FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229041695> ?p ?o ?g. }

• W4229041695 abstract "This study aimed to evaluate whether calcitriol supplementation enhances CD4+ T cell count and prognosis in patients with tuberculosis and low 25(OH)D levels.This randomized controlled clinical trial enrolled treatment-naïve patients with tuberculosis admitted to Zigong First People's Hospital (June 2016 to April 2017). The patients were grouped as the serum 25(OH)D ≥ 75 nmol/L (Normal-25(OH)D) and 25(OH)D < 75 nmol/L (Low-25(OH)D) groups. The Low-Vit-D group was randomized to the Low-25(OH)D and Low-25(OH)D-Calcitriol groups. All patients were treated with the 2HRZE/4HR regimen. The patients in the Low-25(OH)D-Calcitriol group received calcitriol 0.25 µg bid. The main endpoints were CD4+ T cell count during treatment, time to sputum culture conversion, time to 50% lesion absorption, and a 6-month cure rate.This study included 30 patients in each group. Baseline 25-(OH) D levels and CD4+ T cell counts were higher in the Normal-25(OH)D group than in the Low-25(OH)D and Low-25(OH)D-Calcitriol groups (25(OH)D: 79.3 ± 3.4 vs. 37.8 ± 13.4 vs. 11.9 nmol/L, P < 0.05; 671 ± 287 vs. 200 ± 110 vs. 194 ± 119 cell/µL, P < 0.05). 25-(OH) D levels and CD4+ T cell counts increased in the Low-25(OH)D-Calcitriol group during treatment to reach higher levels than in the Low-25(OH)D group at 1, 4, 8, and 24 weeks (all P < 0.05). Compared with the Low-25(OH)D group, the Low-25(OH)D-Calcitriol group showed shorter time to sputum culture conversion (3.2 ± 1.4 vs. 5.9 ± 2.5 days, P < 0.001) and time to 50% lesion absorption (7.4 ± 1.5 vs. 10.9 ± 4.0 days, P = 0.014) and similar to those in the Normal-25(OH)D group (3.1 ± 1.2 and 7.3 ± 1.5 days, respectively. The cure rate was 86.7% in the Low-25(OH)D group and 96.7% in the two other groups.Calcitriol supplementation can elevate CD4+ T cell levels, shorten the time to sputum culture conversion, and accelerate lesion absorption in patients with tuberculosis and 25(OH)D deficiency. Trial registration The study is registered at the Chinese Clinical Trial Registry (ChiCTR2000039832)." @default.
• W4229041695 created "2022-05-08" @default.
• W4229041695 creator A5000323703 @default.
• W4229041695 creator A5023022142 @default.
• W4229041695 creator A5090445585 @default.
• W4229041695 date "2022-05-05" @default.
• W4229041695 modified "2023-10-18" @default.
• W4229041695 title "Calcitriol supplementation accelerates the recovery of patients with tuberculosis who have vitamin D deficiency: a randomized, single-blind, controlled clinical trial" @default.
• W4229041695 cites W110517169 @default.
• W4229041695 cites W1752367926 @default.
• W4229041695 cites W185119688 @default.
• W4229041695 cites W1900794757 @default.
• W4229041695 cites W1994698540 @default.
• W4229041695 cites W2001079134 @default.
• W4229041695 cites W2006629043 @default.
• W4229041695 cites W2027237291 @default.
• W4229041695 cites W2030885164 @default.
• W4229041695 cites W2053066061 @default.
• W4229041695 cites W2058419095 @default.
• W4229041695 cites W2078484023 @default.
• W4229041695 cites W2084074381 @default.
• W4229041695 cites W2094080536 @default.
• W4229041695 cites W2102969898 @default.
• W4229041695 cites W2103024679 @default.
• W4229041695 cites W2104754533 @default.
• W4229041695 cites W2107443281 @default.
• W4229041695 cites W2116841061 @default.
• W4229041695 cites W2146523219 @default.
• W4229041695 cites W2153059487 @default.
• W4229041695 cites W2154401560 @default.
• W4229041695 cites W2157133006 @default.
• W4229041695 cites W2268006712 @default.
• W4229041695 cites W2398342076 @default.
• W4229041695 cites W2409328471 @default.
• W4229041695 cites W2556729395 @default.
• W4229041695 cites W2734785873 @default.
• W4229041695 cites W2771357711 @default.
• W4229041695 cites W2797467981 @default.
• W4229041695 cites W2811128385 @default.
• W4229041695 cites W2889361028 @default.
• W4229041695 cites W2891513962 @default.
• W4229041695 cites W2912546399 @default.
• W4229041695 cites W2913925559 @default.
• W4229041695 cites W2972899386 @default.
• W4229041695 cites W2979086839 @default.
• W4229041695 cites W2983401020 @default.
• W4229041695 cites W2995073818 @default.
• W4229041695 cites W2997212705 @default.
• W4229041695 cites W2999622127 @default.
• W4229041695 cites W3011848332 @default.
• W4229041695 cites W3014678914 @default.
• W4229041695 cites W3024191257 @default.
• W4229041695 cites W3040226284 @default.
• W4229041695 cites W3044520856 @default.
• W4229041695 cites W3086474119 @default.
• W4229041695 cites W4229626291 @default.
• W4229041695 cites W4248452774 @default.
• W4229041695 cites W583485048 @default.
• W4229041695 doi "https://doi.org/10.1186/s12879-022-07427-x" @default.
• W4229041695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35513795" @default.
• W4229041695 hasPublicationYear "2022" @default.
• W4229041695 type Work @default.
• W4229041695 citedByCount "1" @default.
• W4229041695 countsByYear W42290416952023 @default.
• W4229041695 crossrefType "journal-article" @default.
• W4229041695 hasAuthorship W4229041695A5000323703 @default.
• W4229041695 hasAuthorship W4229041695A5023022142 @default.
• W4229041695 hasAuthorship W4229041695A5090445585 @default.
• W4229041695 hasBestOaLocation W42290416951 @default.
• W4229041695 hasConcept C124490489 @default.
• W4229041695 hasConcept C126322002 @default.
• W4229041695 hasConcept C168563851 @default.
• W4229041695 hasConcept C2776079296 @default.
• W4229041695 hasConcept C2779740938 @default.
• W4229041695 hasConcept C2781413609 @default.
• W4229041695 hasConcept C71924100 @default.
• W4229041695 hasConcept C90924648 @default.
• W4229041695 hasConceptScore W4229041695C124490489 @default.
• W4229041695 hasConceptScore W4229041695C126322002 @default.
• W4229041695 hasConceptScore W4229041695C168563851 @default.
• W4229041695 hasConceptScore W4229041695C2776079296 @default.
• W4229041695 hasConceptScore W4229041695C2779740938 @default.
• W4229041695 hasConceptScore W4229041695C2781413609 @default.
• W4229041695 hasConceptScore W4229041695C71924100 @default.
• W4229041695 hasConceptScore W4229041695C90924648 @default.
• W4229041695 hasIssue "1" @default.
• W4229041695 hasLocation W42290416951 @default.
• W4229041695 hasLocation W42290416952 @default.
• W4229041695 hasLocation W42290416953 @default.
• W4229041695 hasOpenAccess W4229041695 @default.
• W4229041695 hasPrimaryLocation W42290416951 @default.
• W4229041695 hasRelatedWork W2017890428 @default.
• W4229041695 hasRelatedWork W2036053574 @default.
• W4229041695 hasRelatedWork W2062079718 @default.
• W4229041695 hasRelatedWork W2109226149 @default.
• W4229041695 hasRelatedWork W2209356321 @default.
• W4229041695 hasRelatedWork W23032388 @default.
• W4229041695 hasRelatedWork W2417545840 @default.
• W4229041695 hasRelatedWork W2966490370 @default.
• W4229041695 hasRelatedWork W3132300275 @default.

• next