FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229013457> ?p ?o ?g. }

• W4229013457 endingPage "27" @default.
• W4229013457 startingPage "1" @default.
• W4229013457 abstract "Chronic sinusitis (CRS) was a chronic inflammation that originated in the nasal mucosa and affected the health of most people around the world. Chronic rhinosinusitis with nasal polyps (CRSwNP) was one kind of chronic sinusitis. Emerging research had suggested that long noncoding RNAs (lncRNAs) played vital parts in inflammatories and inflammation development.We acquired GEO data to analyze the differential expression between the miRNA, immune genes, TF, and lncRNA data in CRSWNP and the corresponding control tissues. Bioinformatic analysis by coexpression of endogenous RNA network and competitive way enrichment, analysis, and forecasting functions of these noncoding RNA. The different pathway expressions in CRSwNP patients were confirmed using GSVA to analyze the differentially expressed immune genes and TF data sets in CRSwNP patients. The differential immune gene and transcription factor data set in CRSwNP perform functional notes and protein-protein interaction (PPI) network structure. We predicted the potential genes and RNAs related to CRSWNP by constructing a ceRNA network. In addition, we also used 19 hub immune genes to predict the potential drugs of CRSWNP. lncRNA biomarkers in CRSwNP were identified by lncRNAs LASSO regression. The CIBERSORT algorithm was used to contrast the divergence in immune infiltrations between CRSwNP and usual inferior turbinate organizations in 22 immunocyte subgroups.We identified a total of 48 miRNAs, 304 lncRNAs, 92 TFs, and 525 immune genes as CRSwNP-specific RNAs. GO and KEGG pathways both analyzed differentially expressed immune genes and transcription factor data sets. We predicted the potential genes GNG7, TUSC8, LINC01198, and has-miR-6776-5p by constructing ceRNA and PPI networks. At the same time, we found that the above genes were involved in two important pathways: chemokine signal path and PI3K/AKT signal path. In addition, we predicted 5 small molecule drugs to treat CRSwNP by analyzing 19 central immune genes, namely, danazol, ikarugamycin, semustine, cefamandole, and molindone. Finally, we identified 5 biomarkers in CRSwNP, namely, LINC01198, LINC01094, LINC01798, LINC01829, and LINC01320.We had identified CRSwNP-related miRNAs, lncRNAs, TFs, and immune genes, which may be making use of latent therapeutic target for CRSwNP. At the same time, we identified 5 lncRNA biomarkers in CRSwNP. The results of this study showed that LINC01198 promoted the progression of CRSwNPs through spongy miR-6776-5p. Our studies provide a new way for further analyses of the pathogenesis of CRSwNP." @default.
• W4229013457 created "2022-05-08" @default.
• W4229013457 creator A5018650811 @default.
• W4229013457 creator A5020931258 @default.
• W4229013457 creator A5045093595 @default.
• W4229013457 creator A5071458554 @default.
• W4229013457 date "2022-05-06" @default.
• W4229013457 modified "2023-10-05" @default.
• W4229013457 title "Identification of lncRNA Biomarkers and LINC01198 Promotes Progression of Chronic Rhinosinusitis with Nasal Polyps through Sponge miR-6776-5p" @default.
• W4229013457 cites W1225221011 @default.
• W4229013457 cites W1611642663 @default.
• W4229013457 cites W1885435857 @default.
• W4229013457 cites W1972989638 @default.
• W4229013457 cites W2009893780 @default.
• W4229013457 cites W2023509990 @default.
• W4229013457 cites W2036380708 @default.
• W4229013457 cites W2044984501 @default.
• W4229013457 cites W2046387002 @default.
• W4229013457 cites W2046772525 @default.
• W4229013457 cites W2053159571 @default.
• W4229013457 cites W2054418937 @default.
• W4229013457 cites W2074849962 @default.
• W4229013457 cites W2105088246 @default.
• W4229013457 cites W2105347414 @default.
• W4229013457 cites W2130687298 @default.
• W4229013457 cites W2150296976 @default.
• W4229013457 cites W2157102252 @default.
• W4229013457 cites W2159482845 @default.
• W4229013457 cites W2300353401 @default.
• W4229013457 cites W2395672509 @default.
• W4229013457 cites W2471128678 @default.
• W4229013457 cites W2473768116 @default.
• W4229013457 cites W2604808360 @default.
• W4229013457 cites W2731708623 @default.
• W4229013457 cites W2751796012 @default.
• W4229013457 cites W2752636837 @default.
• W4229013457 cites W2784570320 @default.
• W4229013457 cites W2789595878 @default.
• W4229013457 cites W2789696794 @default.
• W4229013457 cites W2790455265 @default.
• W4229013457 cites W2802201055 @default.
• W4229013457 cites W2810758772 @default.
• W4229013457 cites W2937230843 @default.
• W4229013457 cites W2956356077 @default.
• W4229013457 cites W2963842611 @default.
• W4229013457 cites W2982711111 @default.
• W4229013457 cites W2993259418 @default.
• W4229013457 cites W2996529081 @default.
• W4229013457 cites W3001807704 @default.
• W4229013457 cites W3005998177 @default.
• W4229013457 cites W3009076370 @default.
• W4229013457 cites W3014182945 @default.
• W4229013457 cites W3014824237 @default.
• W4229013457 cites W3015291505 @default.
• W4229013457 cites W3022564264 @default.
• W4229013457 cites W3030610246 @default.
• W4229013457 cites W3038134106 @default.
• W4229013457 cites W3081756168 @default.
• W4229013457 cites W3084167067 @default.
• W4229013457 cites W3094468607 @default.
• W4229013457 cites W3109545780 @default.
• W4229013457 cites W3111457134 @default.
• W4229013457 cites W4247544731 @default.
• W4229013457 cites W4294216483 @default.
• W4229013457 doi "https://doi.org/10.1155/2022/9469207" @default.
• W4229013457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35572732" @default.
• W4229013457 hasPublicationYear "2022" @default.
• W4229013457 type Work @default.
• W4229013457 citedByCount "2" @default.
• W4229013457 countsByYear W42290134572023 @default.
• W4229013457 crossrefType "journal-article" @default.
• W4229013457 hasAuthorship W4229013457A5018650811 @default.
• W4229013457 hasAuthorship W4229013457A5020931258 @default.
• W4229013457 hasAuthorship W4229013457A5045093595 @default.
• W4229013457 hasAuthorship W4229013457A5071458554 @default.
• W4229013457 hasBestOaLocation W42290134571 @default.
• W4229013457 hasConcept C104317684 @default.
• W4229013457 hasConcept C145059251 @default.
• W4229013457 hasConcept C150194340 @default.
• W4229013457 hasConcept C152724338 @default.
• W4229013457 hasConcept C162317418 @default.
• W4229013457 hasConcept C203014093 @default.
• W4229013457 hasConcept C2781390199 @default.
• W4229013457 hasConcept C54355233 @default.
• W4229013457 hasConcept C60365752 @default.
• W4229013457 hasConcept C60644358 @default.
• W4229013457 hasConcept C62203573 @default.
• W4229013457 hasConcept C67705224 @default.
• W4229013457 hasConcept C70721500 @default.
• W4229013457 hasConcept C86339819 @default.
• W4229013457 hasConcept C86803240 @default.
• W4229013457 hasConcept C8891405 @default.
• W4229013457 hasConceptScore W4229013457C104317684 @default.
• W4229013457 hasConceptScore W4229013457C145059251 @default.
• W4229013457 hasConceptScore W4229013457C150194340 @default.
• W4229013457 hasConceptScore W4229013457C152724338 @default.
• W4229013457 hasConceptScore W4229013457C162317418 @default.
• W4229013457 hasConceptScore W4229013457C203014093 @default.

• next