FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229029595> ?p ?o ?g. }

• W4229029595 abstract "Within the pulmonary arterial tree, the NOTCH3 pathway is crucial in controlling vascular smooth muscle cell proliferation and maintaining smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension (PAH) is a fatal disease without cure, characterized by elevated pulmonary vascular resistance due to vascular smooth muscle cell proliferation in precapillary arteries, perivascular inflammation, and asymmetric neointimal hyperplasia. Here, we show that human PAH is characterized by overexpression of the NOTCH ligand JAGGED-1 (JAG-1) in small pulmonary artery smooth muscle cells and that JAG-1 selectively controls NOTCH3 signaling and cellular proliferation in an autocrine fashion. In contrast, the NOTCH ligand DELTA-LIKE 4 is minimally expressed in small pulmonary artery smooth muscle cells from individuals with PAH, inhibits NOTCH3 cleavage and signaling, and retards vascular smooth muscle cell proliferation. A new monoclonal antibody for the treatment of PAH, which blocks JAG-1 cis- and trans-induced cleavage of the NOTCH3 receptor in the pulmonary vasculature, was developed. Inhibition of JAG-1-induced NOTCH3 signaling in the lung reverses clinical and pathologic pulmonary hypertension in two rodent models of disease, without toxic side effects associated with nonspecific NOTCH inhibitors. Our data suggest opposing roles of NOTCH ligands in the pulmonary vasculature in pulmonary hypertension. We propose that selectively targeting JAG-1 activation of NOTCH3 may be an effective, safe strategy to treat PAH." @default.
• W4229029595 created "2022-05-08" @default.
• W4229029595 creator A5007868182 @default.
• W4229029595 creator A5008213446 @default.
• W4229029595 creator A5042351221 @default.
• W4229029595 creator A5042484004 @default.
• W4229029595 creator A5057518084 @default.
• W4229029595 creator A5064441182 @default.
• W4229029595 creator A5068880098 @default.
• W4229029595 creator A5070187864 @default.
• W4229029595 creator A5088249880 @default.
• W4229029595 date "2022-05-04" @default.
• W4229029595 modified "2023-10-01" @default.
• W4229029595 title "JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension" @default.
• W4229029595 cites W1443506455 @default.
• W4229029595 cites W1579318277 @default.
• W4229029595 cites W1876419424 @default.
• W4229029595 cites W1888188715 @default.
• W4229029595 cites W1902299005 @default.
• W4229029595 cites W2005679640 @default.
• W4229029595 cites W2015200964 @default.
• W4229029595 cites W2019769268 @default.
• W4229029595 cites W2040238490 @default.
• W4229029595 cites W2042082068 @default.
• W4229029595 cites W2055468924 @default.
• W4229029595 cites W2075002475 @default.
• W4229029595 cites W2076754613 @default.
• W4229029595 cites W2083425643 @default.
• W4229029595 cites W2084835859 @default.
• W4229029595 cites W2090218100 @default.
• W4229029595 cites W2097705657 @default.
• W4229029595 cites W2103336748 @default.
• W4229029595 cites W2109541355 @default.
• W4229029595 cites W2109805795 @default.
• W4229029595 cites W2110287546 @default.
• W4229029595 cites W2112629089 @default.
• W4229029595 cites W2118444666 @default.
• W4229029595 cites W2128213692 @default.
• W4229029595 cites W2131232783 @default.
• W4229029595 cites W2132001965 @default.
• W4229029595 cites W2147435977 @default.
• W4229029595 cites W2160127145 @default.
• W4229029595 cites W2167099419 @default.
• W4229029595 cites W2284711770 @default.
• W4229029595 cites W2604796353 @default.
• W4229029595 cites W2740908790 @default.
• W4229029595 cites W2758464302 @default.
• W4229029595 cites W2771001400 @default.
• W4229029595 cites W2798985900 @default.
• W4229029595 cites W2883812201 @default.
• W4229029595 cites W2891328244 @default.
• W4229029595 cites W2979181902 @default.
• W4229029595 cites W2980912163 @default.
• W4229029595 cites W2995516686 @default.
• W4229029595 cites W3005169221 @default.
• W4229029595 cites W3046402837 @default.
• W4229029595 cites W3049454825 @default.
• W4229029595 cites W3127970989 @default.
• W4229029595 cites W3150453735 @default.
• W4229029595 cites W3195895030 @default.
• W4229029595 cites W3210755460 @default.
• W4229029595 doi "https://doi.org/10.1126/scitranslmed.abl5471" @default.
• W4229029595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35507674" @default.
• W4229029595 hasPublicationYear "2022" @default.
• W4229029595 type Work @default.
• W4229029595 citedByCount "16" @default.
• W4229029595 countsByYear W42290295952022 @default.
• W4229029595 countsByYear W42290295952023 @default.
• W4229029595 crossrefType "journal-article" @default.
• W4229029595 hasAuthorship W4229029595A5007868182 @default.
• W4229029595 hasAuthorship W4229029595A5008213446 @default.
• W4229029595 hasAuthorship W4229029595A5042351221 @default.
• W4229029595 hasAuthorship W4229029595A5042484004 @default.
• W4229029595 hasAuthorship W4229029595A5057518084 @default.
• W4229029595 hasAuthorship W4229029595A5064441182 @default.
• W4229029595 hasAuthorship W4229029595A5068880098 @default.
• W4229029595 hasAuthorship W4229029595A5070187864 @default.
• W4229029595 hasAuthorship W4229029595A5088249880 @default.
• W4229029595 hasConcept C126322002 @default.
• W4229029595 hasConcept C128240485 @default.
• W4229029595 hasConcept C142724271 @default.
• W4229029595 hasConcept C161879069 @default.
• W4229029595 hasConcept C170493617 @default.
• W4229029595 hasConcept C2777562237 @default.
• W4229029595 hasConcept C2777714996 @default.
• W4229029595 hasConcept C2779395532 @default.
• W4229029595 hasConcept C2779751240 @default.
• W4229029595 hasConcept C2780930700 @default.
• W4229029595 hasConcept C2780940725 @default.
• W4229029595 hasConcept C2992686903 @default.
• W4229029595 hasConcept C502942594 @default.
• W4229029595 hasConcept C71924100 @default.
• W4229029595 hasConceptScore W4229029595C126322002 @default.
• W4229029595 hasConceptScore W4229029595C128240485 @default.
• W4229029595 hasConceptScore W4229029595C142724271 @default.
• W4229029595 hasConceptScore W4229029595C161879069 @default.
• W4229029595 hasConceptScore W4229029595C170493617 @default.
• W4229029595 hasConceptScore W4229029595C2777562237 @default.
• W4229029595 hasConceptScore W4229029595C2777714996 @default.
• W4229029595 hasConceptScore W4229029595C2779395532 @default.

• next