FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229034681> ?p ?o ?g. }

• W4229034681 abstract "Abstract BACKGROUND AND AIMS Blood volume (BV) is an important clinical parameter and is usually expressed relative to body weight (BW), but is inappropriate with elevated fat mass. We hypothesized that established differences in BV and hemoglobin mass (Hbmass) between male and female would vanish if expressed per lean body mass (LBM) instead of BW. We furthermore aimed to establish reference values for BV, plasma volume, red blood cell volume and Hbmass in women and men for clinical use. METHOD Blood volumes (carbon monoxide rebreathing) and body composition (DXA scan) were determined in 225 female and 280 healthy men (18–93 years, BMI range: 16.4–40.6). RESULTS As expected, female absolute BV was 1570 mL [CI 95% (1429.66–1709.87)]; P-value ≤.001) less than in male, and also when expressed per BW female had lower values than male (Figure 1A) [CI 95% (8.06–12.02); P-value ≤.001]. However, when expressed to LBM, females had 6.3 mL higher value than males [CI 95% (−8.80 to −3.86); P-value ≤ .001] (Figure 2A). In a similar manner, absolute Hbmass was 303 g greater in male [CI 95% = (283.99–322.09); P-value ≤ .001] and also greater when expressed pr BW [CI 95% (2.37–2.88); P-value ≤ .001] (Figure 1D). However, when normalized to LBM, differences were greatly diminished −0.84 [CI 95% (0.53–1.15); P-value ≤ .001] (Figure 2B). Per year of older age, a man gains 0.14 [0.06–0.22] mL blood/LBM (P = .0012) and a woman gains 0.13 [0.04–0.22] mL (P = .0032), but the increase in blood volume is not different between men and women (no interaction effect, P = .92). Similar observations as for BV and Hbmass were also made for red blood cell volume and plasma volume (See Figs. 1 and 2). CONCLUSION The principal finding is that when BV and Hbmass are expressed relative to LBM, the known differences in intravascular volumes and Hbmass between male and female largely disappear. Furthermore, the relation between LBM and intracvascular volumes and Hbmass is preserved with advancing age. Taken together, LBM is a very strong predictor for intravascular volumes and Hbmass in healthy humans and could be considered a valuable clinical matrix in medical care aiming to normalize intravascular volumes in patients such as chronic kidney failure and heart failure." @default.
• W4229034681 created "2022-05-08" @default.
• W4229034681 creator A5009949348 @default.
• W4229034681 creator A5066850019 @default.
• W4229034681 date "2022-05-01" @default.
• W4229034681 modified "2023-09-28" @default.
• W4229034681 title "MO524: Gender Differences in Intravascular Volumes Vanish if Expressed per Lean Body Mass" @default.
• W4229034681 doi "https://doi.org/10.1093/ndt/gfac072.006" @default.
• W4229034681 hasPublicationYear "2022" @default.
• W4229034681 type Work @default.
• W4229034681 citedByCount "0" @default.
• W4229034681 crossrefType "journal-article" @default.
• W4229034681 hasAuthorship W4229034681A5009949348 @default.
• W4229034681 hasAuthorship W4229034681A5066850019 @default.
• W4229034681 hasConcept C120863210 @default.
• W4229034681 hasConcept C126322002 @default.
• W4229034681 hasConcept C134018914 @default.
• W4229034681 hasConcept C140793950 @default.
• W4229034681 hasConcept C147583825 @default.
• W4229034681 hasConcept C2778917026 @default.
• W4229034681 hasConcept C2780221984 @default.
• W4229034681 hasConcept C2989005 @default.
• W4229034681 hasConcept C2993503589 @default.
• W4229034681 hasConcept C37557685 @default.
• W4229034681 hasConcept C71924100 @default.
• W4229034681 hasConcept C86803240 @default.
• W4229034681 hasConceptScore W4229034681C120863210 @default.
• W4229034681 hasConceptScore W4229034681C126322002 @default.
• W4229034681 hasConceptScore W4229034681C134018914 @default.
• W4229034681 hasConceptScore W4229034681C140793950 @default.
• W4229034681 hasConceptScore W4229034681C147583825 @default.
• W4229034681 hasConceptScore W4229034681C2778917026 @default.
• W4229034681 hasConceptScore W4229034681C2780221984 @default.
• W4229034681 hasConceptScore W4229034681C2989005 @default.
• W4229034681 hasConceptScore W4229034681C2993503589 @default.
• W4229034681 hasConceptScore W4229034681C37557685 @default.
• W4229034681 hasConceptScore W4229034681C71924100 @default.
• W4229034681 hasConceptScore W4229034681C86803240 @default.
• W4229034681 hasIssue "Supplement_3" @default.
• W4229034681 hasLocation W42290346811 @default.
• W4229034681 hasOpenAccess W4229034681 @default.
• W4229034681 hasPrimaryLocation W42290346811 @default.
• W4229034681 hasRelatedWork W1512226674 @default.
• W4229034681 hasRelatedWork W2001893919 @default.
• W4229034681 hasRelatedWork W2013644072 @default.
• W4229034681 hasRelatedWork W2014830377 @default.
• W4229034681 hasRelatedWork W2027757116 @default.
• W4229034681 hasRelatedWork W2074119199 @default.
• W4229034681 hasRelatedWork W2083434745 @default.
• W4229034681 hasRelatedWork W2112902524 @default.
• W4229034681 hasRelatedWork W2120147367 @default.
• W4229034681 hasRelatedWork W2600404518 @default.
• W4229034681 hasVolume "37" @default.
• W4229034681 isParatext "false" @default.
• W4229034681 isRetracted "false" @default.
• W4229034681 workType "article" @default.