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- W4229030156 abstract "We report expression and purification of a FLT3 protein with ITD mutation (FLT3-ITD) with a steady tyrosine kinase activity using a silkworm-baculovirus system, and its application as a fast screening system of tyrosine kinase inhibitors. The FLT3-ITD protein was expressed in Bombyx mori L. pupae infected by gene-modified nucleopolyhedrovirus, and was purified as an active state. We performed an inhibition assay using 17 kinase inhibitors, and succeeded in screening two inhibitors for FLT3-ITD. The result has paved the way for screening FLT3-ITD inhibitors in a fast and easy manner, and also for structural studies." @default.
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- W4229030156 date "2022-05-05" @default.
- W4229030156 modified "2023-09-24" @default.
- W4229030156 title "Fast in-vitro screening of FLT3-ITD inhibitors using silkworm-baculovirus protein expression system" @default.
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- W4229030156 doi "https://doi.org/10.1371/journal.pone.0261699" @default.
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