Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229044172> ?p ?o ?g. }
- W4229044172 endingPage "114106" @default.
- W4229044172 startingPage "114106" @default.
- W4229044172 abstract "Dopamine modulation is thought to underpin some of the therapeutic effects associated with repetitive transcranial magnetic stimulation (rTMS). However, patient studies have failed to demonstrate consistent changes in the dopamine system in vivo after a therapeutic course of rTMS. Here, we evaluated acute and chronic changes in striatal dopamine release elicited by a clinically relevant course of theta burst (TBS) or sham stimulation using [11C]raclopride in healthy non-human primates (n = 11). Subjects were scanned immediately after the first session of TBS and the day after a 3 week course of daily TBS delivery. After experiment completion, animals were euthanized, and immunofluorescence staining was carried out using antibodies targeting D2 receptors (D2R). Continuous TBS (cTBS, an inhibitory form of rTMS) over the left primary motor cortex acutely decreased dopamine release bilaterally in the putamen. However, no significant changes in dopamine receptors nor D2R immunoreactivity were noted 24 h after the last stimulation, while a decrease in cortical excitability, as measured by an increase in resting motor threshold, could still be quantified. On the opposite, intermittent TBS (iTBS, an excitatory form of rTMS) did not affect dopamine release, acutely or chronically, D2R immunoreactivity or cortical excitability. These findings suggest that the long-term therapeutic effects of TBS might be facilitated through the modulation of different neurotransmission systems beyond the dopamine system. However, given the small sample size, these results should be interpreted with caution." @default.
- W4229044172 created "2022-05-08" @default.
- W4229044172 creator A5009849874 @default.
- W4229044172 creator A5013821386 @default.
- W4229044172 creator A5063573000 @default.
- W4229044172 creator A5084411653 @default.
- W4229044172 creator A5088911615 @default.
- W4229044172 creator A5006871445 @default.
- W4229044172 date "2022-08-01" @default.
- W4229044172 modified "2023-10-12" @default.
- W4229044172 title "Continuous but not intermittent theta burst stimulation decreases striatal dopamine release and cortical excitability" @default.
- W4229044172 cites W1548443654 @default.
- W4229044172 cites W1860766246 @default.
- W4229044172 cites W1942509020 @default.
- W4229044172 cites W1942895563 @default.
- W4229044172 cites W1964701571 @default.
- W4229044172 cites W1966533161 @default.
- W4229044172 cites W1978713359 @default.
- W4229044172 cites W1982313674 @default.
- W4229044172 cites W1990701757 @default.
- W4229044172 cites W1990995690 @default.
- W4229044172 cites W1998351404 @default.
- W4229044172 cites W2003730746 @default.
- W4229044172 cites W2004731697 @default.
- W4229044172 cites W2007656061 @default.
- W4229044172 cites W2009326946 @default.
- W4229044172 cites W2009676467 @default.
- W4229044172 cites W2015701831 @default.
- W4229044172 cites W2018818798 @default.
- W4229044172 cites W2021775770 @default.
- W4229044172 cites W2028402362 @default.
- W4229044172 cites W2035628396 @default.
- W4229044172 cites W2037122495 @default.
- W4229044172 cites W2038642421 @default.
- W4229044172 cites W2041949619 @default.
- W4229044172 cites W2051682329 @default.
- W4229044172 cites W2054230322 @default.
- W4229044172 cites W2054929374 @default.
- W4229044172 cites W2055936245 @default.
- W4229044172 cites W2059329147 @default.
- W4229044172 cites W2061600599 @default.
- W4229044172 cites W2063062105 @default.
- W4229044172 cites W2063841517 @default.
- W4229044172 cites W2064311536 @default.
- W4229044172 cites W2064712388 @default.
- W4229044172 cites W2070726162 @default.
- W4229044172 cites W2076792446 @default.
- W4229044172 cites W2079190787 @default.
- W4229044172 cites W2079788582 @default.
- W4229044172 cites W2083770481 @default.
- W4229044172 cites W2083920471 @default.
- W4229044172 cites W2091631340 @default.
- W4229044172 cites W2094712734 @default.
- W4229044172 cites W2097311789 @default.
- W4229044172 cites W2099652807 @default.
- W4229044172 cites W2101333119 @default.
- W4229044172 cites W2102259310 @default.
- W4229044172 cites W2105987091 @default.
- W4229044172 cites W2106569650 @default.
- W4229044172 cites W2107250947 @default.
- W4229044172 cites W2109372640 @default.
- W4229044172 cites W2110173269 @default.
- W4229044172 cites W2114168755 @default.
- W4229044172 cites W2115131555 @default.
- W4229044172 cites W2118266586 @default.
- W4229044172 cites W2119156794 @default.
- W4229044172 cites W2124538150 @default.
- W4229044172 cites W2129241661 @default.
- W4229044172 cites W2131332233 @default.
- W4229044172 cites W2132480755 @default.
- W4229044172 cites W2136888049 @default.
- W4229044172 cites W2140358254 @default.
- W4229044172 cites W2150603122 @default.
- W4229044172 cites W2150857753 @default.
- W4229044172 cites W2157491597 @default.
- W4229044172 cites W2165661567 @default.
- W4229044172 cites W2278690177 @default.
- W4229044172 cites W2287057286 @default.
- W4229044172 cites W2517992311 @default.
- W4229044172 cites W2586383528 @default.
- W4229044172 cites W2613795476 @default.
- W4229044172 cites W2769478986 @default.
- W4229044172 cites W2792511487 @default.
- W4229044172 cites W2883570850 @default.
- W4229044172 cites W2915208184 @default.
- W4229044172 cites W2927682495 @default.
- W4229044172 cites W2946175450 @default.
- W4229044172 cites W2969587200 @default.
- W4229044172 cites W2972420026 @default.
- W4229044172 cites W2982076096 @default.
- W4229044172 cites W2997901555 @default.
- W4229044172 cites W3020778573 @default.
- W4229044172 cites W3112358509 @default.
- W4229044172 cites W3130250413 @default.
- W4229044172 cites W3137097389 @default.
- W4229044172 cites W3185313788 @default.
- W4229044172 cites W4205168524 @default.
- W4229044172 cites W565631165 @default.