FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229082034> ?p ?o ?g. }

• W4229082034 endingPage "7364" @default.
• W4229082034 startingPage "7354" @default.
• W4229082034 abstract "Abstract Objectives As described recently, intravenously injected gadolinium-based contrast agent (GBCA) penetrates into the anterior eye chamber (AC) and is drained from the retina to the distal optic nerve (ON) along perivascular spaces, which serves retinal homeostasis and was termed the orbital glymphatic system (GS). Independently, AC enhancement predicted ON infiltration, a major risk factor for advanced retinoblastoma (RB), in a small RB patient cohort. We aimed to review the supposed imaging biomarker for ON infiltration in a large RB cohort and with respect to the recently described orbital GS. Methods This IRB–approved retrospective single-center study encompassed 539 orbital MRIs performed with an orbital coil and with the children under general anesthesia. Differences of signal intensity ratios (∆SIRs) of the AC to the lens were determined between non-contrast and GBCA–enhanced T1-weighted images and were correlated with histopathologic presence of ON infiltration. Results ∆SIR of the RB eye was an independent, significant predictor for ON invasion in multivariate analysis with adjustment for tumor size ( p < 0.05) and increased with infiltration level. Conclusions GBCA enhancement of the AC predicts ON infiltration. This might be caused by impairment of the orbital glymphatic system, which is supposed to clear toxic metabolites from the retina to the postlaminar ON. In RB with ON infiltration, this efflux path is likely to be inhibited, which is supposed to result in disturbed retinal homeostasis, release of vascular endothelial growth factor, and iris neovascularization, which increases penetration of GBCA into the AC. Key Points • Infiltration of the optic nerve can be predicted by anterior chamber enhancement after intravenous MRI contrast agent administration. • Increased anterior chamber enhancement in retinoblastoma with optic nerve infiltration might result from dysfunction of the orbital glymphatic system with disturbance of retinal homeostasis and consecutive iris neovascularization." @default.
• W4229082034 created "2022-05-08" @default.
• W4229082034 creator A5005295293 @default.
• W4229082034 creator A5010541584 @default.
• W4229082034 creator A5030508124 @default.
• W4229082034 creator A5044080081 @default.
• W4229082034 creator A5046483118 @default.
• W4229082034 creator A5049150526 @default.
• W4229082034 creator A5076786068 @default.
• W4229082034 creator A5079084775 @default.
• W4229082034 creator A5084473005 @default.
• W4229082034 date "2022-05-07" @default.
• W4229082034 modified "2023-10-18" @default.
• W4229082034 title "Anterior chamber enhancement predicts optic nerve infiltration in retinoblastoma" @default.
• W4229082034 cites W1989632929 @default.
• W4229082034 cites W2024148516 @default.
• W4229082034 cites W2026330931 @default.
• W4229082034 cites W2031848163 @default.
• W4229082034 cites W2060630205 @default.
• W4229082034 cites W2067210593 @default.
• W4229082034 cites W2069339449 @default.
• W4229082034 cites W2076890468 @default.
• W4229082034 cites W2110107008 @default.
• W4229082034 cites W2138830799 @default.
• W4229082034 cites W2146472373 @default.
• W4229082034 cites W2156014412 @default.
• W4229082034 cites W2158430122 @default.
• W4229082034 cites W2163623189 @default.
• W4229082034 cites W2165600074 @default.
• W4229082034 cites W2172143109 @default.
• W4229082034 cites W2532532476 @default.
• W4229082034 cites W2556878797 @default.
• W4229082034 cites W2596313689 @default.
• W4229082034 cites W2741571643 @default.
• W4229082034 cites W2744943383 @default.
• W4229082034 cites W2801213291 @default.
• W4229082034 cites W2901576084 @default.
• W4229082034 cites W2981280146 @default.
• W4229082034 cites W2989603343 @default.
• W4229082034 cites W3010770528 @default.
• W4229082034 cites W3013081630 @default.
• W4229082034 cites W3096082538 @default.
• W4229082034 cites W3131369509 @default.
• W4229082034 doi "https://doi.org/10.1007/s00330-022-08778-4" @default.
• W4229082034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35524782" @default.
• W4229082034 hasPublicationYear "2022" @default.
• W4229082034 type Work @default.
• W4229082034 citedByCount "3" @default.
• W4229082034 countsByYear W42290820342022 @default.
• W4229082034 countsByYear W42290820342023 @default.
• W4229082034 crossrefType "journal-article" @default.
• W4229082034 hasAuthorship W4229082034A5005295293 @default.
• W4229082034 hasAuthorship W4229082034A5010541584 @default.
• W4229082034 hasAuthorship W4229082034A5030508124 @default.
• W4229082034 hasAuthorship W4229082034A5044080081 @default.
• W4229082034 hasAuthorship W4229082034A5046483118 @default.
• W4229082034 hasAuthorship W4229082034A5049150526 @default.
• W4229082034 hasAuthorship W4229082034A5076786068 @default.
• W4229082034 hasAuthorship W4229082034A5079084775 @default.
• W4229082034 hasAuthorship W4229082034A5084473005 @default.
• W4229082034 hasBestOaLocation W42290820341 @default.
• W4229082034 hasConcept C101054994 @default.
• W4229082034 hasConcept C118487528 @default.
• W4229082034 hasConcept C118552586 @default.
• W4229082034 hasConcept C121332964 @default.
• W4229082034 hasConcept C126838900 @default.
• W4229082034 hasConcept C142724271 @default.
• W4229082034 hasConcept C143409427 @default.
• W4229082034 hasConcept C153400128 @default.
• W4229082034 hasConcept C16568411 @default.
• W4229082034 hasConcept C2779651940 @default.
• W4229082034 hasConcept C2779889316 @default.
• W4229082034 hasConcept C2780827179 @default.
• W4229082034 hasConcept C2780837183 @default.
• W4229082034 hasConcept C513090587 @default.
• W4229082034 hasConcept C71924100 @default.
• W4229082034 hasConcept C97355855 @default.
• W4229082034 hasConceptScore W4229082034C101054994 @default.
• W4229082034 hasConceptScore W4229082034C118487528 @default.
• W4229082034 hasConceptScore W4229082034C118552586 @default.
• W4229082034 hasConceptScore W4229082034C121332964 @default.
• W4229082034 hasConceptScore W4229082034C126838900 @default.
• W4229082034 hasConceptScore W4229082034C142724271 @default.
• W4229082034 hasConceptScore W4229082034C143409427 @default.
• W4229082034 hasConceptScore W4229082034C153400128 @default.
• W4229082034 hasConceptScore W4229082034C16568411 @default.
• W4229082034 hasConceptScore W4229082034C2779651940 @default.
• W4229082034 hasConceptScore W4229082034C2779889316 @default.
• W4229082034 hasConceptScore W4229082034C2780827179 @default.
• W4229082034 hasConceptScore W4229082034C2780837183 @default.
• W4229082034 hasConceptScore W4229082034C513090587 @default.
• W4229082034 hasConceptScore W4229082034C71924100 @default.
• W4229082034 hasConceptScore W4229082034C97355855 @default.
• W4229082034 hasIssue "11" @default.
• W4229082034 hasLocation W42290820341 @default.
• W4229082034 hasLocation W42290820342 @default.
• W4229082034 hasLocation W42290820343 @default.
• W4229082034 hasOpenAccess W4229082034 @default.

• next