Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229013530> ?p ?o ?g. }
- W4229013530 endingPage "911" @default.
- W4229013530 startingPage "911" @default.
- W4229013530 abstract "The critical factors for regulating cancer metabolism are oxidative stress and phosphoinositide-3-kinase/AKT serine-threonine kinase/mechanistic target of the rapamycin kinase (PI3K/AKT/mTOR). However, the metabolic impacts of oxidative stress and PI3K/AKT/mTOR on individual mechanisms such as glycolysis (Warburg effect), pentose phosphate pathway (PPP), fatty acid synthesis, tricarboxylic acid cycle (TCA) cycle, glutaminolysis, and oxidative phosphorylation (OXPHOS) are complicated. Therefore, this review summarizes the individual and interacting functions of oxidative stress and PI3K/AKT/mTOR on metabolism. Moreover, natural products providing oxidative stress and PI3K/AKT/mTOR modulating effects have anticancer potential. Using the example of brown algae-derived fucoidan, the roles of oxidative stress and PI3K/AKT/mTOR were summarized, although their potential functions within diverse metabolisms were rarely investigated. We propose a potential application that fucoidan may regulate oxidative stress and PI3K/AKT/mTOR signaling to modulate their associated metabolic regulations. This review sheds light on understanding the impacts of oxidative stress and PI3K/AKT/mTOR on metabolism and the future direction of metabolism-based cancer therapy of fucoidan." @default.
- W4229013530 created "2022-05-08" @default.
- W4229013530 creator A5003330387 @default.
- W4229013530 creator A5006129657 @default.
- W4229013530 creator A5036682215 @default.
- W4229013530 creator A5040790736 @default.
- W4229013530 creator A5074665298 @default.
- W4229013530 creator A5084088122 @default.
- W4229013530 creator A5089081230 @default.
- W4229013530 date "2022-05-06" @default.
- W4229013530 modified "2023-10-14" @default.
- W4229013530 title "Impacts of Oxidative Stress and PI3K/AKT/mTOR on Metabolism and the Future Direction of Investigating Fucoidan-Modulated Metabolism" @default.
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