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• W4229041146 endingPage "121544" @default.
• W4229041146 startingPage "121544" @default.
• W4229041146 abstract "Osteoarthritis (OA) is a progressive degenerative joint disease which results in chronic degeneration of articular cartilage and sclerosis of bone. While tendons and ligaments may heal to a limited extent, articular cartilage has poor intrinsic regenerative potential, and critical-sized bone defects and pathological fractures cannot regenerate spontaneously. OA represents a significant burden of disease globally, affecting 240 million people in the world. The objective of tissue engineering is to recapitulate the natural healing cascade and developmental process by transplanting stromal and progenitor cells which can act directly or indirectly. As the ultimate goal of regenerative medicine is to avoid in vitro expansion of cells and its associated complications, the adipose-derived stromal cell (ASC) is an attractive progenitor cell for tissue engineering for treatment of OA. While clinical studies are still in their infancy, ASCs together with novel scaffold materials represent promising treatment options for patients suffering from OA. How ASCs exert their regenerative potential is a topic of debate, whereby it may be a result of direct differentiation of ASCs into the desired regenerating tissue, and/or through paracrine activity. With the advancement of material science, it is increasingly possible to enhance engraftment of ASCs through the use of biomaterials or to direct progenitor cell fate by activating biophysical signals through designed material microstructures. There are currently over 180 completed or ongoing registered early stage clinical trials involving ASCs, with 17 completed studies reviewed herein detailing the use of ASCs in OA. In order for ASC therapy to become an off-the-shelf option for treating OA, several strategies are currently being explored such as ASC cryopreservation and use of allogeneic ASCs. Newer approaches, such as exosome therapy, allow for the use of acellular ASC-derived therapies and are also currently the focus of ongoing investigations." @default.
• W4229041146 created "2022-05-08" @default.
• W4229041146 creator A5014997170 @default.
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• W4229041146 creator A5045807903 @default.
• W4229041146 creator A5054403091 @default.
• W4229041146 creator A5073695878 @default.
• W4229041146 date "2022-07-01" @default.
• W4229041146 modified "2023-10-10" @default.
• W4229041146 title "Musculoskeletal tissue engineering: Adipose derived stromal cell implementation for the treatment of osteoarthritis" @default.
• W4229041146 cites W1527183685 @default.
• W4229041146 cites W1555066299 @default.
• W4229041146 cites W1606976518 @default.
• W4229041146 cites W1630170504 @default.
• W4229041146 cites W1650284538 @default.
• W4229041146 cites W1836448277 @default.
• W4229041146 cites W1917918369 @default.
• W4229041146 cites W1933045257 @default.
• W4229041146 cites W1967536512 @default.
• W4229041146 cites W1968628080 @default.
• W4229041146 cites W1972228155 @default.
• W4229041146 cites W1975139004 @default.
• W4229041146 cites W1978251816 @default.
• W4229041146 cites W1978405687 @default.
• W4229041146 cites W1984098071 @default.
• W4229041146 cites W1986147205 @default.
• W4229041146 cites W1992006010 @default.
• W4229041146 cites W2003509125 @default.
• W4229041146 cites W2005305730 @default.
• W4229041146 cites W2005323891 @default.
• W4229041146 cites W2005559480 @default.
• W4229041146 cites W2009936900 @default.
• W4229041146 cites W2017429680 @default.
• W4229041146 cites W2018398216 @default.
• W4229041146 cites W2021306520 @default.
• W4229041146 cites W2022007497 @default.
• W4229041146 cites W2024588402 @default.
• W4229041146 cites W2024793853 @default.
• W4229041146 cites W2025371271 @default.
• W4229041146 cites W2029627567 @default.
• W4229041146 cites W2032410497 @default.
• W4229041146 cites W2041302930 @default.
• W4229041146 cites W2044760997 @default.
• W4229041146 cites W2050600834 @default.
• W4229041146 cites W2052774003 @default.
• W4229041146 cites W2053233954 @default.
• W4229041146 cites W2055424631 @default.
• W4229041146 cites W2056579495 @default.
• W4229041146 cites W2057401167 @default.
• W4229041146 cites W2057575850 @default.
• W4229041146 cites W2060323157 @default.
• W4229041146 cites W2061035981 @default.
• W4229041146 cites W2061981400 @default.
• W4229041146 cites W2064632011 @default.
• W4229041146 cites W2065460430 @default.
• W4229041146 cites W2067255342 @default.
• W4229041146 cites W2070334783 @default.
• W4229041146 cites W2075670261 @default.
• W4229041146 cites W2075903041 @default.
• W4229041146 cites W2076792879 @default.
• W4229041146 cites W2078828283 @default.
• W4229041146 cites W2079691345 @default.
• W4229041146 cites W2084917141 @default.
• W4229041146 cites W2085554170 @default.
• W4229041146 cites W2089863521 @default.
• W4229041146 cites W2095944209 @default.
• W4229041146 cites W2096874334 @default.
• W4229041146 cites W2098082628 @default.
• W4229041146 cites W2102638899 @default.
• W4229041146 cites W2107503723 @default.
• W4229041146 cites W2109298880 @default.
• W4229041146 cites W2116500923 @default.
• W4229041146 cites W2116513474 @default.
• W4229041146 cites W2118788475 @default.
• W4229041146 cites W2121354606 @default.
• W4229041146 cites W2122822855 @default.
• W4229041146 cites W2134208433 @default.
• W4229041146 cites W2136853488 @default.
• W4229041146 cites W2138735409 @default.
• W4229041146 cites W2144825002 @default.
• W4229041146 cites W2145752025 @default.
• W4229041146 cites W2147032549 @default.
• W4229041146 cites W2154830836 @default.
• W4229041146 cites W2157023674 @default.
• W4229041146 cites W2160991148 @default.
• W4229041146 cites W2174154237 @default.
• W4229041146 cites W2231350081 @default.
• W4229041146 cites W2236433435 @default.
• W4229041146 cites W2267939095 @default.
• W4229041146 cites W2268140784 @default.
• W4229041146 cites W2268783183 @default.
• W4229041146 cites W2281127733 @default.
• W4229041146 cites W2286064488 @default.
• W4229041146 cites W2296072011 @default.
• W4229041146 cites W2298308095 @default.
• W4229041146 cites W2345867153 @default.
• W4229041146 cites W2396239855 @default.

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