FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229061034> ?p ?o ?g. }

• W4229061034 abstract "Pituitary adenomas (PA) affect ~ 1:1200 of the population and can cause a wide range of symptoms due to hormone over-secretion, loss of normal pituitary gland function and/or compression of visual pathways, resulting in significantly impaired quality of life. Surgery is potentially curative if the location of the adenoma can be determined. However, standard structural (anatomical) imaging, in the form of MRI, is unable to locate all tumors, especially microadenomas (< 1 cm diameter). In such cases, functional imaging [11C-methionine PET/CT (Met-PET)] can facilitate tumor detection, although may be inconclusive when the adenoma is less metabolically active. We, therefore, explored whether subtraction imaging, comparing findings between two Met-PET scans with medical therapy-induced suppression of tumor activity in the intervening period, could increase confidence in adenoma localization. In addition, we assessed whether normalization to a reference region improved consistency of pituitary gland signal in healthy volunteers who underwent two Met-PET scans without medical suppression.We found that the mean percentage differences in maximum pituitary uptake between two Met-PET scans in healthy volunteers were 2.4% for (SUVr) [cerebellum], 8.8% for SUVr [pons], 5.2% for SUVr [gray matter] and 23.1% for the SUVbw [no region]. Laterality, as measured by contrast-noise ratio (CNR), indicated the correct location of the adenoma in all three image types with mean CNR values of 6.2, 8.1 and 11.1 for SUVbw, SUVbwSub and SUVrSub [cerebellum], respectively. Subtraction imaging improved CNR in 60% and 100% of patients when using images generated from SUVbw [no region] and SUVr [cerebellum] scans compared to standard clinical SUVbw imaging.Met-PET scans should be normalized to the cerebellum to minimize the effects of physiological variation in pituitary gland uptake of 11C-methionine, especially when comparing serial imaging. Subtraction imaging following endocrine suppression of tumor function improved lateralization of PA when compared with single time point clinical Met-PET but, importantly, only if the images were normalized to the cerebellum prior to subtraction." @default.
• W4229061034 created "2022-05-08" @default.
• W4229061034 creator A5009449020 @default.
• W4229061034 creator A5011266932 @default.
• W4229061034 creator A5014713865 @default.
• W4229061034 creator A5024562508 @default.
• W4229061034 creator A5032536696 @default.
• W4229061034 creator A5033661501 @default.
• W4229061034 creator A5035566438 @default.
• W4229061034 creator A5038946529 @default.
• W4229061034 creator A5040685164 @default.
• W4229061034 creator A5059126498 @default.
• W4229061034 creator A5063847780 @default.
• W4229061034 creator A5067370103 @default.
• W4229061034 creator A5069412084 @default.
• W4229061034 creator A5073106718 @default.
• W4229061034 creator A5083865012 @default.
• W4229061034 creator A5086264202 @default.
• W4229061034 creator A5090067557 @default.
• W4229061034 date "2022-05-07" @default.
• W4229061034 modified "2023-10-16" @default.
• W4229061034 title "Localization of TSH-secreting pituitary adenoma using 11C-methionine image subtraction" @default.
• W4229061034 cites W1516024084 @default.
• W4229061034 cites W1545364883 @default.
• W4229061034 cites W1966697842 @default.
• W4229061034 cites W2018251133 @default.
• W4229061034 cites W2026616100 @default.
• W4229061034 cites W2030087863 @default.
• W4229061034 cites W2055165520 @default.
• W4229061034 cites W2070712385 @default.
• W4229061034 cites W2110375644 @default.
• W4229061034 cites W2112881675 @default.
• W4229061034 cites W2127738340 @default.
• W4229061034 cites W2151409134 @default.
• W4229061034 cites W2155465275 @default.
• W4229061034 cites W2269177682 @default.
• W4229061034 cites W2280031334 @default.
• W4229061034 cites W2294458392 @default.
• W4229061034 cites W2535314257 @default.
• W4229061034 cites W2904929619 @default.
• W4229061034 cites W2947651443 @default.
• W4229061034 cites W2985194315 @default.
• W4229061034 cites W2995999682 @default.
• W4229061034 cites W3041127110 @default.
• W4229061034 cites W3047587412 @default.
• W4229061034 cites W3092120934 @default.
• W4229061034 cites W3123254987 @default.
• W4229061034 doi "https://doi.org/10.1186/s13550-022-00899-7" @default.
• W4229061034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35524902" @default.
• W4229061034 hasPublicationYear "2022" @default.
• W4229061034 type Work @default.
• W4229061034 citedByCount "3" @default.
• W4229061034 countsByYear W42290610342022 @default.
• W4229061034 countsByYear W42290610342023 @default.
• W4229061034 crossrefType "journal-article" @default.
• W4229061034 hasAuthorship W4229061034A5009449020 @default.
• W4229061034 hasAuthorship W4229061034A5011266932 @default.
• W4229061034 hasAuthorship W4229061034A5014713865 @default.
• W4229061034 hasAuthorship W4229061034A5024562508 @default.
• W4229061034 hasAuthorship W4229061034A5032536696 @default.
• W4229061034 hasAuthorship W4229061034A5033661501 @default.
• W4229061034 hasAuthorship W4229061034A5035566438 @default.
• W4229061034 hasAuthorship W4229061034A5038946529 @default.
• W4229061034 hasAuthorship W4229061034A5040685164 @default.
• W4229061034 hasAuthorship W4229061034A5059126498 @default.
• W4229061034 hasAuthorship W4229061034A5063847780 @default.
• W4229061034 hasAuthorship W4229061034A5067370103 @default.
• W4229061034 hasAuthorship W4229061034A5069412084 @default.
• W4229061034 hasAuthorship W4229061034A5073106718 @default.
• W4229061034 hasAuthorship W4229061034A5083865012 @default.
• W4229061034 hasAuthorship W4229061034A5086264202 @default.
• W4229061034 hasAuthorship W4229061034A5090067557 @default.
• W4229061034 hasBestOaLocation W42290610341 @default.
• W4229061034 hasConcept C126322002 @default.
• W4229061034 hasConcept C126838900 @default.
• W4229061034 hasConcept C134018914 @default.
• W4229061034 hasConcept C2777428134 @default.
• W4229061034 hasConcept C2777658017 @default.
• W4229061034 hasConcept C2779318953 @default.
• W4229061034 hasConcept C2989005 @default.
• W4229061034 hasConcept C33923547 @default.
• W4229061034 hasConcept C68060419 @default.
• W4229061034 hasConcept C71315377 @default.
• W4229061034 hasConcept C71924100 @default.
• W4229061034 hasConcept C94375191 @default.
• W4229061034 hasConceptScore W4229061034C126322002 @default.
• W4229061034 hasConceptScore W4229061034C126838900 @default.
• W4229061034 hasConceptScore W4229061034C134018914 @default.
• W4229061034 hasConceptScore W4229061034C2777428134 @default.
• W4229061034 hasConceptScore W4229061034C2777658017 @default.
• W4229061034 hasConceptScore W4229061034C2779318953 @default.
• W4229061034 hasConceptScore W4229061034C2989005 @default.
• W4229061034 hasConceptScore W4229061034C33923547 @default.
• W4229061034 hasConceptScore W4229061034C68060419 @default.
• W4229061034 hasConceptScore W4229061034C71315377 @default.
• W4229061034 hasConceptScore W4229061034C71924100 @default.
• W4229061034 hasConceptScore W4229061034C94375191 @default.
• W4229061034 hasFunder F4320319990 @default.
• W4229061034 hasIssue "1" @default.
• W4229061034 hasLocation W42290610341 @default.

• next