Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229042575> ?p ?o ?g. }
- W4229042575 endingPage "1579" @default.
- W4229042575 startingPage "1569" @default.
- W4229042575 abstract "Aerobic exercise prescription is often set at specific heart rate (HR) values. Previous studies demonstrated that during exercise carried out at a HR slightly above that corresponding to the gas exchange threshold (GET), work rate (WR) has to decrease in order to maintain HR constant. We hypothesized a greater WR decrease at a fixed HR after simulated microgravity/inactivity (bed rest, BR). Ten male volunteers (23 ± 5 yr) were tested before (PRE) and after (POST) a 10-day horizontal BR and performed on a cycle ergometer 1) incremental exercise; b) 15-min HRCLAMPED exercise, in which WR was continuously adjusted to maintain a constant HR, corresponding to that at 120% of GET determined in PRE; 3) two moderate-intensity constant WR (MOD) exercises. Breath-by-breath O2 uptake (V̇o2), HR, and other variables were determined. After BR, peak V̇o2 (V̇o2peak) and GET significantly decreased, by ∼10%. During HRCLAMPED (145 ± 11 beats·min-1), the decrease in WR needed to maintain a constant HR was greater in POST versus PRE (-39 ± 10% vs. -29 ± 14%, P < 0.01). In six subjects the decreased WR switched from the heavy- to the moderate-intensity domain. The decrease in WR during HRCLAMPED, in PRE versus POST, was significantly correlated with the V̇o2peak decrease (R2 = 0.52; P = 0.02). A greater amplitude of the slow component of the HR kinetics was observed during MOD following BR. Exercise at a fixed HR is not associated with a specific WR or WR domain; the problem, affecting exercise evaluation and prescription, is greater after BR. The WR decrease during HRCLAMPED is a biomarker of exercise intolerance after BR.NEW & NOTEWORTHY During a 15-min exercise carried out at a heart rate (HR) slightly above that corresponding to the gas exchange threshold, to keep HR constant work rate significantly decreased; the decrease was more pronounced after a 10-day horizontal bed rest. The work rate decrease at a fixed HR can be considered a systemic biomarker of exercise intolerance during microgravity/inactivity and could also be easily and reliably determined during spaceflights or in patients." @default.
- W4229042575 created "2022-05-08" @default.
- W4229042575 creator A5008302540 @default.
- W4229042575 creator A5018343644 @default.
- W4229042575 creator A5023465330 @default.
- W4229042575 creator A5026883632 @default.
- W4229042575 creator A5028423278 @default.
- W4229042575 creator A5033207879 @default.
- W4229042575 creator A5036710760 @default.
- W4229042575 creator A5040336531 @default.
- W4229042575 creator A5051448713 @default.
- W4229042575 creator A5064113871 @default.
- W4229042575 creator A5069472150 @default.
- W4229042575 creator A5078215355 @default.
- W4229042575 date "2022-06-01" @default.
- W4229042575 modified "2023-10-14" @default.
- W4229042575 title "Decrease in work rate in order to keep a constant heart rate: biomarker of exercise intolerance following a 10-day bed rest" @default.
- W4229042575 cites W1595719943 @default.
- W4229042575 cites W1899906888 @default.
- W4229042575 cites W1926015747 @default.
- W4229042575 cites W1956646296 @default.
- W4229042575 cites W1970085285 @default.
- W4229042575 cites W1972748825 @default.
- W4229042575 cites W1976543530 @default.
- W4229042575 cites W1978575836 @default.
- W4229042575 cites W1978795695 @default.
- W4229042575 cites W1984233725 @default.
- W4229042575 cites W1988061845 @default.
- W4229042575 cites W1999332100 @default.
- W4229042575 cites W2020002251 @default.
- W4229042575 cites W2037030586 @default.
- W4229042575 cites W2041950757 @default.
- W4229042575 cites W2063019054 @default.
- W4229042575 cites W2074989836 @default.
- W4229042575 cites W2075550904 @default.
- W4229042575 cites W2090296913 @default.
- W4229042575 cites W2093229999 @default.
- W4229042575 cites W2093358993 @default.
- W4229042575 cites W2093985390 @default.
- W4229042575 cites W2109335962 @default.
- W4229042575 cites W2113192551 @default.
- W4229042575 cites W2114512692 @default.
- W4229042575 cites W2145139856 @default.
- W4229042575 cites W2157729482 @default.
- W4229042575 cites W2176052317 @default.
- W4229042575 cites W2177308194 @default.
- W4229042575 cites W2178177034 @default.
- W4229042575 cites W2187042800 @default.
- W4229042575 cites W2326614593 @default.
- W4229042575 cites W2406024689 @default.
- W4229042575 cites W2487851432 @default.
- W4229042575 cites W2735256000 @default.
- W4229042575 cites W2789310266 @default.
- W4229042575 cites W2800253572 @default.
- W4229042575 cites W2908763664 @default.
- W4229042575 cites W2921674975 @default.
- W4229042575 cites W2971629420 @default.
- W4229042575 cites W3045134239 @default.
- W4229042575 cites W3094777799 @default.
- W4229042575 cites W3184771127 @default.
- W4229042575 cites W3198812321 @default.
- W4229042575 cites W4220848390 @default.
- W4229042575 cites W4292949922 @default.
- W4229042575 doi "https://doi.org/10.1152/japplphysiol.00052.2022" @default.
- W4229042575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35511721" @default.
- W4229042575 hasPublicationYear "2022" @default.
- W4229042575 type Work @default.
- W4229042575 citedByCount "0" @default.
- W4229042575 crossrefType "journal-article" @default.
- W4229042575 hasAuthorship W4229042575A5008302540 @default.
- W4229042575 hasAuthorship W4229042575A5018343644 @default.
- W4229042575 hasAuthorship W4229042575A5023465330 @default.
- W4229042575 hasAuthorship W4229042575A5026883632 @default.
- W4229042575 hasAuthorship W4229042575A5028423278 @default.
- W4229042575 hasAuthorship W4229042575A5033207879 @default.
- W4229042575 hasAuthorship W4229042575A5036710760 @default.
- W4229042575 hasAuthorship W4229042575A5040336531 @default.
- W4229042575 hasAuthorship W4229042575A5051448713 @default.
- W4229042575 hasAuthorship W4229042575A5064113871 @default.
- W4229042575 hasAuthorship W4229042575A5069472150 @default.
- W4229042575 hasAuthorship W4229042575A5078215355 @default.
- W4229042575 hasConcept C121332964 @default.
- W4229042575 hasConcept C126322002 @default.
- W4229042575 hasConcept C133165541 @default.
- W4229042575 hasConcept C134018914 @default.
- W4229042575 hasConcept C140793950 @default.
- W4229042575 hasConcept C164705383 @default.
- W4229042575 hasConcept C181588539 @default.
- W4229042575 hasConcept C185592680 @default.
- W4229042575 hasConcept C1862650 @default.
- W4229042575 hasConcept C2776811442 @default.
- W4229042575 hasConcept C2777953023 @default.
- W4229042575 hasConcept C2778856057 @default.
- W4229042575 hasConcept C2779673892 @default.
- W4229042575 hasConcept C2781094410 @default.
- W4229042575 hasConcept C2994262451 @default.
- W4229042575 hasConcept C5140985 @default.
- W4229042575 hasConcept C62520636 @default.