FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229058228> ?p ?o ?g. }

• W4229058228 abstract "Abstract BACKGROUND AND AIMS Mineralocorticoid receptor antagonist treatment is kidney protective but not recommended in patients with advanced renal failure due to perceived risk of hyperkalaemia and death. The aim of the present study was to examine the impact of mineralocorticoid receptor antagonist treatment in progressive chronic kidney disease on risk of hyperkalaemia and to evaluate subsequent attributable mortality. METHOD Based on data from multiple nationwide health care registers, all Danish residents &gt;18 years with more than or equal to one recorded plasma creatinine measurement were identified in Denmark between 2008 and 2021, and followed until either incident hyperkalaemia &gt;6 mmol/L, death or end-of follow-up (5 October 2021). Cases were identified based on incident hyperkalaemia and subsequently matched with four controls without hyperkalaemia. eGFR was computed based on the latest creatinine measurement until 30 days prior to index using the CKD-EPI equation. Patients with no recorded creatinine measurement within 2 years until 30 days prior of index were excluded. Mineralocorticoid receptor antagonist associated susceptibility for hyperkalaemia was computed across strata of estimated glomerular filtration rate (eGFR) (&gt;60, 30–60 and &lt;30 mL/min/1.73 m2) in a conditional logistic regression model comparing rate of hyperkalaemia with stratification of baseline hazard rate by age, gender, diabetes and hypertension. Model fitting was accomplished using a nested case–control design with 1:4 risk-set matching of cases with age-, gender-, diabetes- and hypertension-matched controls. Subsequent risk of 30-day mortality was assessed in a retrospective cohort study including patients with hyperkalemia only. Patients were followed from the date of hyperkalemia until death, 30 days or end of follow-up (5 October 2021) with comparison of MRA-attributable mortality across strata of eGFR based on the Kaplan–Meier estimator and multiple Cox regression models adjusted for age and gender. RESULTS From a population of 4 255 962 Danish citizens with recorded plasma creatinine, a total of 51 775 patients with incident hyperkalaemia were identified between 2008 and 2021. Pre-existing plasma creatinine permitting estimation of renal function was available in 34 442 (66.5%) patients. The 34 442 cases with incident hyperkalaemia were matched 1:4 with 131 410 controls. Gender distribution was 57% male, median age was 73.5 (IQR 64.0–82.0) years and median eGFR was 74 (IQR 55–89) mL/min/1.73 m2. Mineralocorticoid receptor antagonist treatment was associated with increased rates of hyperkalaemia with HRs of 8.32 (95% CI: 7.82–8.85), 4.55 (95% CI: 4.26–4.86) and 2.00 (95% CI: 1.71–2.32) in patients with eGFR &gt; 60 mL/min/1.73 m2 eGFR 30–60 mL/min/1.73 m2 and eGFR &lt; 30 mL/min/1.73 m2 respectively (reference = No mineralocorticoid receptor antagonist treatment). 30-day mortality in patients with hyperkalaemia stratified on mineralocorticoid receptor antagonist treatment is shown in Figures 1 and 2. Overall, mineralocorticoid receptor antagonist treatment was associated with lower subsequent mortality: HR 0.84 (95% CI: 0.78–0.90); P &lt; 0.001, 0.67 (95% CI: 0.62–0.73); P &lt; 0.001 and 0.98 (95% CI: 0.86–1.1); P = 0.77 for eGFR &gt; 60 mL/min/1.73 m2 30–60 mL/min/1.73 m2 and &lt;30 mL/min/1.73 m2 respectively (reference = mineralocorticoid receptor antagonist). CONCLUSION Although mineralocorticoid receptor antagonist treatment was associated with increased risk of hyperkalaemia for all strata of kidney impairment, subsequent 30-day mortality was lower compared with patients with corresponding kidney function without mineralocorticoid receptor antagonist treatment." @default.
• W4229058228 created "2022-05-08" @default.
• W4229058228 creator A5030010426 @default.
• W4229058228 creator A5032789207 @default.
• W4229058228 creator A5058262020 @default.
• W4229058228 creator A5068682922 @default.
• W4229058228 creator A5070650168 @default.
• W4229058228 creator A5088555622 @default.
• W4229058228 date "2022-05-01" @default.
• W4229058228 modified "2023-09-27" @default.
• W4229058228 title "FC084: Mineralocorticoid Receptor Antagonist Treatment in Patients with Renal Insufficiency and Associated Risk of Hyperkalemia and Death" @default.
• W4229058228 doi "https://doi.org/10.1093/ndt/gfac115.004" @default.
• W4229058228 hasPublicationYear "2022" @default.
• W4229058228 type Work @default.
• W4229058228 citedByCount "0" @default.
• W4229058228 crossrefType "journal-article" @default.
• W4229058228 hasAuthorship W4229058228A5030010426 @default.
• W4229058228 hasAuthorship W4229058228A5032789207 @default.
• W4229058228 hasAuthorship W4229058228A5058262020 @default.
• W4229058228 hasAuthorship W4229058228A5068682922 @default.
• W4229058228 hasAuthorship W4229058228A5070650168 @default.
• W4229058228 hasAuthorship W4229058228A5088555622 @default.
• W4229058228 hasConcept C126322002 @default.
• W4229058228 hasConcept C134018914 @default.
• W4229058228 hasConcept C159641895 @default.
• W4229058228 hasConcept C189135053 @default.
• W4229058228 hasConcept C207103383 @default.
• W4229058228 hasConcept C2776069600 @default.
• W4229058228 hasConcept C2776379505 @default.
• W4229058228 hasConcept C2778198053 @default.
• W4229058228 hasConcept C2778525890 @default.
• W4229058228 hasConcept C2778653478 @default.
• W4229058228 hasConcept C2780243291 @default.
• W4229058228 hasConcept C2780306776 @default.
• W4229058228 hasConcept C44249647 @default.
• W4229058228 hasConcept C50382708 @default.
• W4229058228 hasConcept C71924100 @default.
• W4229058228 hasConceptScore W4229058228C126322002 @default.
• W4229058228 hasConceptScore W4229058228C134018914 @default.
• W4229058228 hasConceptScore W4229058228C159641895 @default.
• W4229058228 hasConceptScore W4229058228C189135053 @default.
• W4229058228 hasConceptScore W4229058228C207103383 @default.
• W4229058228 hasConceptScore W4229058228C2776069600 @default.
• W4229058228 hasConceptScore W4229058228C2776379505 @default.
• W4229058228 hasConceptScore W4229058228C2778198053 @default.
• W4229058228 hasConceptScore W4229058228C2778525890 @default.
• W4229058228 hasConceptScore W4229058228C2778653478 @default.
• W4229058228 hasConceptScore W4229058228C2780243291 @default.
• W4229058228 hasConceptScore W4229058228C2780306776 @default.
• W4229058228 hasConceptScore W4229058228C44249647 @default.
• W4229058228 hasConceptScore W4229058228C50382708 @default.
• W4229058228 hasConceptScore W4229058228C71924100 @default.
• W4229058228 hasIssue "Supplement_3" @default.
• W4229058228 hasLocation W42290582281 @default.
• W4229058228 hasOpenAccess W4229058228 @default.
• W4229058228 hasPrimaryLocation W42290582281 @default.
• W4229058228 hasRelatedWork W1971595373 @default.
• W4229058228 hasRelatedWork W1988863926 @default.
• W4229058228 hasRelatedWork W2037408526 @default.
• W4229058228 hasRelatedWork W2040844633 @default.
• W4229058228 hasRelatedWork W2072829430 @default.
• W4229058228 hasRelatedWork W2079787384 @default.
• W4229058228 hasRelatedWork W2098249099 @default.
• W4229058228 hasRelatedWork W2168712739 @default.
• W4229058228 hasRelatedWork W2312942238 @default.
• W4229058228 hasRelatedWork W3178083733 @default.
• W4229058228 hasVolume "37" @default.
• W4229058228 isParatext "false" @default.
• W4229058228 isRetracted "false" @default.
• W4229058228 workType "article" @default.