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- W4229030016 endingPage "110778" @default.
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- W4229030016 abstract "Antibody-mediated immunity is initiated by B cell differentiation into multiple cell subsets, including plasmablast, memory, and germinal center (GC) cells. B cell differentiation trajectories are determined by transcription factors, yet very few mechanisms that specifically determine early B cell fates have been described. Here, we report a post-transcriptional mechanism that suppresses the plasmablast genetic program and promotes GC B cell fate commitment. Single-cell RNA-sequencing analysis reveals that antigen-specific B cell precursors at the pre-GC stage upregulate YTHDF2, which enhances the decay of methylated transcripts. Ythdf2-deficient B cells exhibit intact proliferation and activation, whereas differentiation into GC B cells is blocked. Mechanistically, B cells require YTHDF2 to attenuate the plasmablast genetic program during GC seeding, and transcripts of key plasmablast-regulating genes are methylated and bound by YTHDF2. Collectively, this study reveals how post-transcriptional suppression of gene expression directs appropriate B cell fate commitment during initiation of the adaptive immune response." @default.
- W4229030016 created "2022-05-08" @default.
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- W4229030016 creator A5062661857 @default.
- W4229030016 date "2022-05-01" @default.
- W4229030016 modified "2023-09-26" @default.
- W4229030016 title "YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation" @default.
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- W4229030016 cites W1964113455 @default.
- W4229030016 cites W1988622164 @default.
- W4229030016 cites W1988796527 @default.
- W4229030016 cites W1991497659 @default.
- W4229030016 cites W2016175731 @default.
- W4229030016 cites W2016450373 @default.
- W4229030016 cites W2018427441 @default.
- W4229030016 cites W2021341670 @default.
- W4229030016 cites W2045067923 @default.
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- W4229030016 cites W2056703680 @default.
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- W4229030016 cites W2069590838 @default.
- W4229030016 cites W2070012169 @default.
- W4229030016 cites W2070050178 @default.
- W4229030016 cites W2071010503 @default.
- W4229030016 cites W2071959000 @default.
- W4229030016 cites W2072863253 @default.
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- W4229030016 cites W2789822082 @default.
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- W4229030016 cites W2794480084 @default.
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- W4229030016 doi "https://doi.org/10.1016/j.celrep.2022.110778" @default.
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