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• W4229014734 abstract "P-glycoprotein (Pgp), an ATP binding cassette (ABC) transporter, is an ATP-dependent efflux pump responsible for cancer multidrug resistance. As part of efforts to identify human Pgp (hPgp) inhibitors, we prepared a series of novel triazole-conjugated dihydropyrimidinones using a synthetic approach that is well suited for obtaining compound libraries. Several of these dihydropyrimidinone derivatives modulate human P-glycoprotein (hPgp) activity with low micromolar EC50 values. Molecular docking studies suggest that these compounds bind to the M-site of the transporter." @default.
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• W4229014734 date "2022-05-02" @default.
• W4229014734 modified "2023-10-18" @default.
• W4229014734 title "Novel Dihydropyrimidinone Derivatives as Potential P-Glycoprotein Modulators" @default.
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• W4229014734 doi "https://doi.org/10.1021/acsomega.1c05839" @default.
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