FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229043622> ?p ?o ?g. }

• W4229043622 endingPage "623" @default.
• W4229043622 startingPage "623" @default.
• W4229043622 abstract "To evaluate silver nanoparticles’ (AgNPs) therapeutic and clinical potentials, antibacterial action, blood compatibility, and antiplatelet activities are the main concerns for toxicity profiling. Heat-denatured lysozyme-mediated formulation stabilized the AgNPs, thereby providing more bactericidal activity and blood compatibility. The study of the synthesis of AgNPs suggests the rapid and cost-effective formulation of AgNPs by one-step reaction using a 10:1 ratio of silver nitrate and lysozyme by incubating at 60 °C for two hours. Characterization of AgNPs was analyzed by UV–Visible spectroscopy, DLS, TEM, EDX, XRD, AFM, and FTIR, followed by antibacterial, hemocompatibility, and platelet aggregation testing. The average size of synthesized AgNPs was found to be 94.10 nm with 0.45 mV zeta potential and 0.293 polydispersity index by DLS. The TEM and EXD results indicated homogeneously 28.08 nm spherical-shaped pure formations of AgNPs. The XRD peaks showed the synthesis of small AgNPs with a crystallite size of 22.88 nm, while the AFM confirmed the homogeneity and smoothness of the monodispersed AgNPs. The FTIR spectra specified the coating of the lysozyme-derived amide group on the AgNPs surface, which provides stability and functionality of nanoparticles. The antibacterial activity of AgNPs was remarkable against six pathogenic bacteria and three multidrug resistance (MDR) strains (i.e., Escherichia coli, Klebsiella aerogenes, and Pseudomonas aeruginosa), which exhibited inhibition zones with diameters ranging between 13.5 ± 0.2 mm to 19.0 ± 0.3 mm. The non-hemolytic nature of the AgNPs was calculated by percentage hemolysis with four concentrations. The negative result of platelet aggregation using platelet-rich plasma suggests the antiplatelet effect of AgNPs. Only minor hemolysis of 6.17% in human erythrocytes and mild platelet aggregation of 1.98% were induced, respectively, by the use of 1000 µL of 1 mM AgNPs, which contains approximately 107.8 μg silver. The results indicated that the antiplatelet potency and non-hemolytic nature with the antibacterial action of the lysozyme functionalized AgNPs have a good chance to be used to solve in-stent restenosis and thrombosis issues of the coronary stent and may also have a possibility to use in vaccination to resolve the blood clotting problem. So, the optimized biogenic formulation of AgNPs offers promising opportunities to be used as a therapeutic agent." @default.
• W4229043622 created "2022-05-08" @default.
• W4229043622 creator A5016914292 @default.
• W4229043622 creator A5017114487 @default.
• W4229043622 creator A5033607857 @default.
• W4229043622 creator A5037070179 @default.
• W4229043622 creator A5048608347 @default.
• W4229043622 creator A5053243975 @default.
• W4229043622 creator A5055289089 @default.
• W4229043622 creator A5064912999 @default.
• W4229043622 creator A5065954635 @default.
• W4229043622 creator A5073063880 @default.
• W4229043622 creator A5076542654 @default.
• W4229043622 date "2022-03-23" @default.
• W4229043622 modified "2023-09-26" @default.
• W4229043622 title "Biogenic Synthesis of Antibacterial, Hemocompatible, and Antiplatelets Lysozyme Functionalized Silver Nanoparticles through the One-Step Process for Therapeutic Applications" @default.
• W4229043622 cites W1796281808 @default.
• W4229043622 cites W1975088956 @default.
• W4229043622 cites W1977571062 @default.
• W4229043622 cites W1978635690 @default.
• W4229043622 cites W1979609777 @default.
• W4229043622 cites W1989153538 @default.
• W4229043622 cites W1990371302 @default.
• W4229043622 cites W1996192899 @default.
• W4229043622 cites W2025371519 @default.
• W4229043622 cites W2028375684 @default.
• W4229043622 cites W2034075250 @default.
• W4229043622 cites W2035423234 @default.
• W4229043622 cites W2037717119 @default.
• W4229043622 cites W2038653136 @default.
• W4229043622 cites W2051540815 @default.
• W4229043622 cites W2062061704 @default.
• W4229043622 cites W2068871963 @default.
• W4229043622 cites W2069403808 @default.
• W4229043622 cites W2080564816 @default.
• W4229043622 cites W2084438625 @default.
• W4229043622 cites W2088862518 @default.
• W4229043622 cites W2100457388 @default.
• W4229043622 cites W2103417732 @default.
• W4229043622 cites W2108974654 @default.
• W4229043622 cites W2128483286 @default.
• W4229043622 cites W2147397777 @default.
• W4229043622 cites W2150911019 @default.
• W4229043622 cites W2163151727 @default.
• W4229043622 cites W2170010832 @default.
• W4229043622 cites W2173133722 @default.
• W4229043622 cites W2221283327 @default.
• W4229043622 cites W2313345754 @default.
• W4229043622 cites W2315148676 @default.
• W4229043622 cites W2319122836 @default.
• W4229043622 cites W2330477746 @default.
• W4229043622 cites W2395109033 @default.
• W4229043622 cites W2462816253 @default.
• W4229043622 cites W2519678626 @default.
• W4229043622 cites W2549644565 @default.
• W4229043622 cites W2615753682 @default.
• W4229043622 cites W2618917988 @default.
• W4229043622 cites W2766566369 @default.
• W4229043622 cites W2801189740 @default.
• W4229043622 cites W2804323232 @default.
• W4229043622 cites W2804846127 @default.
• W4229043622 cites W2911517174 @default.
• W4229043622 cites W2955180832 @default.
• W4229043622 cites W2965604730 @default.
• W4229043622 cites W2971785329 @default.
• W4229043622 cites W2972753203 @default.
• W4229043622 cites W2987577263 @default.
• W4229043622 cites W3008494305 @default.
• W4229043622 cites W3032564875 @default.
• W4229043622 cites W3036620193 @default.
• W4229043622 cites W3113105815 @default.
• W4229043622 cites W3128682525 @default.
• W4229043622 cites W3170951675 @default.
• W4229043622 cites W3210668565 @default.
• W4229043622 cites W4205790954 @default.
• W4229043622 cites W4221013904 @default.
• W4229043622 cites W634160248 @default.
• W4229043622 doi "https://doi.org/10.3390/pr10040623" @default.
• W4229043622 hasPublicationYear "2022" @default.
• W4229043622 type Work @default.
• W4229043622 citedByCount "3" @default.
• W4229043622 countsByYear W42290436222022 @default.
• W4229043622 countsByYear W42290436222023 @default.
• W4229043622 crossrefType "journal-article" @default.
• W4229043622 hasAuthorship W4229043622A5016914292 @default.
• W4229043622 hasAuthorship W4229043622A5017114487 @default.
• W4229043622 hasAuthorship W4229043622A5033607857 @default.
• W4229043622 hasAuthorship W4229043622A5037070179 @default.
• W4229043622 hasAuthorship W4229043622A5048608347 @default.
• W4229043622 hasAuthorship W4229043622A5053243975 @default.
• W4229043622 hasAuthorship W4229043622A5055289089 @default.
• W4229043622 hasAuthorship W4229043622A5064912999 @default.
• W4229043622 hasAuthorship W4229043622A5065954635 @default.
• W4229043622 hasAuthorship W4229043622A5073063880 @default.
• W4229043622 hasAuthorship W4229043622A5076542654 @default.
• W4229043622 hasBestOaLocation W42290436221 @default.
• W4229043622 hasConcept C11432220 @default.
• W4229043622 hasConcept C127413603 @default.

• next