FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229014145> ?p ?o ?g. }

• W4229014145 endingPage "165" @default.
• W4229014145 startingPage "158" @default.
• W4229014145 abstract "Although the use of BCR-ABL1 tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia is known to cause vascular adverse events (VAEs), the frequency of VAEs during dasatinib administration is not high, and the same holds for atherosclerosis-related VAEs. However, its effect on atherosclerosis remains controversial. In this study, our primary objective was to investigate how dasatinib affects atherosclerosis. Ldlr-/-/Apobec1-/- mice, which are highly prone to develop atherosclerosis, were administered dasatinib. After 16 weeks, we evaluated their atherosclerotic lesions. We used bone-marrow-derived macrophages to investigate the uptake of oxidized low-density lipoprotein (LDL) complexed with DiI dye (DiI-oxLDL). RNA sequencing and quantitative reverse transcription polymerase chain reaction (RT-qPCR) were performed to explore the potential effects of dasatinib on cholesterol metabolism. Dasatinib administration significantly reduced atherosclerotic lesions (P < 0.001 and P = 0.013) and DiI-oxLDL uptake (P < 0.001) unlike other TKIs. RNA sequencing and RT-qPCR suggested that Sort1, which encodes sortilin, a known regulator of LDL uptake, and Cd36 were potential targets of dasatinib. In conclusion, dasatinib induced elevated LDL-C levels, but oxLDL uptake in macrophages were suppressed, resulting in reducing atherosclerotic lesions. These results further our understanding of the differences in VAEs between dasatinib and other TKIs." @default.
• W4229014145 created "2022-05-08" @default.
• W4229014145 creator A5005966763 @default.
• W4229014145 creator A5008217392 @default.
• W4229014145 creator A5016748939 @default.
• W4229014145 creator A5077886356 @default.
• W4229014145 creator A5088202260 @default.
• W4229014145 creator A5088804804 @default.
• W4229014145 date "2022-07-01" @default.
• W4229014145 modified "2023-09-25" @default.
• W4229014145 title "Dasatinib suppresses atherosclerotic lesions by suppressing cholesterol uptake in a mouse model of hypercholesterolemia" @default.
• W4229014145 cites W1966985605 @default.
• W4229014145 cites W1982335809 @default.
• W4229014145 cites W2011186694 @default.
• W4229014145 cites W2039791966 @default.
• W4229014145 cites W2083153805 @default.
• W4229014145 cites W2095703660 @default.
• W4229014145 cites W2099540110 @default.
• W4229014145 cites W2115017173 @default.
• W4229014145 cites W2145835848 @default.
• W4229014145 cites W2147109509 @default.
• W4229014145 cites W2152435464 @default.
• W4229014145 cites W2244640457 @default.
• W4229014145 cites W2260921597 @default.
• W4229014145 cites W2336950376 @default.
• W4229014145 cites W2397234997 @default.
• W4229014145 cites W2428296383 @default.
• W4229014145 cites W2473480037 @default.
• W4229014145 cites W2610996294 @default.
• W4229014145 cites W2613857725 @default.
• W4229014145 cites W2740029254 @default.
• W4229014145 cites W2783688887 @default.
• W4229014145 cites W2802271217 @default.
• W4229014145 cites W2809972432 @default.
• W4229014145 cites W2891752553 @default.
• W4229014145 cites W2911580027 @default.
• W4229014145 cites W2912858991 @default.
• W4229014145 cites W2914897630 @default.
• W4229014145 cites W2922003298 @default.
• W4229014145 cites W2966332880 @default.
• W4229014145 cites W3024807331 @default.
• W4229014145 cites W3025268971 @default.
• W4229014145 doi "https://doi.org/10.1016/j.jphs.2022.04.009" @default.
• W4229014145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35641028" @default.
• W4229014145 hasPublicationYear "2022" @default.
• W4229014145 type Work @default.
• W4229014145 citedByCount "2" @default.
• W4229014145 countsByYear W42290141452023 @default.
• W4229014145 crossrefType "journal-article" @default.
• W4229014145 hasAuthorship W4229014145A5005966763 @default.
• W4229014145 hasAuthorship W4229014145A5008217392 @default.
• W4229014145 hasAuthorship W4229014145A5016748939 @default.
• W4229014145 hasAuthorship W4229014145A5077886356 @default.
• W4229014145 hasAuthorship W4229014145A5088202260 @default.
• W4229014145 hasAuthorship W4229014145A5088804804 @default.
• W4229014145 hasBestOaLocation W42290141451 @default.
• W4229014145 hasConcept C121608353 @default.
• W4229014145 hasConcept C126322002 @default.
• W4229014145 hasConcept C170493617 @default.
• W4229014145 hasConcept C2777583451 @default.
• W4229014145 hasConcept C2778163477 @default.
• W4229014145 hasConcept C2778729363 @default.
• W4229014145 hasConcept C2778820342 @default.
• W4229014145 hasConcept C2779536868 @default.
• W4229014145 hasConcept C2780007613 @default.
• W4229014145 hasConcept C2780072125 @default.
• W4229014145 hasConcept C42362537 @default.
• W4229014145 hasConcept C502942594 @default.
• W4229014145 hasConcept C71924100 @default.
• W4229014145 hasConcept C98274493 @default.
• W4229014145 hasConceptScore W4229014145C121608353 @default.
• W4229014145 hasConceptScore W4229014145C126322002 @default.
• W4229014145 hasConceptScore W4229014145C170493617 @default.
• W4229014145 hasConceptScore W4229014145C2777583451 @default.
• W4229014145 hasConceptScore W4229014145C2778163477 @default.
• W4229014145 hasConceptScore W4229014145C2778729363 @default.
• W4229014145 hasConceptScore W4229014145C2778820342 @default.
• W4229014145 hasConceptScore W4229014145C2779536868 @default.
• W4229014145 hasConceptScore W4229014145C2780007613 @default.
• W4229014145 hasConceptScore W4229014145C2780072125 @default.
• W4229014145 hasConceptScore W4229014145C42362537 @default.
• W4229014145 hasConceptScore W4229014145C502942594 @default.
• W4229014145 hasConceptScore W4229014145C71924100 @default.
• W4229014145 hasConceptScore W4229014145C98274493 @default.
• W4229014145 hasFunder F4320334764 @default.
• W4229014145 hasFunder F4320334934 @default.
• W4229014145 hasIssue "3" @default.
• W4229014145 hasLocation W42290141451 @default.
• W4229014145 hasLocation W42290141452 @default.
• W4229014145 hasOpenAccess W4229014145 @default.
• W4229014145 hasPrimaryLocation W42290141451 @default.
• W4229014145 hasRelatedWork W2017171402 @default.
• W4229014145 hasRelatedWork W2139973222 @default.
• W4229014145 hasRelatedWork W2163329109 @default.
• W4229014145 hasRelatedWork W2169861151 @default.
• W4229014145 hasRelatedWork W2184534421 @default.
• W4229014145 hasRelatedWork W2184746615 @default.
• W4229014145 hasRelatedWork W2266796555 @default.

• next