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- W4229021844 endingPage "108799" @default.
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- W4229021844 abstract "The type III interferon family (IFN-III), including IFN-λ3 [interleukin (IL)-28B], has antiviral, anti-tumor, and immunomodulatory activities. Although the IL-28B anti-tumor effect has been extensively explored, its underlying mechanism remains unclear. Here, we explored IL-28B effects on colon cancer. Our results show that IL-28B significantly inhibits colon cancer progression in a mouse MC38 tumor cell colonization model and colitis-associated colorectal tumor model. Interestingly, IL-28B does not directly promote apoptosis or inhibit MC38 tumor cell proliferation in vitro. Rather, IL-28B treatment has indirect anti-tumor activity by downregulating tumor-associated macrophages. Furthermore, IL-28B inhibits M2 macrophage polarization in vitro, while also halting M2 macrophage differentiation predominantly via inhibition of the signal transducer and activator of transcription (STAT)3 and c-Jun N-terminal kinase (JNK) signaling pathways. Our findings revealed that IL-28B inhibits M2 macrophages in the tumor microenvironment to delay colon cancer progression. These findings provide novel evidence of IL-28B anti-tumor and immunomodulatory activities." @default.
- W4229021844 created "2022-05-08" @default.
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- W4229021844 date "2022-08-01" @default.
- W4229021844 modified "2023-09-24" @default.
- W4229021844 title "IL-28B reprograms tumor-associated macrophages to promote anti-tumor effects in colon cancer" @default.
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- W4229021844 doi "https://doi.org/10.1016/j.intimp.2022.108799" @default.
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