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- W4229069504 abstract "Although proton irradiation is ubiquitous in outer space as well as in the treatment of human diseases, its effects remain largely unclear. This work aimed to investigate and compare the composition of gut microbiota composition of mice in different species exposed to high-dose radiation. Male Balb/c mice and C57BL/6J mice were irradiated at a high dose (5Gy). Fecal specimens before and after irradiation were subjected to high-throughput sequencing (HTS) for the amplification of 16S rRNA gene sequences. We observed substantial changes in gut microbial composition among mice irradiated at high doses compared to non-irradiated controls. The changes included both the alpha and beta diversities. Furthermore, there were 11 distinct alterations in the irradiation group compared to the non-radiation control, including the families Muribaculaceae, Ruminococcaceae, Lactobacillus, Lachnospiraceae_NK4A136, Bacteroides, Alistipes, Clostridiales, Muribaculum, and Alloprevotella. Such alterations in the gut microbiome were accompanied by alterations in metabolite abundances, while at the metabolic level, 32 metabolites were likely to be potential biomarkers. Some alterations may have a positive effect on the repair of intestinal damage. Simultaneously, metabolites were predicted to involve multiple signal pathways, such as Urea Cycle, Ammonia Recycling, Alpha Linolenic Acid and Linoleic Acid Metabolism, Ketone Body Metabolism, Aspartate Metabolism, Phenylacetate Metabolism, Malate-Aspartate Shuttle, Arginine and Proline Metabolism and Carnitine Synthesis. Metabolites produced by proton irradiation in the microbial region play a positive role in repairing damage, making this area worthy of further experimental exploration. The present work offers an analytical and theoretical foundation to investigate how proton radiation affects the treatment of human diseases and identifies potential biomarkers to address the adverse effects of radiation.The space radiation environment is extremely complex, protons radiation is still the main component of space radiation and play an important role in space radiation. We proposed for the first time to compare the feces of Balb/c and C57BL/6J mice to study the changes of intestinal flora before and after proton irradiation. However, the effect of proton irradiation on the gut microbiome of both types of mice has not been previously demonstrated. After proton irradiation in two kinds of mice, we found that the characteristics of intestinal microbiome were related to the repair of intestinal injury, and some metabolites played a positive role in the repair of intestinal injury." @default.
- W4229069504 created "2022-05-08" @default.
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- W4229069504 date "2022-05-06" @default.
- W4229069504 modified "2023-10-18" @default.
- W4229069504 title "Differences in the Establishment of Gut Microbiota and Metabolome Characteristics Between Balb/c and C57BL/6J Mice After Proton Irradiation" @default.
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- W4229069504 cites W1977657064 @default.
- W4229069504 cites W1985672713 @default.
- W4229069504 cites W1999615949 @default.
- W4229069504 cites W2010748592 @default.
- W4229069504 cites W2022321694 @default.
- W4229069504 cites W2023627397 @default.
- W4229069504 cites W2025947455 @default.
- W4229069504 cites W2026227912 @default.
- W4229069504 cites W2048647257 @default.
- W4229069504 cites W2070263689 @default.
- W4229069504 cites W2078851020 @default.
- W4229069504 cites W2080984707 @default.
- W4229069504 cites W2088192427 @default.
- W4229069504 cites W2095143501 @default.
- W4229069504 cites W2107224596 @default.
- W4229069504 cites W2114577231 @default.
- W4229069504 cites W2118216866 @default.
- W4229069504 cites W2119550028 @default.
- W4229069504 cites W2122704890 @default.
- W4229069504 cites W2124435581 @default.
- W4229069504 cites W2133856765 @default.
- W4229069504 cites W2134258634 @default.
- W4229069504 cites W2138849309 @default.
- W4229069504 cites W2145518812 @default.
- W4229069504 cites W2210538740 @default.
- W4229069504 cites W2310594086 @default.
- W4229069504 cites W2408236488 @default.
- W4229069504 cites W2520046468 @default.
- W4229069504 cites W2563720483 @default.
- W4229069504 cites W2586127765 @default.
- W4229069504 cites W2737087640 @default.
- W4229069504 cites W2746539201 @default.
- W4229069504 cites W2766013963 @default.
- W4229069504 cites W2885020156 @default.
- W4229069504 cites W2893184302 @default.
- W4229069504 cites W2903174799 @default.
- W4229069504 cites W2920543106 @default.
- W4229069504 cites W2935729522 @default.
- W4229069504 cites W2948909067 @default.
- W4229069504 cites W2968882654 @default.
- W4229069504 cites W2969373712 @default.
- W4229069504 cites W2998896937 @default.
- W4229069504 cites W3010814544 @default.
- W4229069504 cites W3012051758 @default.
- W4229069504 cites W3014424623 @default.
- W4229069504 cites W3017000664 @default.
- W4229069504 cites W3026587634 @default.
- W4229069504 cites W3028606632 @default.
- W4229069504 cites W3034010557 @default.
- W4229069504 cites W3036014247 @default.
- W4229069504 cites W3036112679 @default.
- W4229069504 cites W3041891326 @default.
- W4229069504 cites W3041934953 @default.
- W4229069504 cites W3084294713 @default.
- W4229069504 cites W3094291887 @default.
- W4229069504 cites W3103448702 @default.
- W4229069504 cites W3115877858 @default.
- W4229069504 cites W3120110288 @default.
- W4229069504 cites W3126436367 @default.
- W4229069504 cites W3130452549 @default.
- W4229069504 cites W3142449179 @default.
- W4229069504 cites W3147376412 @default.
- W4229069504 cites W3150323554 @default.
- W4229069504 cites W3156729499 @default.
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- W4229069504 doi "https://doi.org/10.3389/fmicb.2022.874702" @default.
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