FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229049069> ?p ?o ?g. }

• W4229049069 endingPage "4616" @default.
• W4229049069 startingPage "4606" @default.
• W4229049069 abstract "Single-chain lipid amphiphiles such as fatty acids and monoglycerides along with structurally related surfactants have received significant attention as membrane-disrupting antimicrobials to inhibit bacteria and viruses. Such promise has motivated deeper exploration of how these compounds disrupt phospholipid membranes, and the membrane-mimicking, supported lipid bilayer (SLB) platform has provided a useful model system to evaluate corresponding mechanisms of action and potency levels. Even so, it remains largely unknown how biologically relevant membrane properties, such as sub-100 nm membrane curvature, might affect these membrane-disruptive interactions, especially from a nanoarchitectonics perspective. Herein, using the quartz crystal microbalance-dissipation (QCM-D) technique, we fabricated intact vesicle adlayers composed of different-size vesicles (70 or 120 nm diameter) with varying degrees of membrane curvature on a titanium oxide surface and tracked changes in vesicle adlayer properties upon adding lauric acid (LA), glycerol monolaurate (GML), or sodium dodecyl sulfate (SDS). Above their critical micelle concentration (CMC) values, LA and GML caused QCM-D measurement shifts associated with tubule- and bud-like formation, respectively, and both compounds interacted similarly with small (high curvature) and large (low curvature) vesicles. In marked contrast, SDS exhibited distinct interactions with small and large vesicles. For large vesicles, SDS caused nearly complete membrane solubilization in a CMC-independent manner, whereas SDS was largely ineffective at solubilizing small vesicles at all tested concentrations. We rationalize these experimental observations by taking into account the interplay of the headgroup properties of LA, GML, and SDS and curvature-induced membrane geometry, and our findings demonstrate that membrane curvature nanoarchitectonics can strongly influence the membrane interaction profiles of antimicrobial lipids and surfactants." @default.
• W4229049069 created "2022-05-08" @default.
• W4229049069 creator A5024603134 @default.
• W4229049069 creator A5039717568 @default.
• W4229049069 creator A5087948924 @default.
• W4229049069 date "2022-04-07" @default.
• W4229049069 modified "2023-10-16" @default.
• W4229049069 title "Effect of Membrane Curvature Nanoarchitectonics on Membrane-Disruptive Interactions of Antimicrobial Lipids and Surfactants" @default.
• W4229049069 cites W1638339816 @default.
• W4229049069 cites W1964633700 @default.
• W4229049069 cites W1968823199 @default.
• W4229049069 cites W1972995661 @default.
• W4229049069 cites W1975037895 @default.
• W4229049069 cites W1980505972 @default.
• W4229049069 cites W1981998283 @default.
• W4229049069 cites W1986123213 @default.
• W4229049069 cites W1993745463 @default.
• W4229049069 cites W2005548841 @default.
• W4229049069 cites W2007651537 @default.
• W4229049069 cites W2021706112 @default.
• W4229049069 cites W2034199026 @default.
• W4229049069 cites W2034812849 @default.
• W4229049069 cites W2051213419 @default.
• W4229049069 cites W2051813582 @default.
• W4229049069 cites W2062123099 @default.
• W4229049069 cites W2063490423 @default.
• W4229049069 cites W2063742728 @default.
• W4229049069 cites W2066891217 @default.
• W4229049069 cites W2069716410 @default.
• W4229049069 cites W2070652409 @default.
• W4229049069 cites W2077745434 @default.
• W4229049069 cites W2083258595 @default.
• W4229049069 cites W2088643691 @default.
• W4229049069 cites W2092422149 @default.
• W4229049069 cites W2101223910 @default.
• W4229049069 cites W2110720975 @default.
• W4229049069 cites W2110826045 @default.
• W4229049069 cites W2116385303 @default.
• W4229049069 cites W2116452439 @default.
• W4229049069 cites W2133051117 @default.
• W4229049069 cites W2137827816 @default.
• W4229049069 cites W2155747892 @default.
• W4229049069 cites W2156825780 @default.
• W4229049069 cites W2318550064 @default.
• W4229049069 cites W2418479278 @default.
• W4229049069 cites W2502536698 @default.
• W4229049069 cites W2513860021 @default.
• W4229049069 cites W2530108800 @default.
• W4229049069 cites W2560784553 @default.
• W4229049069 cites W2594047882 @default.
• W4229049069 cites W2768107738 @default.
• W4229049069 cites W2796092742 @default.
• W4229049069 cites W2801198350 @default.
• W4229049069 cites W2810408649 @default.
• W4229049069 cites W2883749353 @default.
• W4229049069 cites W2897449839 @default.
• W4229049069 cites W2913898095 @default.
• W4229049069 cites W3008022732 @default.
• W4229049069 cites W3009747298 @default.
• W4229049069 cites W3020321104 @default.
• W4229049069 cites W3022636903 @default.
• W4229049069 cites W3030798113 @default.
• W4229049069 cites W3081982190 @default.
• W4229049069 cites W3097403934 @default.
• W4229049069 cites W3110750633 @default.
• W4229049069 cites W3112948501 @default.
• W4229049069 cites W3118251250 @default.
• W4229049069 cites W3127726407 @default.
• W4229049069 cites W3135493399 @default.
• W4229049069 cites W3176086946 @default.
• W4229049069 doi "https://doi.org/10.1021/acs.langmuir.1c03384" @default.
• W4229049069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35389653" @default.
• W4229049069 hasPublicationYear "2022" @default.
• W4229049069 type Work @default.
• W4229049069 citedByCount "6" @default.
• W4229049069 countsByYear W42290490692022 @default.
• W4229049069 countsByYear W42290490692023 @default.
• W4229049069 crossrefType "journal-article" @default.
• W4229049069 hasAuthorship W4229049069A5024603134 @default.
• W4229049069 hasAuthorship W4229049069A5039717568 @default.
• W4229049069 hasAuthorship W4229049069A5087948924 @default.
• W4229049069 hasConcept C11268172 @default.
• W4229049069 hasConcept C12554922 @default.
• W4229049069 hasConcept C130316041 @default.
• W4229049069 hasConcept C150394285 @default.
• W4229049069 hasConcept C178790620 @default.
• W4229049069 hasConcept C184651966 @default.
• W4229049069 hasConcept C185592680 @default.
• W4229049069 hasConcept C192157962 @default.
• W4229049069 hasConcept C2777278457 @default.
• W4229049069 hasConcept C2780943371 @default.
• W4229049069 hasConcept C39944091 @default.
• W4229049069 hasConcept C41625074 @default.
• W4229049069 hasConcept C43617362 @default.
• W4229049069 hasConcept C55493867 @default.
• W4229049069 hasConcept C86803240 @default.
• W4229049069 hasConcept C96347405 @default.
• W4229049069 hasConcept C9996572 @default.

• next