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• W4229034637 abstract "Preclinical data suggest a protective role of statins in patients (pts) with breast cancer. Clinical data are controversial with limited data on the benefit for pts with HER2-positive early breast cancer (HER2+ EBC). We investigated the association of statin use with survival outcomes in pts with HER2+ EBC enrolled in APHINITY (BIG 4-11/NCT01358877). APHINITY is a prospective, randomized, double-blind, phase III trial testing the addition of pertuzumab to trastuzumab and chemotherapy in pts with HER2+ EBC. All pts evaluated in APHINITY were included in the present analysis (N=4804). Pts who received statins at baseline, or started statins within one year from randomization were considered as statin users. Pts’ characteristics were compared according to statin use by chi-square test. Survival analysis for invasive-disease-free survival (IDFS), distant relapse-free interval (DRFI), and overall survival (OS) were performed using the Kaplan Meier method and log-rank test. A multivariate analysis using a Cox proportional hazard model was used to generate hazard ratios (HR), adjusting for tumor size, nodal status, hormone receptor status, age, menopausal status, body mass index (BMI) ≥ 30 kg/m2, treatment arm and statin use. Median follow-up was 6 years. Statin users (N=423) were more frequently ≥65 years old, postmenopausal, obese (BMI ≥ 30 kg/m2) and were treated more often with breast conserving surgery compared to non-statin users (N=4381) (all p<.001). In multivariate analysis, no significant impact of statin use on any of the survival outcomes was observed (IDFS, HR 1.17, 95% confidence interval [CI] 0.86-1.59; DRFI, HR 1.22, 95% CI 0.83-1.79; OS, HR 1.18, 95% CI 0.80-1.72). No significant interaction between statin use, obesity, treatment arm, hormone receptor status and survival could be detected (p>.05). In this analysis, statin use was not associated with improved survival outcomes in the relatively young EBC population enrolled in APHINITY. We acknowledge the retrospective and exploratory nature of the present analysis. Further research should explore the potential clinical benefit of statins in a higher risk (e.g. older age) EBC population." @default.
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• W4229034637 date "2022-05-01" @default.
• W4229034637 modified "2023-10-01" @default.
• W4229034637 title "69P Impact of statin use on survival outcomes of patients with HER2-positive early breast cancer in the APHINITY trial" @default.
• W4229034637 doi "https://doi.org/10.1016/j.annonc.2022.03.085" @default.
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