FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229051657> ?p ?o ?g. }

• W4229051657 abstract "Abstract Background Heme oxygenase-1 (HO-1) gene promoter (GT)n dinucleotide repeat length variations may modify HIV-associated neurocognitive impairment (HIV-NCI) risk. Among adults, short HO-1 (GT)n alleles associate with greater HO-1 antioxidant enzyme inducibility and lower rates of HIV-NCI. This pilot study examined associations between HO-1 (GT)n alleles and neurocognitive outcomes in a sample of Thai youth (13-23 years) with perinatally-acquired HIV (PHIV) and demographically-matched HIV-negative controls. Methods Participants completed neurocognitive testing and provided blood samples for DNA extraction and sequencing of HO-1 promoter (GT)n dinucleotide repeat lengths. Allele lengths were assigned based on number of (GT)n repeats: <27 Short (S); 27-34 Medium (M); >34 Long (L). Relationships between HO-1 (GT)n repeat lengths and neurocognitive measures were examined, and differences by HO-1 (GT)n allele genotypes were explored. Results Nearly half (48%) of all HO-1 (GT)n promoter alleles were short. Longer repeat length of participants’ longest HO-1 (GT)n alleles significantly associated with poorer processing speed (Total sample: r =-.36, p =.01; PHIV only: r =-.69, p <.001). Compared to peers and controlling for covariates, SS/SM genotypes performed better in processing speed, and SS genotypes performed worse in working memory. Conclusions A high frequency of short HO-1 (GT)n alleles was found among these Thai youth, as previously observed in other cohorts of people of Asian ancestry. In contrast to previous adult studies, the presence of a short allele alone did not associate with better neurocognitive performance, suggesting additional modifying effects among the different alleles. Research is needed to determine whether HO-1 (GT)n promoter genotypes differentially influence neurocognitive functioning across the lifespan and different ethnic backgrounds." @default.
• W4229051657 created "2022-05-08" @default.
• W4229051657 creator A5009387687 @default.
• W4229051657 creator A5022609362 @default.
• W4229051657 creator A5043460359 @default.
• W4229051657 creator A5049873684 @default.
• W4229051657 creator A5056011405 @default.
• W4229051657 creator A5077045602 @default.
• W4229051657 creator A5078487246 @default.
• W4229051657 creator A5081328251 @default.
• W4229051657 creator A5088789437 @default.
• W4229051657 date "2022-04-26" @default.
• W4229051657 modified "2023-10-17" @default.
• W4229051657 title "Heme Oxygenase-1 Promoter (GT)n Alleles and Neurocognitive Functioning in Thai Youth with Perinatally-Acquired HIV: A Pilot Study" @default.
• W4229051657 cites W1162433512 @default.
• W4229051657 cites W1490906959 @default.
• W4229051657 cites W1978155055 @default.
• W4229051657 cites W1988766125 @default.
• W4229051657 cites W2006111626 @default.
• W4229051657 cites W2014439767 @default.
• W4229051657 cites W2021151285 @default.
• W4229051657 cites W2023332062 @default.
• W4229051657 cites W2025107286 @default.
• W4229051657 cites W2027069254 @default.
• W4229051657 cites W2032159980 @default.
• W4229051657 cites W2034995146 @default.
• W4229051657 cites W2037557484 @default.
• W4229051657 cites W2053739443 @default.
• W4229051657 cites W2061234464 @default.
• W4229051657 cites W2064703550 @default.
• W4229051657 cites W2071015953 @default.
• W4229051657 cites W2075367812 @default.
• W4229051657 cites W2079862395 @default.
• W4229051657 cites W2091599511 @default.
• W4229051657 cites W2094774474 @default.
• W4229051657 cites W2115168263 @default.
• W4229051657 cites W2115415365 @default.
• W4229051657 cites W2120370709 @default.
• W4229051657 cites W2125577155 @default.
• W4229051657 cites W2128847428 @default.
• W4229051657 cites W2130599091 @default.
• W4229051657 cites W2149738518 @default.
• W4229051657 cites W2162166621 @default.
• W4229051657 cites W2162224837 @default.
• W4229051657 cites W2162853795 @default.
• W4229051657 cites W2168459313 @default.
• W4229051657 cites W2295774726 @default.
• W4229051657 cites W2313186624 @default.
• W4229051657 cites W2315865150 @default.
• W4229051657 cites W2547666779 @default.
• W4229051657 cites W2620242306 @default.
• W4229051657 cites W2802982213 @default.
• W4229051657 cites W2906176630 @default.
• W4229051657 cites W2994956978 @default.
• W4229051657 cites W3015250769 @default.
• W4229051657 cites W3029928830 @default.
• W4229051657 cites W3103958170 @default.
• W4229051657 cites W3117138126 @default.
• W4229051657 cites W3133245374 @default.
• W4229051657 doi "https://doi.org/10.1101/2022.04.22.22274113" @default.
• W4229051657 hasPublicationYear "2022" @default.
• W4229051657 type Work @default.
• W4229051657 citedByCount "1" @default.
• W4229051657 countsByYear W42290516572023 @default.
• W4229051657 crossrefType "posted-content" @default.
• W4229051657 hasAuthorship W4229051657A5009387687 @default.
• W4229051657 hasAuthorship W4229051657A5022609362 @default.
• W4229051657 hasAuthorship W4229051657A5043460359 @default.
• W4229051657 hasAuthorship W4229051657A5049873684 @default.
• W4229051657 hasAuthorship W4229051657A5056011405 @default.
• W4229051657 hasAuthorship W4229051657A5077045602 @default.
• W4229051657 hasAuthorship W4229051657A5078487246 @default.
• W4229051657 hasAuthorship W4229051657A5081328251 @default.
• W4229051657 hasAuthorship W4229051657A5088789437 @default.
• W4229051657 hasBestOaLocation W42290516571 @default.
• W4229051657 hasConcept C104317684 @default.
• W4229051657 hasConcept C118552586 @default.
• W4229051657 hasConcept C135763542 @default.
• W4229051657 hasConcept C169900460 @default.
• W4229051657 hasConcept C172467417 @default.
• W4229051657 hasConcept C180754005 @default.
• W4229051657 hasConcept C181199279 @default.
• W4229051657 hasConcept C203014093 @default.
• W4229051657 hasConcept C2776217839 @default.
• W4229051657 hasConcept C2779219270 @default.
• W4229051657 hasConcept C3013748606 @default.
• W4229051657 hasConcept C54355233 @default.
• W4229051657 hasConcept C55493867 @default.
• W4229051657 hasConcept C71924100 @default.
• W4229051657 hasConcept C86803240 @default.
• W4229051657 hasConceptScore W4229051657C104317684 @default.
• W4229051657 hasConceptScore W4229051657C118552586 @default.
• W4229051657 hasConceptScore W4229051657C135763542 @default.
• W4229051657 hasConceptScore W4229051657C169900460 @default.
• W4229051657 hasConceptScore W4229051657C172467417 @default.
• W4229051657 hasConceptScore W4229051657C180754005 @default.
• W4229051657 hasConceptScore W4229051657C181199279 @default.
• W4229051657 hasConceptScore W4229051657C203014093 @default.
• W4229051657 hasConceptScore W4229051657C2776217839 @default.
• W4229051657 hasConceptScore W4229051657C2779219270 @default.

• next