FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229071750> ?p ?o ?g. }

• W4229071750 abstract "Abstract Funding Acknowledgements Type of funding sources: None. Background Myocardial injury is common in COVID-19, and has been linked to disease severity and mortality.1 Its pathophysiology is not fully elucidated and suggested mechanisms include cytokine damage, endotheliitis, myocarditis, ferroptosis, acute coronary syndrome, oxygen supply-demand mismatch and pulmonary embolism.2-3 Elevated serum cardiac troponin (cTn) – as surrogate marker of myocardial injury – at admission and during hospitalisation is associated with poor outcome.4-5 Comparison of available trial data, however, is unfeasible, because of variable definition and sampling timing/intervals/assays.6 Peculiarly, prognostic cut-off cTn values are often – retrospectively – set much lower than recommended by the guidelines.6-8 Furthermore, robust intensive care unit (ICU) outcome data regarding cTn evolution over time is lacking. Purpose The aim of this study is to critically explore the correlation between myocardial injury and mortality in a tertiary ICU population, using both standard and high cTn cut-off values, and to scrutinise the impact of timing and recurrence. Methods All adult COVID-19 patients admitted to our tertiary ICU between 06/03/2020 and 27/09/2021 were enrolled in this large, retrospective, single centre, cohort study. Patients requiring extracorporeal membrane oxygenation (n=29) were excluded. Myocardial injury was defined – as per ESC guidelines - as high-sensitive cardiac troponin I (hs-cTnI) peak &gt;45ng/L (99th percentile upper reference limit) and ‘major’ myocardial injury was defined as hs-cTnI &gt;135ng/L (3x upper limit of normal).6-7 Recurrent myocardial injury was considered if a new hs-cTnI peak above cut-off point occurred after normalisation. Patients were categorised according to peak (‘standard’ &gt;45ng/L vs ‘high’ &gt;135ng/L), onset (‘on admission’ vs ‘during hospitalisation’) and recurrence (‘single’ vs ‘multiple’) of hs-cTnI rise. Statistical analysis was done by logistic regression, using IBM SPSS version 28. Results A total of 193 COVID-19 ICU patients were included. Patient characteristics, disease severity indices and treatment details are summarised in Table 1. The mean age was 62 years and ICU mortality was 22%. Myocardial injury overall occurred in 51% (n=99) and major myocardial injury occurred in 39% (n=75) of patients. Obtained results were consistent across standard (&gt;45ng/L) and high (&gt;135ng/L) hs-cTnI cut-off groups. Myocardial injury only present at ICU admission was not correlated with mortality in our cohort, contradicting prior (mostly non-ICU) trials. Single hs-cTnI peak during ICU hospitalisation, however, and, especially recurrent hs-cTnI peaks were strong predictors of ICU mortality. The respective incidence, odds ratio, 95% confidence intervals and p-values are displayed in Table 2. Conclusion Myocardial injury occurring during ICU hospitalisation and, especially, recurrent myocardial injury is strongly correlated with ICU mortality in COVID-19 patients." @default.
• W4229071750 created "2022-05-08" @default.
• W4229071750 creator A5000589075 @default.
• W4229071750 creator A5003672827 @default.
• W4229071750 creator A5032329570 @default.
• W4229071750 creator A5033911279 @default.
• W4229071750 creator A5042559106 @default.
• W4229071750 creator A5056439896 @default.
• W4229071750 creator A5062759117 @default.
• W4229071750 creator A5072825660 @default.
• W4229071750 date "2022-05-01" @default.
• W4229071750 modified "2023-09-27" @default.
• W4229071750 title "Recurrent myocardial injury is a strong predictor of ICU mortality in COVID-19" @default.
• W4229071750 doi "https://doi.org/10.1093/ehjacc/zuac041.146" @default.
• W4229071750 hasPublicationYear "2022" @default.
• W4229071750 type Work @default.
• W4229071750 citedByCount "0" @default.
• W4229071750 crossrefType "journal-article" @default.
• W4229071750 hasAuthorship W4229071750A5000589075 @default.
• W4229071750 hasAuthorship W4229071750A5003672827 @default.
• W4229071750 hasAuthorship W4229071750A5032329570 @default.
• W4229071750 hasAuthorship W4229071750A5033911279 @default.
• W4229071750 hasAuthorship W4229071750A5042559106 @default.
• W4229071750 hasAuthorship W4229071750A5056439896 @default.
• W4229071750 hasAuthorship W4229071750A5062759117 @default.
• W4229071750 hasAuthorship W4229071750A5072825660 @default.
• W4229071750 hasBestOaLocation W42290717501 @default.
• W4229071750 hasConcept C115725540 @default.
• W4229071750 hasConcept C126322002 @default.
• W4229071750 hasConcept C164705383 @default.
• W4229071750 hasConcept C167135981 @default.
• W4229071750 hasConcept C2776376669 @default.
• W4229071750 hasConcept C2776858399 @default.
• W4229071750 hasConcept C2778213512 @default.
• W4229071750 hasConcept C2780875844 @default.
• W4229071750 hasConcept C2908647359 @default.
• W4229071750 hasConcept C36036425 @default.
• W4229071750 hasConcept C500558357 @default.
• W4229071750 hasConcept C71924100 @default.
• W4229071750 hasConcept C99454951 @default.
• W4229071750 hasConceptScore W4229071750C115725540 @default.
• W4229071750 hasConceptScore W4229071750C126322002 @default.
• W4229071750 hasConceptScore W4229071750C164705383 @default.
• W4229071750 hasConceptScore W4229071750C167135981 @default.
• W4229071750 hasConceptScore W4229071750C2776376669 @default.
• W4229071750 hasConceptScore W4229071750C2776858399 @default.
• W4229071750 hasConceptScore W4229071750C2778213512 @default.
• W4229071750 hasConceptScore W4229071750C2780875844 @default.
• W4229071750 hasConceptScore W4229071750C2908647359 @default.
• W4229071750 hasConceptScore W4229071750C36036425 @default.
• W4229071750 hasConceptScore W4229071750C500558357 @default.
• W4229071750 hasConceptScore W4229071750C71924100 @default.
• W4229071750 hasConceptScore W4229071750C99454951 @default.
• W4229071750 hasIssue "Supplement_1" @default.
• W4229071750 hasLocation W42290717501 @default.
• W4229071750 hasOpenAccess W4229071750 @default.
• W4229071750 hasPrimaryLocation W42290717501 @default.
• W4229071750 hasRelatedWork W1971670098 @default.
• W4229071750 hasRelatedWork W2601165163 @default.
• W4229071750 hasRelatedWork W2905002600 @default.
• W4229071750 hasRelatedWork W2919033046 @default.
• W4229071750 hasRelatedWork W2920052035 @default.
• W4229071750 hasRelatedWork W3013449988 @default.
• W4229071750 hasRelatedWork W4289535533 @default.
• W4229071750 hasRelatedWork W4319293816 @default.
• W4229071750 hasRelatedWork W4327895143 @default.
• W4229071750 hasRelatedWork W4366601963 @default.
• W4229071750 hasVolume "11" @default.
• W4229071750 isParatext "false" @default.
• W4229071750 isRetracted "false" @default.
• W4229071750 workType "article" @default.