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- W4229016786 abstract "Ectopic lymphoid structures (ELS) can develop in rheumatoid arthritis (RA) synovial tissue, but the precise pathways of B cell activation and selection are not well understood. Here, we identify a synovial B cell population characterized by co-expression of a family of orphan nuclear receptors (NR4A1-3), which is highly enriched in RA synovial tissue. A transcriptomic profile of NR4A synovial B cells significantly overlaps with germinal center light zone B cells and an accrual of somatic hypermutation that correlates with loss of naive B cell state. NR4A B cells co-express lymphotoxins α and β and IL-6, supporting functions in ELS promotion. Expanded and shared clones between synovial NR4A B cells and plasma cells and the rapid upregulation with BCR stimulation point to in situ differentiation. Together, we identify a dynamic progression of B cell activation in RA synovial ELS, with NR4A transcription factors having an important role in local adaptive immune responses." @default.
- W4229016786 created "2022-05-08" @default.
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- W4229016786 date "2022-05-01" @default.
- W4229016786 modified "2023-10-11" @default.
- W4229016786 title "Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression" @default.
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- W4229016786 cites W1765179944 @default.
- W4229016786 cites W1780852323 @default.
- W4229016786 cites W1835395435 @default.
- W4229016786 cites W1852406183 @default.
- W4229016786 cites W1922855985 @default.
- W4229016786 cites W1969218538 @default.
- W4229016786 cites W1974718865 @default.
- W4229016786 cites W1976236239 @default.
- W4229016786 cites W1990251286 @default.
- W4229016786 cites W1990948095 @default.
- W4229016786 cites W1998612840 @default.
- W4229016786 cites W2008116475 @default.
- W4229016786 cites W2013762850 @default.
- W4229016786 cites W2016175731 @default.
- W4229016786 cites W2022039920 @default.
- W4229016786 cites W2034586064 @default.
- W4229016786 cites W2046421048 @default.
- W4229016786 cites W2066214482 @default.
- W4229016786 cites W2071074768 @default.
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- W4229016786 cites W2099868898 @default.
- W4229016786 cites W2113987403 @default.
- W4229016786 cites W2132407668 @default.
- W4229016786 cites W2157620455 @default.
- W4229016786 cites W2158637536 @default.
- W4229016786 cites W2161725688 @default.
- W4229016786 cites W2166588660 @default.
- W4229016786 cites W2195959595 @default.
- W4229016786 cites W2403038751 @default.
- W4229016786 cites W2574629025 @default.
- W4229016786 cites W26089772 @default.
- W4229016786 cites W2610107585 @default.
- W4229016786 cites W2755000263 @default.
- W4229016786 cites W2760458695 @default.
- W4229016786 cites W2777889365 @default.
- W4229016786 cites W2794480084 @default.
- W4229016786 cites W2801474028 @default.
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- W4229016786 cites W2808965711 @default.
- W4229016786 cites W2811196739 @default.
- W4229016786 cites W2872432516 @default.
- W4229016786 cites W2887034336 @default.
- W4229016786 cites W2897114391 @default.
- W4229016786 cites W2902652201 @default.
- W4229016786 cites W2907514116 @default.
- W4229016786 cites W2916738215 @default.
- W4229016786 cites W2917547201 @default.
- W4229016786 cites W2920823803 @default.
- W4229016786 cites W2937406017 @default.
- W4229016786 cites W2949243209 @default.
- W4229016786 cites W2949631571 @default.
- W4229016786 cites W2951506174 @default.
- W4229016786 cites W2968405386 @default.
- W4229016786 cites W2970073611 @default.
- W4229016786 cites W2970472573 @default.
- W4229016786 cites W3005462348 @default.
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- W4229016786 cites W3043627823 @default.
- W4229016786 cites W3082070654 @default.
- W4229016786 cites W3097118140 @default.
- W4229016786 cites W3106098975 @default.
- W4229016786 cites W3127539648 @default.
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- W4229016786 doi "https://doi.org/10.1016/j.celrep.2022.110766" @default.
- W4229016786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35508128" @default.
- W4229016786 hasPublicationYear "2022" @default.
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