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• W4229331770 endingPage "103038" @default.
• W4229331770 startingPage "103038" @default.
• W4229331770 abstract "Aphasia is one of the most common causes of post-stroke disabilities. As the symptoms and impact of post-stroke aphasia are heterogeneous, it is important to understand how topographical lesion heterogeneity in patients with aphasia is associated with different domains of language impairments. Here, we aim to provide a comprehensive overview of neuroanatomical basis in post-stroke aphasia through coordinate based meta-analysis of voxel-based lesion-symptom mapping studies. We performed a meta-analysis of lesion-symptom mapping studies in post-stroke aphasia. We obtained coordinate-based structural neuroimaging data for 2,007 individuals with aphasia from 25 studies that met predefined inclusion criteria. Overall, our results revealed that the distinctive patterns of lesions in aphasia are associated with different language functions and tasks. Damage to the insular-motor areas impaired speech with preserved comprehension and a similar pattern was observed when the lesion covered the insular-motor and inferior parietal lobule. Lesions in the frontal area severely impaired speaking with relatively good comprehension. The repetition-selective deficits only arise from lesions involving the posterior superior temporal gyrus. Damage in the anterior-to-posterior temporal cortex was associated with semantic deficits. The association patterns of lesion topography and specific language deficits provide key insights into the specific underlying language pathways. Our meta-analysis results strongly support the dual pathway model of language processing, capturing the link between the different symptom complexes of aphasias and the different underlying location of damage." @default.
• W4229331770 created "2022-05-09" @default.
• W4229331770 creator A5061070318 @default.
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• W4229331770 creator A5064633866 @default.
• W4229331770 creator A5086835499 @default.
• W4229331770 date "2022-01-01" @default.
• W4229331770 modified "2023-10-17" @default.
• W4229331770 title "Language systems from lesion-symptom mapping in aphasia: A meta-analysis of voxel-based lesion mapping studies" @default.
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• W4229331770 doi "https://doi.org/10.1016/j.nicl.2022.103038" @default.
• W4229331770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35569227" @default.
• W4229331770 hasPublicationYear "2022" @default.
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