Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229083708> ?p ?o ?g. }
- W4229083708 abstract "The flexible adjustment of ongoing behavior challenges the nervous system's dynamic control mechanisms and has shown to be specifically susceptible to age-related decline. Previous work links endogenous gamma-aminobutyric acid (GABA) with behavioral efficiency across perceptual and cognitive domains, with potentially the strongest impact on those behaviors that require a high level of dynamic control. Our analysis integrated behavior and modulation of interhemispheric phase-based connectivity during dynamic motor-state transitions with endogenous GABA concentration in adult human volunteers. We provide converging evidence for age-related differences in the preferred state of endogenous GABA concentration for more flexible behavior. We suggest that the increased interhemispheric connectivity observed in the older participants represents a compensatory neural mechanism caused by phase-entrainment in homotopic motor cortices. This mechanism appears to be most relevant in the presence of a less optimal tuning of the inhibitory tone as observed during healthy aging to uphold the required flexibility of behavioral action. Future work needs to validate the relevance of this interplay between neural connectivity and GABAergic inhibition for other domains of flexible human behavior." @default.
- W4229083708 created "2022-05-08" @default.
- W4229083708 creator A5024490605 @default.
- W4229083708 creator A5039429080 @default.
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- W4229083708 creator A5087399037 @default.
- W4229083708 creator A5088503866 @default.
- W4229083708 date "2022-05-06" @default.
- W4229083708 modified "2023-10-10" @default.
- W4229083708 title "The interaction between endogenous GABA, functional connectivity, and behavioral flexibility is critically altered with advanced age" @default.
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