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• W4229069254 startingPage "103784" @default.
• W4229069254 abstract "The heterochronic microRNA let-7, which was first identified in Caenorhabditis elegans, controls the timing of developmental programs, and let-7 triggers the onset of the juvenile-adult transition in bilaterians. The expression of let-7 is strongly induced during the last larval stage of C. elegans and is highly expressed in the late last instar larvae/nymphs of the fly Drosophila melanogaster and the cockroach Blattella germanica. In the silkworm Bombyx mori, the expression of let-7 remarkably increases in the corpus cardiacum-corpus allatum complex (CC-CA) at the beginning of the last larval instar and is maintained at high levels during this instar. To determine the biological function of let-7 in B. mori, we generated a let-7 knockout line and a transgenic UAS-let-7 line. The let-7 knockout larvae were developmentally arrested in the prepupal stage and became pupal-adult intermediates after apolysis. When let-7 was ubiquitously overexpressed under the transcriptional control of an Actin3-GAL4 driver, developmental timing and growth of larvae were severely impaired in the penultimate (L4) instar, and these larvae underwent precocious metamorphosis from L4. Furthermore, our results showed that reception and signaling of ecdysteroids and juvenile hormones (JHs) normally occurred in the absence of let-7, whereas the biosynthesis of ecdysone and JHs were affected by disruption and overexpression of let-7. Together, the present study demonstrates that let-7 is required for the coordination of the biosynthesis of ecdysone and JH to ensure the developmental transition during the metamorphosis of B. mori." @default.
• W4229069254 created "2022-05-08" @default.
• W4229069254 creator A5005965365 @default.
• W4229069254 creator A5064036671 @default.
• W4229069254 creator A5080756133 @default.
• W4229069254 date "2022-06-01" @default.
• W4229069254 modified "2023-10-17" @default.
• W4229069254 title "MicroRNA let-7 is required for hormonal regulation of metamorphosis in the silkworm, Bombyx mori" @default.
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• W4229069254 doi "https://doi.org/10.1016/j.ibmb.2022.103784" @default.
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