Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229020254> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4229020254 endingPage "F8" @default.
- W4229020254 startingPage "F1" @default.
- W4229020254 abstract "In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it has been established as the predominant sperm oocyte-activating factor. PLCZ1 cRNA expression or direct protein microinjection into mammalian oocytes triggers calcium (Ca 2+ ) oscillations indistinguishable from those observed at fertilization. The imperative role of PLCZ1 in oocyte activation is revealed by the vast number of human mutations throughout the PLCZ1 gene that have been identified and directly linked with certain forms of male infertility due to oocyte activation deficiency. PLCZ1 is the smallest PLC in size, comprising four N-terminal EF-hand domains, followed by X and Y catalytic domains, which are separated by the XY-linker, and ending with a C-terminal C2 domain. The EF hands are responsible for the high Ca 2+ sensitivity of PLCZ1. The X and Y catalytic domains are responsible for the catalysis of the phosphatidylinositol-4,5-bisphosphate [PI(4,5)P 2 ] substrate to produce the Ca 2+ -mobilising messenger, inositol 1,4,5-trisphosphate (IP 3 ), while the XY-linker plays multiple roles in the unique mode of PLCZ1 action. Finally, the C2 domain has been proposed to facilitate the anchoring of PLCZ1 to intracellular vesicles through its direct interactions with specific phosphoinositides. This review discusses recent advances in the structure and function relationship of PLCZ1 and the potential binding partners of this important sperm-specific protein in the sperm and oocyte. The unravelling of all the remaining hidden secrets of sperm PLCZ1 should help us to understand the precise mechanism of fertilization, as well as enabling the diagnosis and treatment of currently unknown forms of PLCZ1 -linked human infertility." @default.
- W4229020254 created "2022-05-08" @default.
- W4229020254 creator A5007494898 @default.
- W4229020254 creator A5008993235 @default.
- W4229020254 creator A5016435169 @default.
- W4229020254 creator A5073107235 @default.
- W4229020254 date "2022-07-01" @default.
- W4229020254 modified "2023-10-12" @default.
- W4229020254 title "SPERM FACTORS AND EGG ACTIVATION: The structure and function relationship of sperm PLCZ1" @default.
- W4229020254 doi "https://doi.org/10.1530/rep-21-0477" @default.
- W4229020254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35521907" @default.
- W4229020254 hasPublicationYear "2022" @default.
- W4229020254 type Work @default.
- W4229020254 citedByCount "7" @default.
- W4229020254 countsByYear W42290202542022 @default.
- W4229020254 countsByYear W42290202542023 @default.
- W4229020254 crossrefType "journal-article" @default.
- W4229020254 hasAuthorship W4229020254A5007494898 @default.
- W4229020254 hasAuthorship W4229020254A5008993235 @default.
- W4229020254 hasAuthorship W4229020254A5016435169 @default.
- W4229020254 hasAuthorship W4229020254A5073107235 @default.
- W4229020254 hasBestOaLocation W42290202541 @default.
- W4229020254 hasConcept C179265757 @default.
- W4229020254 hasConcept C185592680 @default.
- W4229020254 hasConcept C196843134 @default.
- W4229020254 hasConcept C2776690073 @default.
- W4229020254 hasConcept C2778597717 @default.
- W4229020254 hasConcept C2781087480 @default.
- W4229020254 hasConcept C54355233 @default.
- W4229020254 hasConcept C62478195 @default.
- W4229020254 hasConcept C62525196 @default.
- W4229020254 hasConcept C86803240 @default.
- W4229020254 hasConcept C88972607 @default.
- W4229020254 hasConcept C95444343 @default.
- W4229020254 hasConceptScore W4229020254C179265757 @default.
- W4229020254 hasConceptScore W4229020254C185592680 @default.
- W4229020254 hasConceptScore W4229020254C196843134 @default.
- W4229020254 hasConceptScore W4229020254C2776690073 @default.
- W4229020254 hasConceptScore W4229020254C2778597717 @default.
- W4229020254 hasConceptScore W4229020254C2781087480 @default.
- W4229020254 hasConceptScore W4229020254C54355233 @default.
- W4229020254 hasConceptScore W4229020254C62478195 @default.
- W4229020254 hasConceptScore W4229020254C62525196 @default.
- W4229020254 hasConceptScore W4229020254C86803240 @default.
- W4229020254 hasConceptScore W4229020254C88972607 @default.
- W4229020254 hasConceptScore W4229020254C95444343 @default.
- W4229020254 hasIssue "1" @default.
- W4229020254 hasLocation W42290202541 @default.
- W4229020254 hasLocation W42290202542 @default.
- W4229020254 hasLocation W42290202543 @default.
- W4229020254 hasOpenAccess W4229020254 @default.
- W4229020254 hasPrimaryLocation W42290202541 @default.
- W4229020254 hasRelatedWork W1550298527 @default.
- W4229020254 hasRelatedWork W1967876375 @default.
- W4229020254 hasRelatedWork W2265404956 @default.
- W4229020254 hasRelatedWork W2409720367 @default.
- W4229020254 hasRelatedWork W2767514012 @default.
- W4229020254 hasRelatedWork W2803069890 @default.
- W4229020254 hasRelatedWork W2955039104 @default.
- W4229020254 hasRelatedWork W4200574740 @default.
- W4229020254 hasRelatedWork W4308650448 @default.
- W4229020254 hasRelatedWork W2166577723 @default.
- W4229020254 hasVolume "164" @default.
- W4229020254 isParatext "false" @default.
- W4229020254 isRetracted "false" @default.
- W4229020254 workType "article" @default.