FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229051331> ?p ?o ?g. }

• W4229051331 endingPage "320" @default.
• W4229051331 startingPage "305" @default.
• W4229051331 abstract "Some depressed patients receive acupuncture as an adjunct to their conventional medications.This review aims to provide evidence on whether acupuncture can enhance the therapeutic effectiveness of antidepressants for treating depression, and explore whether acupuncture can reduce the adverse reactions associated with antidepressants.English and Chinese databases were searched for randomized controlled trials (RCTs) published until December 1, 2021.RCTs with a modified Jadad scale score ≥ 4 were included if they compared a group of participants with depression that received acupuncture combined with antidepressants with a control group that received antidepressants alone.Meta-analysis was performed, and statistical heterogeneity was assessed based on Cochran's Q statistic and its related P-value. Primary outcomes were the reduction in the severity of depression and adverse reactions associated with antidepressants, while secondary outcomes included remission rate, treatment response, social functioning, and change in antidepressant dose. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework was used to evaluate the overall quality of evidence in the included studies.This review included 16 studies (with a total of 1958 participants). Most studies were at high risk of performance bias and at low or unclear risk of selection bias, detection bias, attrition bias, reporting bias, and other bias. Analysis of the 16 RCTs showed that, compared with antidepressants alone, acupuncture along with antidepressants reduced the Hamilton Depression Rating Scale-17 (HAMD-17) scores (standard mean difference [SMD] -0.44, 95% confidence interval [CI] -0.55 to -0.33, P < 0.01; I2 = 14%), Self-rating Depression Scale (SDS) scores (SMD -0.53, 95% CI -0.84 to -0.23, P < 0.01; I2 = 79%), and the Side Effect Rating Scale (SERS) scores (SMD -1.11, 95% CI -1.56 to -0.66, P < 0.01; I2 = 89%). Compared with antidepressants alone, acupuncture along with antidepressants improved World Health Organization Quality of Life-BREF scores (SMD 0.31, 95% CI 0.18 to 0.44, P < 0.01; I2 = 15%), decreased the number of participants who increased their antidepressant dosages (relative risk [RR] 0.32, 95% CI 0.22 to 0.48, P < 0.01; I2 = 0%), and resulted in significantly higher remission rates (RR 1.52, 95% CI 1.26 to 1.83, P < 0.01; I2 = 0%) and treatment responses (RR 1.35, 95% CI 1.24 to 1.47, P < 0.01; I2 = 19%) in terms of HAMD-17 scores. The HAMD-17, SDS and SERS scores were assessed as low quality by GRADE and the other indices as being of moderate quality.Acupuncture as an adjunct to antidepressants may enhance the therapeutic effectiveness and reduce the adverse drug reactions in patients receiving antidepressants. These findings must be interpreted with caution, as the evidence was of low or moderate quality and there was a lack of comparative data with a placebo control.INPLASY202150008." @default.
• W4229051331 created "2022-05-08" @default.
• W4229051331 creator A5013123051 @default.
• W4229051331 creator A5029484872 @default.
• W4229051331 creator A5043382324 @default.
• W4229051331 creator A5045818052 @default.
• W4229051331 creator A5054837280 @default.
• W4229051331 creator A5055493887 @default.
• W4229051331 creator A5079077910 @default.
• W4229051331 creator A5085918263 @default.
• W4229051331 date "2022-07-01" @default.
• W4229051331 modified "2023-09-23" @default.
• W4229051331 title "Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis" @default.
• W4229051331 cites W122883157 @default.
• W4229051331 cites W1979275798 @default.
• W4229051331 cites W2006895116 @default.
• W4229051331 cites W2033530831 @default.
• W4229051331 cites W2037160399 @default.
• W4229051331 cites W2037867039 @default.
• W4229051331 cites W204046373 @default.
• W4229051331 cites W2049103906 @default.
• W4229051331 cites W2065678534 @default.
• W4229051331 cites W2070088741 @default.
• W4229051331 cites W2081212974 @default.
• W4229051331 cites W2090057913 @default.
• W4229051331 cites W2092303200 @default.
• W4229051331 cites W2097313012 @default.
• W4229051331 cites W2098923148 @default.
• W4229051331 cites W2114613490 @default.
• W4229051331 cites W2118085818 @default.
• W4229051331 cites W2134254973 @default.
• W4229051331 cites W2141673958 @default.
• W4229051331 cites W2155054485 @default.
• W4229051331 cites W2162196924 @default.
• W4229051331 cites W2165010366 @default.
• W4229051331 cites W2168718800 @default.
• W4229051331 cites W2170332928 @default.
• W4229051331 cites W2173456661 @default.
• W4229051331 cites W2224742922 @default.
• W4229051331 cites W2402600147 @default.
• W4229051331 cites W2463137216 @default.
• W4229051331 cites W2463733687 @default.
• W4229051331 cites W2485471030 @default.
• W4229051331 cites W2512630553 @default.
• W4229051331 cites W2516654568 @default.
• W4229051331 cites W2520169676 @default.
• W4229051331 cites W2558594905 @default.
• W4229051331 cites W2767793280 @default.
• W4229051331 cites W2788337440 @default.
• W4229051331 cites W2789439351 @default.
• W4229051331 cites W2794500250 @default.
• W4229051331 cites W2794707339 @default.
• W4229051331 cites W2801085490 @default.
• W4229051331 cites W2803352925 @default.
• W4229051331 cites W2885869279 @default.
• W4229051331 cites W2912654919 @default.
• W4229051331 cites W2939580427 @default.
• W4229051331 cites W2965806805 @default.
• W4229051331 cites W2978795816 @default.
• W4229051331 cites W2979221957 @default.
• W4229051331 cites W2982432777 @default.
• W4229051331 cites W2991170911 @default.
• W4229051331 cites W2996393987 @default.
• W4229051331 cites W3093830381 @default.
• W4229051331 cites W3106648151 @default.
• W4229051331 cites W3115364559 @default.
• W4229051331 cites W3118615836 @default.
• W4229051331 cites W3119889776 @default.
• W4229051331 cites W3195562489 @default.
• W4229051331 cites W4297681341 @default.
• W4229051331 cites W57359236 @default.
• W4229051331 doi "https://doi.org/10.1016/j.joim.2022.05.002" @default.
• W4229051331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35595611" @default.
• W4229051331 hasPublicationYear "2022" @default.
• W4229051331 type Work @default.
• W4229051331 citedByCount "6" @default.
• W4229051331 countsByYear W42290513312022 @default.
• W4229051331 countsByYear W42290513312023 @default.
• W4229051331 crossrefType "journal-article" @default.
• W4229051331 hasAuthorship W4229051331A5013123051 @default.
• W4229051331 hasAuthorship W4229051331A5029484872 @default.
• W4229051331 hasAuthorship W4229051331A5043382324 @default.
• W4229051331 hasAuthorship W4229051331A5045818052 @default.
• W4229051331 hasAuthorship W4229051331A5054837280 @default.
• W4229051331 hasAuthorship W4229051331A5055493887 @default.
• W4229051331 hasAuthorship W4229051331A5079077910 @default.
• W4229051331 hasAuthorship W4229051331A5085918263 @default.
• W4229051331 hasConcept C118552586 @default.
• W4229051331 hasConcept C126322002 @default.
• W4229051331 hasConcept C136524200 @default.
• W4229051331 hasConcept C138496976 @default.
• W4229051331 hasConcept C139719470 @default.
• W4229051331 hasConcept C142724271 @default.
• W4229051331 hasConcept C15744967 @default.
• W4229051331 hasConcept C162324750 @default.
• W4229051331 hasConcept C168563851 @default.
• W4229051331 hasConcept C1862650 @default.
• W4229051331 hasConcept C197934379 @default.

• next