in cases with minimal inflammatory signs (67% compared to 70% with extensive inflammation). Conclusion: Our study validates the cut-off value of 0.05 ng/ml PCT for diagnosis of a pocket infection, even in patients pre-treated with antibiotics or with minimal clinical signs of inflammation." @default.
- W4229013437 created "2022-05-08" @default.
- W4229013437 creator A5002116007 @default.
- W4229013437 creator A5012539245 @default.
- W4229013437 creator A5029291993 @default.
- W4229013437 creator A5034965330 @default.
- W4229013437 creator A5040866854 @default.
- W4229013437 creator A5055700829 @default.
- W4229013437 creator A5060433417 @default.
- W4229013437 creator A5060870307 @default.
- W4229013437 creator A5064304750 @default.
- W4229013437 creator A5064560593 @default.
- W4229013437 creator A5066184259 @default.
- W4229013437 creator A5066984844 @default.
- W4229013437 creator A5067235835 @default.
- W4229013437 creator A5086861344 @default.
- W4229013437 creator A5091326218 @default.
- W4229013437 date "2022-08-31" @default.
- W4229013437 modified "2023-10-18" @default.
- W4229013437 title "A prospective case-control validation of procalcitonin as a biomarker diagnosing pacemaker and implantable cardioverter-defibrillator pocket infection" @default.
- W4229013437 doi "https://doi.org/10.33963/kp.a2022.0124" @default.
- W4229013437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35521718" @default.
- W4229013437 hasPublicationYear "2022" @default.
- W4229013437 type Work @default.
- W4229013437 citedByCount "0" @default.
- W4229013437 crossrefType "journal-article" @default.
- W4229013437 hasAuthorship W4229013437A5002116007 @default.
- W4229013437 hasAuthorship W4229013437A5012539245 @default.
- W4229013437 hasAuthorship W4229013437A5029291993 @default.
- W4229013437 hasAuthorship W4229013437A5034965330 @default.
- W4229013437 hasAuthorship W4229013437A5040866854 @default.
- W4229013437 hasAuthorship W4229013437A5055700829 @default.
- W4229013437 hasAuthorship W4229013437A5060433417 @default.
- W4229013437 hasAuthorship W4229013437A5060870307 @default.
- W4229013437 hasAuthorship W4229013437A5064304750 @default.
- W4229013437 hasAuthorship W4229013437A5064560593 @default.
- W4229013437 hasAuthorship W4229013437A5066184259 @default.
- W4229013437 hasAuthorship W4229013437A5066984844 @default.
- W4229013437 hasAuthorship W4229013437A5067235835 @default.
- W4229013437 hasAuthorship W4229013437A5086861344 @default.
- W4229013437 hasAuthorship W4229013437A5091326218 @default.
- W4229013437 hasBestOaLocation W42290134371 @default.
- W4229013437 hasConcept C10936531 @default.
- W4229013437 hasConcept C126322002 @default.
- W4229013437 hasConcept C185592680 @default.
- W4229013437 hasConcept C188816634 @default.
- W4229013437 hasConcept C2777093960 @default.
- W4229013437 hasConcept C2778384902 @default.
- W4229013437 hasConcept C2781197716 @default.
- W4229013437 hasConcept C44249647 @default.
- W4229013437 hasConcept C55493867 @default.
- W4229013437 hasConcept C58471807 @default.
- W4229013437 hasConcept C71924100 @default.
- W4229013437 hasConcept C76318530 @default.
- W4229013437 hasConcept C90924648 @default.
- W4229013437 hasConceptScore W4229013437C10936531 @default.
- W4229013437 hasConceptScore W4229013437C126322002 @default.
- W4229013437 hasConceptScore W4229013437C185592680 @default.
- W4229013437 hasConceptScore W4229013437C188816634 @default.
- W4229013437 hasConceptScore W4229013437C2777093960 @default.
- W4229013437 hasConceptScore W4229013437C2778384902 @default.
- W4229013437 hasConceptScore W4229013437C2781197716 @default.
- W4229013437 hasConceptScore W4229013437C44249647 @default.
- W4229013437 hasConceptScore W4229013437C55493867 @default.
- W4229013437 hasConceptScore W4229013437C58471807 @default.
- W4229013437 hasConceptScore W4229013437C71924100 @default.
- W4229013437 hasConceptScore W4229013437C76318530 @default.
- W4229013437 hasConceptScore W4229013437C90924648 @default.
- W4229013437 hasIssue "7-8" @default.
- W4229013437 hasLocation W42290134371 @default.
- W4229013437 hasLocation W42290134372 @default.
- W4229013437 hasOpenAccess W4229013437 @default.
- W4229013437 hasPrimaryLocation W42290134371 @default.
- W4229013437 hasRelatedWork W2055268934 @default.
- W4229013437 hasRelatedWork W2548120891 @default.
- W4229013437 hasRelatedWork W2903046167 @default.
- W4229013437 hasRelatedWork W2912194905 @default.
- W4229013437 hasRelatedWork W2971661229 @default.
- W4229013437 hasRelatedWork W2987377968 @default.
- W4229013437 hasRelatedWork W3031138809 @default.
- W4229013437 hasRelatedWork W3031194664 @default.
- W4229013437 hasRelatedWork W3171529692 @default.
- W4229013437 hasRelatedWork W3204585972 @default.
- W4229013437 hasVolume "80" @default.
- W4229013437 isParatext "false" @default.
- W4229013437 isRetracted "false" @default.
- W4229013437 workType "article" @default.