Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229042555> ?p ?o ?g. }
- W4229042555 abstract "Abstract Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older patients, and the identification of potential therapeutic targets for AML is problematic. Autophagy is a lysosome-dependent catabolic pathway involved in the tumorigenesis and/or treatment of various cancers. Mounting evidence has suggested that autophagy plays a critical role in the initiation and progression of AML and anticancer responses. In this review, we describe recent updates on the multifaceted functions of autophagy linking to genetic alterations of AML. We also summarize the latest evidence for autophagy-related genes as potential prognostic predictors and drivers of AML tumorigenesis. We then discuss the crosstalk between autophagy and tumor cell metabolism into the impact on both AML progression and anti-leukemic treatment. Moreover, a series of autophagy regulators, i.e., the inhibitors and activators, are described as potential therapeutics for AML. Finally, we describe the translation of autophagy-modulating therapeutics into clinical practice. Autophagy in AML is a double-edged sword, necessitating a deeper understanding of how autophagy influences dual functions in AML tumorigenesis and anti-leukemic responses." @default.
- W4229042555 created "2022-05-08" @default.
- W4229042555 creator A5010991078 @default.
- W4229042555 creator A5049327895 @default.
- W4229042555 creator A5079059549 @default.
- W4229042555 creator A5088283936 @default.
- W4229042555 date "2022-05-07" @default.
- W4229042555 modified "2023-10-13" @default.
- W4229042555 title "The dual role of autophagy in acute myeloid leukemia" @default.
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