Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229043487> ?p ?o ?g. }
- W4229043487 endingPage "106" @default.
- W4229043487 startingPage "91" @default.
- W4229043487 abstract "Tumors are usually refractory to anti-cancer therapeutics under hypoxic conditions. However, the underlying molecular mechanism remains to be elucidated. Our study intended to identify hypoxia inducible lncRNAs and their biological function in gastric cancer (GC). Differentially expressed lncRNAs were determined by microarray analysis between GC cells exposed to hypoxia (1% O2) and normoxia (21% O2) for 24 h. The expression level of CBSLR was manipulated in several GC cell lines to perform molecular and biological analyses both in vitro and in vivo. We identified a hypoxia-induced lncRNA-CBSLR that protected GC cells from ferroptosis, leading to chem-resistance. Mechanically, CBSLR interacted with YTHDF2 to form a CBSLR/YTHDF2/CBS signaling axis that decreased the stability of CBS mRNA by enhancing the binding of YTHDF2 with the m6A-modified coding sequence (CDS) of CBS mRNA. Furthermore, under decreased CBS levels, the methylation of the ACSL4 protein was reduced, leading to protein polyubiquitination and degradation of ACSL4. This, in turn, decreased the pro-ferroptosis phosphatidylethanolamine (PE) (18:0/20:4) and PE (18:0/22:4) content and contributed to ferroptosis resistance. Notably, CBSLR is upregulated, whereas CBS is downregulated in GC tissues compared to matched normal tissues; and GC patients with high CBSLR/low CBS levels have a worse clinical outcome and a poorer response to chemotherapy. Our study reveals a novel mechanism in how HIF1α/CBSLR modulates ferroptosis/chemoresistance in GC, illuminating potential therapeutic targets for refractory hypoxic tumors." @default.
- W4229043487 created "2022-05-08" @default.
- W4229043487 creator A5007923055 @default.
- W4229043487 creator A5023017424 @default.
- W4229043487 creator A5029377042 @default.
- W4229043487 creator A5030801732 @default.
- W4229043487 creator A5049252104 @default.
- W4229043487 creator A5072133977 @default.
- W4229043487 creator A5075447752 @default.
- W4229043487 creator A5080704061 @default.
- W4229043487 creator A5086664284 @default.
- W4229043487 creator A5087983244 @default.
- W4229043487 date "2022-03-01" @default.
- W4229043487 modified "2023-10-16" @default.
- W4229043487 title "Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer" @default.
- W4229043487 cites W1798710600 @default.
- W4229043487 cites W1973592190 @default.
- W4229043487 cites W1986035938 @default.
- W4229043487 cites W1987981719 @default.
- W4229043487 cites W2011131953 @default.
- W4229043487 cites W2027661066 @default.
- W4229043487 cites W2048678284 @default.
- W4229043487 cites W2057860618 @default.
- W4229043487 cites W2072506120 @default.
- W4229043487 cites W2096680263 @default.
- W4229043487 cites W2122358139 @default.
- W4229043487 cites W2158937157 @default.
- W4229043487 cites W2272984102 @default.
- W4229043487 cites W2306179365 @default.
- W4229043487 cites W2507685096 @default.
- W4229043487 cites W2549188196 @default.
- W4229043487 cites W2627007286 @default.
- W4229043487 cites W2670484694 @default.
- W4229043487 cites W2754689486 @default.
- W4229043487 cites W2810413223 @default.
- W4229043487 cites W2890397692 @default.
- W4229043487 cites W2891906735 @default.
- W4229043487 cites W2892980924 @default.
- W4229043487 cites W2908755714 @default.
- W4229043487 cites W2909955689 @default.
- W4229043487 cites W2912369228 @default.
- W4229043487 cites W2922969171 @default.
- W4229043487 cites W2964024721 @default.
- W4229043487 cites W2968612009 @default.
- W4229043487 cites W2984672214 @default.
- W4229043487 cites W2999574447 @default.
- W4229043487 cites W3000233190 @default.
- W4229043487 cites W3004744154 @default.
- W4229043487 cites W3006048658 @default.
- W4229043487 cites W3013936205 @default.
- W4229043487 cites W3082891477 @default.
- W4229043487 cites W3090693089 @default.
- W4229043487 cites W3101330565 @default.
- W4229043487 cites W3112895250 @default.
- W4229043487 cites W3115880421 @default.
- W4229043487 cites W3122102409 @default.
- W4229043487 cites W3123922203 @default.
- W4229043487 cites W3125100065 @default.
- W4229043487 cites W3127839532 @default.
- W4229043487 cites W3128646645 @default.
- W4229043487 cites W3134252533 @default.
- W4229043487 cites W4210990885 @default.
- W4229043487 doi "https://doi.org/10.1016/j.jare.2021.10.001" @default.
- W4229043487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35499052" @default.
- W4229043487 hasPublicationYear "2022" @default.
- W4229043487 type Work @default.
- W4229043487 citedByCount "47" @default.
- W4229043487 countsByYear W42290434872022 @default.
- W4229043487 countsByYear W42290434872023 @default.
- W4229043487 crossrefType "journal-article" @default.
- W4229043487 hasAuthorship W4229043487A5007923055 @default.
- W4229043487 hasAuthorship W4229043487A5023017424 @default.
- W4229043487 hasAuthorship W4229043487A5029377042 @default.
- W4229043487 hasAuthorship W4229043487A5030801732 @default.
- W4229043487 hasAuthorship W4229043487A5049252104 @default.
- W4229043487 hasAuthorship W4229043487A5072133977 @default.
- W4229043487 hasAuthorship W4229043487A5075447752 @default.
- W4229043487 hasAuthorship W4229043487A5080704061 @default.
- W4229043487 hasAuthorship W4229043487A5086664284 @default.
- W4229043487 hasAuthorship W4229043487A5087983244 @default.
- W4229043487 hasBestOaLocation W42290434871 @default.
- W4229043487 hasConcept C104317684 @default.
- W4229043487 hasConcept C121608353 @default.
- W4229043487 hasConcept C127561419 @default.
- W4229043487 hasConcept C150194340 @default.
- W4229043487 hasConcept C153911025 @default.
- W4229043487 hasConcept C178790620 @default.
- W4229043487 hasConcept C185592680 @default.
- W4229043487 hasConcept C190283241 @default.
- W4229043487 hasConcept C190727270 @default.
- W4229043487 hasConcept C33288867 @default.
- W4229043487 hasConcept C502942594 @default.
- W4229043487 hasConcept C540031477 @default.
- W4229043487 hasConcept C54355233 @default.
- W4229043487 hasConcept C55493867 @default.
- W4229043487 hasConcept C7836513 @default.
- W4229043487 hasConcept C81885089 @default.
- W4229043487 hasConcept C86803240 @default.