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- W4229081680 abstract "Cancer cells undergo significant metabolic remodeling to provide sufficient ATP to maintain cell survival and to promote rapid growth. In colorectal cancer cells, ATP is produced by mitochondrial oxidative phosphorylation and by substantially elevated cytoplasmic glucose fermentation (i.e., the Warburg effect). Glucose transporter 1 (GLUT1) expression is significantly increased in colorectal cancer cells, and GLUT1 inhibitors block glucose uptake and hence glycolysis crucial for cancer cell growth. In addition to ATP, these metabolic pathways also provide macromolecule building blocks and signaling molecules required for tumor growth. In this study, we identify a diaminobutoxy-substituted isoflavonoid (DBI-1) that inhibits mitochondrial complex I and deprives rapidly growing cancer cells of energy needed for growth. DBI-1 and the GLUT1 inhibitor, BAY-876, synergistically inhibit colorectal cancer cell growth in vitro and in vivo. This study suggests that an electron transport chain inhibitor (i.e., DBI-1) and a glucose transport inhibitor, (i.e., BAY-876) are potentially effective combination for colorectal cancer treatment." @default.
- W4229081680 created "2022-05-08" @default.
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- W4229081680 date "2022-02-28" @default.
- W4229081680 modified "2023-09-26" @default.
- W4229081680 title "Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells" @default.
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- W4229081680 cites W1964413125 @default.
- W4229081680 cites W1971859682 @default.
- W4229081680 cites W1978978516 @default.
- W4229081680 cites W2000846273 @default.
- W4229081680 cites W2001804808 @default.
- W4229081680 cites W2022109802 @default.
- W4229081680 cites W2026967508 @default.
- W4229081680 cites W2042287365 @default.
- W4229081680 cites W2052543023 @default.
- W4229081680 cites W2064937340 @default.
- W4229081680 cites W2074847845 @default.
- W4229081680 cites W2083814145 @default.
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- W4229081680 cites W2153737848 @default.
- W4229081680 cites W2154024364 @default.
- W4229081680 cites W2157655280 @default.
- W4229081680 cites W2161225294 @default.
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- W4229081680 cites W2176791592 @default.
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- W4229081680 cites W2234115940 @default.
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- W4229081680 cites W2279740398 @default.
- W4229081680 cites W2295060570 @default.
- W4229081680 cites W2321338941 @default.
- W4229081680 cites W2395626624 @default.
- W4229081680 cites W2517194940 @default.
- W4229081680 cites W2583960272 @default.
- W4229081680 cites W2604140695 @default.
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- W4229081680 cites W2808391024 @default.
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- W4229081680 cites W2907710771 @default.
- W4229081680 cites W2940638204 @default.
- W4229081680 cites W2943489129 @default.
- W4229081680 cites W2949150764 @default.
- W4229081680 cites W2949786959 @default.
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- W4229081680 doi "https://doi.org/10.1158/1535-7163.mct-21-0925" @default.
- W4229081680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35247917" @default.
- W4229081680 hasPublicationYear "2022" @default.
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