FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229070175> ?p ?o ?g. }

• W4229070175 endingPage "115209" @default.
• W4229070175 startingPage "115209" @default.
• W4229070175 abstract "The Luobufukebiri pill is one of the characteristic medicines of Uygur nationality in Xinjiang. It has the effect of warming and tonifying the brain and kidney, benefiting the heart and filling the essential functions, mainly used to treat impotence, depression, spermatorrhea, premature ejaculation, bodily weakness, emaciation, and neurasthenia.This study evaluated the toxicology and developed a quality control protocol of Luobufukebiri pill to ensure its safety and effectiveness in clinical applications.Acute toxicity in mice was studied by the maximum-dose method, and the toxic reactions in mice were observed within two weeks. In the study of Sub-chronic toxicity, SD rats were randomized into four groups: three drug groups which were treated with 8.00, 2.67, and 0.80 g/kg of Luobufukebiri pill, respectively, and one control group which was treated with the same volume of distilled water. Subsequently, at 30 days of medication and 30 days of drug withdrawal, the hematologic indexes, biochemical indexes, organ coefficient, and pathological sections of main organs were detected, respectively. According to the prescription, the contents of 8 active components in the pill were quantified simultaneously. The chromatographic conditions were as follows: Stepwise gradient elution was carried out using 0.1% formic acid (solvent A) and acetonitrile (solvent B), 0-8 min, 80% → 60% B; 8-25 min, 60% → 25%B. The flow rate was 1.0 mL/min, the column was maintained at 25 °C, and the injected sample volume was 10 μL.The acute toxicity experiment documented a large dose of Luobufukebiri pill had no significant effect on organ and body weight and did not cause apparent damage to parenchymal organs. At Sub-chronic toxicity, the behavior of rats was as normal as the control group. There were some differences in hematologic indexes, serum biochemical indexes, and organ coefficient tests between the drug and control groups, but they had no toxic significance. No obvious pathological changes were observed in the pathological sections of major organs. In conclusion, this study demonstrated that the clinical dose of Luobufukebiri pill was far less than its toxic dose, and it had reliable safety. The contents of eight index components of Luobufukebiri pill were measured. All calibration curves exhibited good linearity with correlation coefficients better than 0.9997. The relative standard deviations of precision, reproducibility, stability, and recovery were less than 2.0%, demonstrating the stability and reliability of the method.This study further confirmed the safety of Luobufukebiri pill in clinical practice. A rapid, accurate, and convenient RP-HPLC-PDA detection method has been developed for the simultaneous detection of eight active compounds in the pharmaceutical samples of Luobufukebiri pill. This study provided a reference for the safety and enhancement of the quality standards of Luobufukebiri pill." @default.
• W4229070175 created "2022-05-08" @default.
• W4229070175 creator A5005553424 @default.
• W4229070175 creator A5009050901 @default.
• W4229070175 creator A5053204257 @default.
• W4229070175 creator A5065970192 @default.
• W4229070175 creator A5068735424 @default.
• W4229070175 creator A5082893297 @default.
• W4229070175 creator A5083588969 @default.
• W4229070175 creator A5085331622 @default.
• W4229070175 date "2022-08-01" @default.
• W4229070175 modified "2023-09-23" @default.
• W4229070175 title "Evaluation of toxicological safety and quality control of Luobufukebiri pill" @default.
• W4229070175 cites W1981892952 @default.
• W4229070175 cites W1996890362 @default.
• W4229070175 cites W2001031888 @default.
• W4229070175 cites W2010281379 @default.
• W4229070175 cites W2016185211 @default.
• W4229070175 cites W2040061506 @default.
• W4229070175 cites W2055393668 @default.
• W4229070175 cites W2058058299 @default.
• W4229070175 cites W2064985187 @default.
• W4229070175 cites W2086912965 @default.
• W4229070175 cites W2157412052 @default.
• W4229070175 cites W2164128399 @default.
• W4229070175 cites W2236567779 @default.
• W4229070175 cites W2426860693 @default.
• W4229070175 cites W2551154560 @default.
• W4229070175 cites W2729783724 @default.
• W4229070175 cites W2730334749 @default.
• W4229070175 cites W2885960483 @default.
• W4229070175 cites W2980486060 @default.
• W4229070175 cites W3028065870 @default.
• W4229070175 cites W3104319202 @default.
• W4229070175 cites W3115423191 @default.
• W4229070175 cites W4376848441 @default.
• W4229070175 doi "https://doi.org/10.1016/j.jep.2022.115209" @default.
• W4229070175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35526730" @default.
• W4229070175 hasPublicationYear "2022" @default.
• W4229070175 type Work @default.
• W4229070175 citedByCount "0" @default.
• W4229070175 crossrefType "journal-article" @default.
• W4229070175 hasAuthorship W4229070175A5005553424 @default.
• W4229070175 hasAuthorship W4229070175A5009050901 @default.
• W4229070175 hasAuthorship W4229070175A5053204257 @default.
• W4229070175 hasAuthorship W4229070175A5065970192 @default.
• W4229070175 hasAuthorship W4229070175A5068735424 @default.
• W4229070175 hasAuthorship W4229070175A5082893297 @default.
• W4229070175 hasAuthorship W4229070175A5083588969 @default.
• W4229070175 hasAuthorship W4229070175A5085331622 @default.
• W4229070175 hasConcept C126322002 @default.
• W4229070175 hasConcept C29730261 @default.
• W4229070175 hasConcept C53164099 @default.
• W4229070175 hasConcept C556039675 @default.
• W4229070175 hasConcept C71924100 @default.
• W4229070175 hasConcept C81603835 @default.
• W4229070175 hasConcept C98274493 @default.
• W4229070175 hasConceptScore W4229070175C126322002 @default.
• W4229070175 hasConceptScore W4229070175C29730261 @default.
• W4229070175 hasConceptScore W4229070175C53164099 @default.
• W4229070175 hasConceptScore W4229070175C556039675 @default.
• W4229070175 hasConceptScore W4229070175C71924100 @default.
• W4229070175 hasConceptScore W4229070175C81603835 @default.
• W4229070175 hasConceptScore W4229070175C98274493 @default.
• W4229070175 hasLocation W42290701751 @default.
• W4229070175 hasLocation W42290701752 @default.
• W4229070175 hasOpenAccess W4229070175 @default.
• W4229070175 hasPrimaryLocation W42290701751 @default.
• W4229070175 hasRelatedWork W2030869928 @default.
• W4229070175 hasRelatedWork W2040006623 @default.
• W4229070175 hasRelatedWork W2043254643 @default.
• W4229070175 hasRelatedWork W2096619855 @default.
• W4229070175 hasRelatedWork W2360070380 @default.
• W4229070175 hasRelatedWork W2431487876 @default.
• W4229070175 hasRelatedWork W2462109025 @default.
• W4229070175 hasRelatedWork W2909771661 @default.
• W4229070175 hasRelatedWork W2911431277 @default.
• W4229070175 hasRelatedWork W169561904 @default.
• W4229070175 hasVolume "294" @default.
• W4229070175 isParatext "false" @default.
• W4229070175 isRetracted "false" @default.
• W4229070175 workType "article" @default.