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• W4229064024 endingPage "192" @default.
• W4229064024 startingPage "174" @default.
• W4229064024 abstract "Neuropathic and inflammatory pain are major clinical challenges due to their ambiguous mechanisms and limited treatment approaches. N-methyl-D-aspartate receptor (NMDAR) and calcium-calmodulin-dependent protein kinase II (CaMKII) are responsible for nerve system sensation and are required for the induction and maintenance of pain. However, the roles of NMDAR and CaMKII in regulating orofacial pain are still less well known. Here, we established a neuropathic pain model by transecting a mouse inferior alveolar nerve (IAN) and an inflammatory pain model by injecting complete Freund's adjuvant (CFA) into its whisker pad. The Cre/loxp site-specific recombination system was used to conditionally knock out (KO) NR2B in the trigeminal ganglion (TG). Von Frey filament behavioral tests showed that IANX and CFA-induced mechanical allodynia were altered in NR2B-deficient mice. CFA upregulated CaMKIIα and CaMKIIβ in the mouse TG and spinal trigeminal caudate nucleus (SpVc). CaMKIIα first decreased and then increased in the TG after IANX, and CaMKIIβ decreased in the TG and SpVc. CFA and IANX both greatly enhanced the expression of phospho (p)-NR2B, p-CaMKII, cyclic adenosine monophosphate (cAMP), p-ERK, and p-cAMP response element binding protein (CREB) in the TG and SpVc. These neurochemical signal pathway alterations were reversed by the conditional KO of NR2B and inhibition of CaMKII. Similarly, IANX- and CFA-related behavioral alterations were reversed by intra-ganglionic (i.g.) -application of inhibitors of CaMKII, cAMP, and ERK. These findings revealed novel molecular signaling pathways (NR2B-CaMKII-cAMP-ERK-CREB) in the TG- and SpVc-derived latent subsequent peripheral and spinal central sensitization under nerve injury and inflammation, which might be beneficial for the treatment of orofacial allodynia." @default.
• W4229064024 created "2022-05-08" @default.
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• W4229064024 date "2022-07-01" @default.
• W4229064024 modified "2023-10-14" @default.
• W4229064024 title "Activation of the N-methyl-D-aspartate receptor contributes to orofacial neuropathic and inflammatory allodynia by facilitating calcium-calmodulin-dependent protein kinase II phosphorylation in mice" @default.
• W4229064024 cites W1528138794 @default.
• W4229064024 cites W1917894349 @default.
• W4229064024 cites W1965453901 @default.
• W4229064024 cites W1966556202 @default.
• W4229064024 cites W1975311573 @default.
• W4229064024 cites W1978082674 @default.
• W4229064024 cites W1983859789 @default.
• W4229064024 cites W1985527563 @default.
• W4229064024 cites W2003869576 @default.
• W4229064024 cites W2009905731 @default.
• W4229064024 cites W2012130997 @default.
• W4229064024 cites W2016560481 @default.
• W4229064024 cites W2019971616 @default.
• W4229064024 cites W2024380057 @default.
• W4229064024 cites W2029969214 @default.
• W4229064024 cites W2040318996 @default.
• W4229064024 cites W2043678803 @default.
• W4229064024 cites W2047470842 @default.
• W4229064024 cites W2048256601 @default.
• W4229064024 cites W2051520373 @default.
• W4229064024 cites W2057041663 @default.
• W4229064024 cites W2071495819 @default.
• W4229064024 cites W2073035767 @default.
• W4229064024 cites W2077358692 @default.
• W4229064024 cites W2078745238 @default.
• W4229064024 cites W2080360331 @default.
• W4229064024 cites W2087937006 @default.
• W4229064024 cites W2088677918 @default.
• W4229064024 cites W2098015915 @default.
• W4229064024 cites W2108222103 @default.
• W4229064024 cites W2121026252 @default.
• W4229064024 cites W2128469846 @default.
• W4229064024 cites W2128690456 @default.
• W4229064024 cites W2135164856 @default.
• W4229064024 cites W2146732533 @default.
• W4229064024 cites W2148023161 @default.
• W4229064024 cites W2150571811 @default.
• W4229064024 cites W2157934436 @default.
• W4229064024 cites W2165104370 @default.
• W4229064024 cites W2183477133 @default.
• W4229064024 cites W2269725538 @default.
• W4229064024 cites W2314330399 @default.
• W4229064024 cites W2415355358 @default.
• W4229064024 cites W2473280865 @default.
• W4229064024 cites W2488808869 @default.
• W4229064024 cites W2516292063 @default.
• W4229064024 cites W2547805611 @default.
• W4229064024 cites W2560421166 @default.
• W4229064024 cites W257920779 @default.
• W4229064024 cites W2586241300 @default.
• W4229064024 cites W2594459623 @default.
• W4229064024 cites W2595054512 @default.
• W4229064024 cites W2734969944 @default.
• W4229064024 cites W2746455329 @default.
• W4229064024 cites W2751168377 @default.
• W4229064024 cites W2755379397 @default.
• W4229064024 cites W2770104614 @default.
• W4229064024 cites W2787669991 @default.
• W4229064024 cites W2793983403 @default.
• W4229064024 cites W2800776893 @default.
• W4229064024 cites W2804368056 @default.
• W4229064024 cites W2807499669 @default.
• W4229064024 cites W2883411848 @default.
• W4229064024 cites W2912090287 @default.
• W4229064024 cites W2921338803 @default.
• W4229064024 cites W2940735269 @default.
• W4229064024 cites W2943412858 @default.
• W4229064024 cites W2984950913 @default.
• W4229064024 cites W3006088950 @default.
• W4229064024 cites W3007415240 @default.
• W4229064024 cites W3008129643 @default.
• W4229064024 cites W3011273722 @default.
• W4229064024 cites W3014105084 @default.
• W4229064024 cites W3015000286 @default.
• W4229064024 cites W3111039654 @default.
• W4229064024 cites W3121645394 @default.
• W4229064024 doi "https://doi.org/10.1016/j.brainresbull.2022.05.003" @default.
• W4229064024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35537568" @default.
• W4229064024 hasPublicationYear "2022" @default.
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