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• W4229014721 abstract "Historically, mainly by the work of Robert Berne, extracellular adenosine was the first purine compound recognized as an important signaling molecule linking energy metabolism to function by acting on membrane bound receptors. Geoffrey Burnstock by his vision and endurance pioneered the idea that cells release ATP that also acts as an extracellular signaling molecule under many physiological and pathophysiological circumstances. Only later, it was appreciated that extracellular ATP and adenosine are metabolically linked by the activity of several ectoenzymes which critically determine the concentrations of these purines at their respective receptors. In this brief review, I will report some personal recollections on Geoffrey Burnstock and his impressive personality. In addition, I will give a brief overview on our present knowledge of extracellular purine metabolism and its control and will address some still open issues." @default.
• W4229014721 created "2022-05-08" @default.
• W4229014721 creator A5057582462 @default.
• W4229014721 date "2022-05-06" @default.
• W4229014721 modified "2023-09-25" @default.
• W4229014721 title "Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock" @default.
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• W4229014721 doi "https://doi.org/10.1007/s11302-022-09862-6" @default.
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