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- W4229073754 abstract "Sulforaphane, a natural phytochemical compound found in various cruciferous vegetables, has been discovered to present anti-cancer properties. Matrix metalloproteinase-9 (MMP-9) plays a crucial role in gastric cancer metastasis. However, the role of sulforaphane in MMP-9 expression in gastric cancer is not yet defined. Nicotine, a psychoactive alkaloid found in tobacco, is associated with the development of gastric cancer. Here, we found that sulforaphane suppresses the nicotine-mediated induction of MMP-9 in human gastric cancer cells. We discovered that reactive oxygen species (ROS) and MAPKs (p38 MAPK, Erk1/2) are involved in nicotine-induced MMP-9 expression. AP-1 and NF-κB are the critical transcription factors in MMP-9 expression. ROS/MAPK (p38 MAPK, Erk1/2) and ROS functioned as upstream signaling of AP-1 and NF-κB, respectively. Sulforaphane suppresses the nicotine-induced MMP-9 by inhibiting ROS-mediated MAPK (p38 MAPK, Erk1/2)/AP-1 and ROS-mediated NF-κB signaling axes, which in turn inhibit cell invasion in human gastric cancer AGS cells. Therefore, the current study provides valuable evidence for developing sulforaphane as a new anti-invasion strategy for human gastric cancer therapy." @default.
- W4229073754 created "2022-05-08" @default.
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- W4229073754 date "2022-05-05" @default.
- W4229073754 modified "2023-10-10" @default.
- W4229073754 title "Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-κB Signaling in Human Gastric Cancer Cells" @default.
- W4229073754 cites W1588554328 @default.
- W4229073754 cites W176613604 @default.
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- W4229073754 cites W1969604938 @default.
- W4229073754 cites W1976208151 @default.
- W4229073754 cites W1983609115 @default.
- W4229073754 cites W1998212619 @default.
- W4229073754 cites W2002547764 @default.
- W4229073754 cites W2003633448 @default.
- W4229073754 cites W2005400237 @default.
- W4229073754 cites W2011569383 @default.
- W4229073754 cites W2013375670 @default.
- W4229073754 cites W2021134993 @default.
- W4229073754 cites W2021861995 @default.
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- W4229073754 cites W2040129525 @default.
- W4229073754 cites W2040470926 @default.
- W4229073754 cites W2041435471 @default.
- W4229073754 cites W2053566746 @default.
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- W4229073754 doi "https://doi.org/10.3390/ijms23095172" @default.
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