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• W4229016161 abstract "Abstract Background B1 cells are self-renewing innate-like B lymphocytes that provide the first line of defense against pathogens. B1 cells primarily reside in the peritoneal cavity and are known to originate from various fetal tissues, yet their developmental pathways and the mechanisms underlying maintenance of B1 cells throughout adulthood remain unclear. Results We performed high-throughput single-cell analysis of the transcriptomes and B-cell receptor repertoires of peritoneal B cells of neonates, young adults, and elderly mice. Gene expression analysis of 31,718 peritoneal B cells showed that the neonate peritoneal cavity contained many B1 progenitors, and neonate B cell specific clustering revealed two trajectories of peritoneal B1 cell development, including pre-BCR dependent and pre-BCR independent pathways. We also detected profound age-related changes in B1 cell transcriptomes: clear difference in senescence genetic program was evident in differentially aged B1 cells, and we found an example that a B1 subset only present in the oldest mice was marked by expression of the fatty-acid receptor CD36. We also performed antibody gene sequencing of 15,967 peritoneal B cells from the three age groups and discovered that B1 cell aging was associated with clonal expansion and two B1 cell clones expanded in the aged mice had the same CDR-H3 sequence (AGDYDGYWYFDV) as a pathogenically linked cell type from a recent study of an atherosclerosis mouse model. Conclusions Beyond offering an unprecedent data resource to explore the cell-to-cell variation in B cells, our study has revealed that B1 precursor subsets are present in the neonate peritoneal cavity and dissected the developmental pathway of the precursor cells. Besides, this study has found the expression of CD36 on the B1 cells in the aged mice. And the single-cell B-cell receptor sequencing reveals B1 cell aging is associated with clonal expansion." @default.
• W4229016161 created "2022-05-08" @default.
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• W4229016161 date "2022-05-07" @default.
• W4229016161 modified "2023-09-30" @default.
• W4229016161 title "Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire" @default.
• W4229016161 cites W1487897082 @default.
• W4229016161 cites W1519617347 @default.
• W4229016161 cites W1533296902 @default.
• W4229016161 cites W1900474817 @default.
• W4229016161 cites W1956586550 @default.
• W4229016161 cites W1964812677 @default.
• W4229016161 cites W1968373260 @default.
• W4229016161 cites W1974951139 @default.
• W4229016161 cites W1975905715 @default.
• W4229016161 cites W1977099733 @default.
• W4229016161 cites W1980509634 @default.
• W4229016161 cites W1982094117 @default.
• W4229016161 cites W1983284948 @default.
• W4229016161 cites W1987529064 @default.
• W4229016161 cites W1988056929 @default.
• W4229016161 cites W1989277387 @default.
• W4229016161 cites W1989978175 @default.
• W4229016161 cites W1996418577 @default.
• W4229016161 cites W2004914260 @default.
• W4229016161 cites W2006111721 @default.
• W4229016161 cites W2008418299 @default.
• W4229016161 cites W2016486423 @default.
• W4229016161 cites W2018265741 @default.
• W4229016161 cites W2019389649 @default.
• W4229016161 cites W2023502808 @default.
• W4229016161 cites W2027226325 @default.
• W4229016161 cites W2031026925 @default.
• W4229016161 cites W2040576499 @default.
• W4229016161 cites W2050623157 @default.
• W4229016161 cites W2057294431 @default.
• W4229016161 cites W2060676171 @default.
• W4229016161 cites W2066502291 @default.
• W4229016161 cites W2070615015 @default.
• W4229016161 cites W2071207271 @default.
• W4229016161 cites W2072149435 @default.
• W4229016161 cites W2078356972 @default.
• W4229016161 cites W2080075942 @default.
• W4229016161 cites W2080558054 @default.
• W4229016161 cites W2083875480 @default.
• W4229016161 cites W2084825289 @default.
• W4229016161 cites W2097449625 @default.
• W4229016161 cites W2098027759 @default.
• W4229016161 cites W2099635702 @default.
• W4229016161 cites W2099972447 @default.
• W4229016161 cites W2103316970 @default.
• W4229016161 cites W2106020004 @default.
• W4229016161 cites W2106896872 @default.
• W4229016161 cites W2108569073 @default.
• W4229016161 cites W2109595158 @default.
• W4229016161 cites W2115826572 @default.
• W4229016161 cites W2116370657 @default.
• W4229016161 cites W2117455815 @default.
• W4229016161 cites W2118107917 @default.
• W4229016161 cites W2121059155 @default.
• W4229016161 cites W2122743195 @default.
• W4229016161 cites W2131261387 @default.
• W4229016161 cites W2132122568 @default.
• W4229016161 cites W2134283161 @default.
• W4229016161 cites W2135001195 @default.
• W4229016161 cites W2137266284 @default.
• W4229016161 cites W2138597400 @default.
• W4229016161 cites W2144479616 @default.
• W4229016161 cites W2149578241 @default.
• W4229016161 cites W2152212771 @default.
• W4229016161 cites W2153245546 @default.
• W4229016161 cites W2162701426 @default.
• W4229016161 cites W2169868745 @default.
• W4229016161 cites W2190545194 @default.
• W4229016161 cites W2261724133 @default.
• W4229016161 cites W2296577807 @default.
• W4229016161 cites W2298969345 @default.
• W4229016161 cites W2335855130 @default.
• W4229016161 cites W2509957998 @default.
• W4229016161 cites W2510869140 @default.
• W4229016161 cites W2517782886 @default.
• W4229016161 cites W2521223951 @default.
• W4229016161 cites W2558370188 @default.
• W4229016161 cites W2592449894 @default.
• W4229016161 cites W2760863738 @default.
• W4229016161 cites W2786854070 @default.
• W4229016161 cites W2787534140 @default.

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