Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229035861> ?p ?o ?g. }
- W4229035861 endingPage "580" @default.
- W4229035861 startingPage "573" @default.
- W4229035861 abstract "Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) have been conducted predominantly in individuals of European descent, the limited transferability of PRS reduces their clinical value in non-European populations, and may exacerbate healthcare disparities. Recent efforts to level ancestry imbalance in genomic research have expanded the scale of non-European GWAS, although most remain underpowered. Here, we present a new PRS construction method, PRS-CSx, which improves cross-population polygenic prediction by integrating GWAS summary statistics from multiple populations. PRS-CSx couples genetic effects across populations via a shared continuous shrinkage (CS) prior, enabling more accurate effect size estimation by sharing information between summary statistics and leveraging linkage disequilibrium diversity across discovery samples, while inheriting computational efficiency and robustness from PRS-CS. We show that PRS-CSx outperforms alternative methods across traits with a wide range of genetic architectures, cross-population genetic overlaps and discovery GWAS sample sizes in simulations, and improves the prediction of quantitative traits and schizophrenia risk in non-European populations." @default.
- W4229035861 created "2022-05-08" @default.
- W4229035861 creator A5000252117 @default.
- W4229035861 creator A5001561307 @default.
- W4229035861 creator A5004089539 @default.
- W4229035861 creator A5005156882 @default.
- W4229035861 creator A5005786868 @default.
- W4229035861 creator A5006058010 @default.
- W4229035861 creator A5006217384 @default.
- W4229035861 creator A5006974520 @default.
- W4229035861 creator A5007532331 @default.
- W4229035861 creator A5009784167 @default.
- W4229035861 creator A5013177258 @default.
- W4229035861 creator A5013193278 @default.
- W4229035861 creator A5013257622 @default.
- W4229035861 creator A5014856167 @default.
- W4229035861 creator A5015137967 @default.
- W4229035861 creator A5020912488 @default.
- W4229035861 creator A5021063513 @default.
- W4229035861 creator A5023417562 @default.
- W4229035861 creator A5024722983 @default.
- W4229035861 creator A5025730618 @default.
- W4229035861 creator A5026771827 @default.
- W4229035861 creator A5028999046 @default.
- W4229035861 creator A5030355219 @default.
- W4229035861 creator A5030829801 @default.
- W4229035861 creator A5031613969 @default.
- W4229035861 creator A5032091947 @default.
- W4229035861 creator A5032711494 @default.
- W4229035861 creator A5034723746 @default.
- W4229035861 creator A5037361623 @default.
- W4229035861 creator A5038645756 @default.
- W4229035861 creator A5039047791 @default.
- W4229035861 creator A5039633463 @default.
- W4229035861 creator A5041572476 @default.
- W4229035861 creator A5043632388 @default.
- W4229035861 creator A5044176155 @default.
- W4229035861 creator A5049514873 @default.
- W4229035861 creator A5052927105 @default.
- W4229035861 creator A5052986606 @default.
- W4229035861 creator A5054069029 @default.
- W4229035861 creator A5055040294 @default.
- W4229035861 creator A5055995520 @default.
- W4229035861 creator A5057142349 @default.
- W4229035861 creator A5061632695 @default.
- W4229035861 creator A5063587278 @default.
- W4229035861 creator A5065075154 @default.
- W4229035861 creator A5068377771 @default.
- W4229035861 creator A5069018183 @default.
- W4229035861 creator A5072253152 @default.
- W4229035861 creator A5072459674 @default.
- W4229035861 creator A5072555008 @default.
- W4229035861 creator A5075467680 @default.
- W4229035861 creator A5075662908 @default.
- W4229035861 creator A5076458955 @default.
- W4229035861 creator A5077028160 @default.
- W4229035861 creator A5077058528 @default.
- W4229035861 creator A5077112770 @default.
- W4229035861 creator A5079162930 @default.
- W4229035861 creator A5080153638 @default.
- W4229035861 creator A5081812746 @default.
- W4229035861 creator A5082124101 @default.
- W4229035861 creator A5082394856 @default.
- W4229035861 creator A5082871715 @default.
- W4229035861 creator A5087774736 @default.
- W4229035861 creator A5089075288 @default.
- W4229035861 date "2022-05-01" @default.
- W4229035861 modified "2023-10-16" @default.
- W4229035861 title "Improving polygenic prediction in ancestrally diverse populations" @default.
- W4229035861 cites W2082704080 @default.
- W4229035861 cites W2098597355 @default.
- W4229035861 cites W2099085143 @default.
- W4229035861 cites W2101357408 @default.
- W4229035861 cites W2102381029 @default.
- W4229035861 cites W2104549677 @default.
- W4229035861 cites W2128371599 @default.
- W4229035861 cites W2148534890 @default.
- W4229035861 cites W2153860431 @default.
- W4229035861 cites W2169795969 @default.
- W4229035861 cites W2280070832 @default.
- W4229035861 cites W2345958530 @default.
- W4229035861 cites W2438256301 @default.
- W4229035861 cites W2531587846 @default.
- W4229035861 cites W2598022332 @default.
- W4229035861 cites W2613151407 @default.
- W4229035861 cites W2741020202 @default.
- W4229035861 cites W2769205163 @default.
- W4229035861 cites W2789833091 @default.
- W4229035861 cites W2803332630 @default.
- W4229035861 cites W2886752110 @default.
- W4229035861 cites W2922534626 @default.
- W4229035861 cites W2932671560 @default.
- W4229035861 cites W2936480486 @default.
- W4229035861 cites W2949848466 @default.
- W4229035861 cites W2950135831 @default.
- W4229035861 cites W2951553270 @default.
- W4229035861 cites W2952013316 @default.
- W4229035861 cites W2952882474 @default.