FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229042668> ?p ?o ?g. }

• W4229042668 abstract "Significance A target-agnostic approach that harnesses the human antitumor immune response to find potential anticancer lead antibodies and their targets was used to generate ATRC-101, an engineered version of a tumor-targeting antibody identified from a patient with non-small cell lung cancer experiencing an ongoing antitumor immune response. ATRC-101 is an antibody that targets an extracellular, tumor-specific ribonucleoprotein complex. Here, we describe the extracellular binding of this complex and antitumor activity of ATRC-101 in murine models. Preclinical data suggest a mechanism of action in which ATRC-101 activates myeloid cells of the innate immune system, leading to an adaptive immune response that yields its antitumor activity. These data have led to an ongoing phase 1 trial in patients with advanced solid tumors." @default.
• W4229042668 created "2022-05-08" @default.
• W4229042668 creator A5000080830 @default.
• W4229042668 creator A5000253491 @default.
• W4229042668 creator A5008190453 @default.
• W4229042668 creator A5010467338 @default.
• W4229042668 creator A5012772285 @default.
• W4229042668 creator A5014529623 @default.
• W4229042668 creator A5014721829 @default.
• W4229042668 creator A5016275445 @default.
• W4229042668 creator A5018003194 @default.
• W4229042668 creator A5021775232 @default.
• W4229042668 creator A5034158449 @default.
• W4229042668 creator A5036035716 @default.
• W4229042668 creator A5040035355 @default.
• W4229042668 creator A5040832373 @default.
• W4229042668 creator A5040924182 @default.
• W4229042668 creator A5044042087 @default.
• W4229042668 creator A5052628974 @default.
• W4229042668 creator A5055511953 @default.
• W4229042668 creator A5055661521 @default.
• W4229042668 creator A5058516905 @default.
• W4229042668 creator A5059183159 @default.
• W4229042668 creator A5061817015 @default.
• W4229042668 creator A5062680237 @default.
• W4229042668 creator A5064585233 @default.
• W4229042668 creator A5069014561 @default.
• W4229042668 creator A5072288339 @default.
• W4229042668 creator A5072350649 @default.
• W4229042668 creator A5073545313 @default.
• W4229042668 creator A5074817413 @default.
• W4229042668 creator A5075382144 @default.
• W4229042668 creator A5086313414 @default.
• W4229042668 creator A5089781611 @default.
• W4229042668 date "2022-05-04" @default.
• W4229042668 modified "2023-10-16" @default.
• W4229042668 title "Mobilization of innate and adaptive antitumor immune responses by the RNP-targeting antibody ATRC-101" @default.
• W4229042668 cites W1914776013 @default.
• W4229042668 cites W1970182669 @default.
• W4229042668 cites W1986178107 @default.
• W4229042668 cites W2007056945 @default.
• W4229042668 cites W2031661454 @default.
• W4229042668 cites W2058178349 @default.
• W4229042668 cites W2073115216 @default.
• W4229042668 cites W2140582776 @default.
• W4229042668 cites W2209284337 @default.
• W4229042668 cites W2517416985 @default.
• W4229042668 cites W2761980878 @default.
• W4229042668 cites W2765836977 @default.
• W4229042668 cites W2893742037 @default.
• W4229042668 cites W2898845456 @default.
• W4229042668 cites W2903686952 @default.
• W4229042668 cites W2913135237 @default.
• W4229042668 cites W2916569843 @default.
• W4229042668 cites W2922876350 @default.
• W4229042668 cites W2945590213 @default.
• W4229042668 cites W2981784931 @default.
• W4229042668 cites W3000522739 @default.
• W4229042668 cites W3006654174 @default.
• W4229042668 cites W3017272456 @default.
• W4229042668 cites W3036050630 @default.
• W4229042668 cites W3040716217 @default.
• W4229042668 cites W3080330000 @default.
• W4229042668 cites W3084097164 @default.
• W4229042668 cites W3162916603 @default.
• W4229042668 cites W3183508816 @default.
• W4229042668 doi "https://doi.org/10.1073/pnas.2123483119" @default.
• W4229042668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35507878" @default.
• W4229042668 hasPublicationYear "2022" @default.
• W4229042668 type Work @default.
• W4229042668 citedByCount "0" @default.
• W4229042668 crossrefType "journal-article" @default.
• W4229042668 hasAuthorship W4229042668A5000080830 @default.
• W4229042668 hasAuthorship W4229042668A5000253491 @default.
• W4229042668 hasAuthorship W4229042668A5008190453 @default.
• W4229042668 hasAuthorship W4229042668A5010467338 @default.
• W4229042668 hasAuthorship W4229042668A5012772285 @default.
• W4229042668 hasAuthorship W4229042668A5014529623 @default.
• W4229042668 hasAuthorship W4229042668A5014721829 @default.
• W4229042668 hasAuthorship W4229042668A5016275445 @default.
• W4229042668 hasAuthorship W4229042668A5018003194 @default.
• W4229042668 hasAuthorship W4229042668A5021775232 @default.
• W4229042668 hasAuthorship W4229042668A5034158449 @default.
• W4229042668 hasAuthorship W4229042668A5036035716 @default.
• W4229042668 hasAuthorship W4229042668A5040035355 @default.
• W4229042668 hasAuthorship W4229042668A5040832373 @default.
• W4229042668 hasAuthorship W4229042668A5040924182 @default.
• W4229042668 hasAuthorship W4229042668A5044042087 @default.
• W4229042668 hasAuthorship W4229042668A5052628974 @default.
• W4229042668 hasAuthorship W4229042668A5055511953 @default.
• W4229042668 hasAuthorship W4229042668A5055661521 @default.
• W4229042668 hasAuthorship W4229042668A5058516905 @default.
• W4229042668 hasAuthorship W4229042668A5059183159 @default.
• W4229042668 hasAuthorship W4229042668A5061817015 @default.
• W4229042668 hasAuthorship W4229042668A5062680237 @default.
• W4229042668 hasAuthorship W4229042668A5064585233 @default.
• W4229042668 hasAuthorship W4229042668A5069014561 @default.
• W4229042668 hasAuthorship W4229042668A5072288339 @default.
• W4229042668 hasAuthorship W4229042668A5072350649 @default.
• W4229042668 hasAuthorship W4229042668A5073545313 @default.

• next