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- W4229076145 endingPage "102282" @default.
- W4229076145 startingPage "102282" @default.
- W4229076145 abstract "Once widely considered an immune-privileged organ, the brain is now known to be intimately intertwined with immune-system activation. In particular, the complement system, an enzymatic cascade conferring innate immunity, has crucial functions for several neurodevelopmental and neuromigratory mechanisms. Recent advances have demonstrated the neurological importance of complement activation in the adult brain, whereby phagocytosis of weakened synapses biologically encodes forgetting of information through complement activation. Neurophysiologically, complement factors can also influence the brain's computational processes, increasing neuronal calcium influx and neurotransmitter release and altering synaptic strength. The complement system's effects on synaptic connectivity can also be observed in many pathological conditions including epilepsy, schizophrenia, and viral-induced cognitive deficits, where perturbations of complement-stimulated synaptic remodelling lead to severe dysfunction. In this review we provide an overview of current knowledge for complement in neurodevelopment, and examine recent evidence highlighting a critical physiological role of complement in the plasticity of the adult brain. This is especially relevant due to the explosion of complement-targeted therapeutics in clinical trials to treat neurological disorders." @default.
- W4229076145 created "2022-05-08" @default.
- W4229076145 creator A5000549309 @default.
- W4229076145 creator A5033296727 @default.
- W4229076145 creator A5041408110 @default.
- W4229076145 date "2022-07-01" @default.
- W4229076145 modified "2023-10-16" @default.
- W4229076145 title "Complement drives circuit modulation in the adult brain" @default.
- W4229076145 cites W1448114976 @default.
- W4229076145 cites W1456373634 @default.
- W4229076145 cites W1486365785 @default.
- W4229076145 cites W1516567447 @default.
- W4229076145 cites W1528278198 @default.
- W4229076145 cites W1530933431 @default.
- W4229076145 cites W1567194265 @default.
- W4229076145 cites W1567432487 @default.
- W4229076145 cites W1748516712 @default.
- W4229076145 cites W1800839404 @default.
- W4229076145 cites W1896345432 @default.
- W4229076145 cites W1919495767 @default.
- W4229076145 cites W1928647053 @default.
- W4229076145 cites W1941186790 @default.
- W4229076145 cites W1970504014 @default.
- W4229076145 cites W1970816982 @default.
- W4229076145 cites W1973816954 @default.
- W4229076145 cites W1978747157 @default.
- W4229076145 cites W1980219722 @default.
- W4229076145 cites W1980789245 @default.
- W4229076145 cites W1981692914 @default.
- W4229076145 cites W1982912347 @default.
- W4229076145 cites W1988012050 @default.
- W4229076145 cites W1988652098 @default.
- W4229076145 cites W1990535528 @default.
- W4229076145 cites W1992780981 @default.
- W4229076145 cites W1994852479 @default.
- W4229076145 cites W1996868603 @default.
- W4229076145 cites W1997223338 @default.
- W4229076145 cites W1997258848 @default.
- W4229076145 cites W1999393607 @default.
- W4229076145 cites W2000854765 @default.
- W4229076145 cites W2007162991 @default.
- W4229076145 cites W2007705388 @default.
- W4229076145 cites W2008374289 @default.
- W4229076145 cites W2011041653 @default.
- W4229076145 cites W2019219375 @default.
- W4229076145 cites W2021939646 @default.
- W4229076145 cites W2022777558 @default.
- W4229076145 cites W2026017209 @default.
- W4229076145 cites W2026397702 @default.
- W4229076145 cites W2026434473 @default.
- W4229076145 cites W2028341181 @default.
- W4229076145 cites W2033617297 @default.
- W4229076145 cites W2034182762 @default.
- W4229076145 cites W2036051665 @default.
- W4229076145 cites W2037484801 @default.
- W4229076145 cites W2042777883 @default.
- W4229076145 cites W2048591661 @default.
- W4229076145 cites W2050217807 @default.
- W4229076145 cites W2052766317 @default.
- W4229076145 cites W2052995322 @default.
- W4229076145 cites W2056951760 @default.
- W4229076145 cites W2057569198 @default.
- W4229076145 cites W2070576387 @default.
- W4229076145 cites W2075997182 @default.
- W4229076145 cites W2077506189 @default.
- W4229076145 cites W2077859091 @default.
- W4229076145 cites W2078083464 @default.
- W4229076145 cites W2079668152 @default.
- W4229076145 cites W2079759085 @default.
- W4229076145 cites W2083054478 @default.
- W4229076145 cites W2086561530 @default.
- W4229076145 cites W2089178397 @default.
- W4229076145 cites W2089403382 @default.
- W4229076145 cites W2089964041 @default.
- W4229076145 cites W2092833488 @default.
- W4229076145 cites W2092935640 @default.
- W4229076145 cites W2096327192 @default.
- W4229076145 cites W2097222143 @default.
- W4229076145 cites W2102714741 @default.
- W4229076145 cites W2113380984 @default.
- W4229076145 cites W2118650749 @default.
- W4229076145 cites W2120745993 @default.
- W4229076145 cites W2126878361 @default.
- W4229076145 cites W2132665267 @default.
- W4229076145 cites W2135266046 @default.
- W4229076145 cites W2138399463 @default.
- W4229076145 cites W2141974801 @default.
- W4229076145 cites W2147698308 @default.
- W4229076145 cites W2148129999 @default.
- W4229076145 cites W2148133961 @default.
- W4229076145 cites W2154745705 @default.
- W4229076145 cites W2157710399 @default.
- W4229076145 cites W2161456882 @default.
- W4229076145 cites W2164511273 @default.
- W4229076145 cites W2168479296 @default.
- W4229076145 cites W2169551123 @default.
- W4229076145 cites W2170107264 @default.
- W4229076145 cites W2176407983 @default.