Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229069093> ?p ?o ?g. }
- W4229069093 abstract "Cadherins contribute to the organization of nearly all tissues, but the functions of several evolutionarily conserved cadherins, including those of calsyntenins, remain enigmatic. Puzzlingly, two distinct, non-overlapping functions for calsyntenins were proposed: As postsynaptic neurexin ligands in synapse formation, or as presynaptic kinesin adaptors in vesicular transport. Here, we show that, surprisingly, acute CRISPR-mediated deletion of calsyntenin-3 in mouse cerebellum in vivo causes a large decrease in inhibitory synapse, but a robust increase in excitatory parallel-fiber synapses in Purkinje cells. As a result, inhibitory synaptic transmission was suppressed, whereas parallel-fiber synaptic transmission was enhanced in Purkinje cells by the calsyntenin-3 deletion. No changes in the dendritic architecture of Purkinje cells or in climbing-fiber synapses were detected. Sparse selective deletion of calsyntenin-3 only in Purkinje cells recapitulated the synaptic phenotype, indicating that calsyntenin-3 acts by a cell-autonomous postsynaptic mechanism in cerebellum. Thus, by inhibiting formation of excitatory parallel-fiber synapses and promoting formation of inhibitory synapses in the same neuron, calsyntenin-3 functions as a postsynaptic adhesion molecule that regulates the excitatory/inhibitory balance in Purkinje cells." @default.
- W4229069093 created "2022-05-08" @default.
- W4229069093 creator A5011117328 @default.
- W4229069093 creator A5019010463 @default.
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- W4229069093 creator A5034257539 @default.
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- W4229069093 creator A5063359584 @default.
- W4229069093 creator A5080227371 @default.
- W4229069093 date "2022-04-14" @default.
- W4229069093 modified "2023-10-01" @default.
- W4229069093 title "Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum" @default.
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- W4229069093 doi "https://doi.org/10.7554/elife.70664" @default.
- W4229069093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35420982" @default.
- W4229069093 hasPublicationYear "2022" @default.