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- W4229026054 abstract "Abstract Co-culturing the bacterium Streptomyces rapamycinicus and the ascomycete Aspergillus nidulans has previously been shown to trigger the production of orsellinic acid (ORS) and its derivates in the fungal cells. Based on these studies it was assumed that direct physical contact is a prerequisite for the metabolic reaction that involves a fungal amino acid starvation response and activating chromatin modifications at the biosynthetic gene cluster (BGC). Here we show that not physical contact, but a guanidine containing macrolide, named polaramycin B, triggers the response. The substance is produced constitutively by the bacterium and provokes the production of ORS above a certain concentration. In addition, several other secondary metabolites were induced by polaramycin B. Our genome-wide transcriptome analysis showed that polaramycin B treatment causes down-regulation of fungal genes necessary for membrane stability, general metabolism and growth. A compensatory genetic response can be observed in the fungus that included up-regulation of BGCs and genes necessary for ribosome biogenesis, translation and membrane stability. Our work discovered a novel chemical communication, in which the antifungal bacterial metabolite polaramycin B leads to the production of antibacterial defence chemicals and to the up-regulation of genes necessary to compensate for the cellular damage caused by polaramycin B." @default.
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- W4229026054 date "2022-05-04" @default.
- W4229026054 modified "2023-09-26" @default.
- W4229026054 title "Polaramycin B, and not physical interaction, is the signal that rewires fungal metabolism in the Streptomyces – Aspergillus interaction" @default.
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- W4229026054 doi "https://doi.org/10.1101/2022.05.04.490618" @default.
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