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- W4229045163 abstract "Abstract In this paper we use simulation methods to investigate the proliferation of deletion mutations of mitochondrial DNA in neurons. We simulate three mtDNA proliferation mechanisms, namely, random drift, replicative advantage and vicious cycle. For each mechanism, we investigated the effect mutation rates have on neuron loss within a human host. We also compare heteroplasmy of each mechanism at mutation rates that yield the levels neuron loss that would be associated with dementia. Both random drift and vicious cycle predicted high levels of heteroplasmy, while replicative advantage showed a small number of dominant clones with a low background of heteroplasmy." @default.
- W4229045163 created "2022-05-08" @default.
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- W4229045163 date "2022-05-04" @default.
- W4229045163 modified "2023-10-16" @default.
- W4229045163 title "A comparison of mtDNA deletion mutant proliferation mechanisms" @default.
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- W4229045163 doi "https://doi.org/10.1101/2022.05.03.489489" @default.
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