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- W4229333130 abstract "Elevation of soluble wild-type (WT) tau occurs in synaptic compartments in Alzheimer's disease. We addressed whether tau elevation affects synaptic transmission at the calyx of Held in slices from mice brainstem. Whole-cell loading of WT human tau (h-tau) in presynaptic terminals at 10-20 µM caused microtubule (MT) assembly and activity-dependent rundown of excitatory neurotransmission. Capacitance measurements revealed that the primary target of WT h-tau is vesicle endocytosis. Blocking MT assembly using nocodazole prevented tau-induced impairments of endocytosis and neurotransmission. Immunofluorescence imaging analyses revealed that MT assembly by WT h-tau loading was associated with an increased MT-bound fraction of the endocytic protein dynamin. A synthetic dodecapeptide corresponding to dynamin 1-pleckstrin-homology domain inhibited MT-dynamin interaction and rescued tau-induced impairments of endocytosis and neurotransmission. We conclude that elevation of presynaptic WT tau induces de novo assembly of MTs, thereby sequestering free dynamins. As a result, endocytosis and subsequent vesicle replenishment are impaired, causing activity-dependent rundown of neurotransmission." @default.
- W4229333130 created "2022-05-09" @default.
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- W4229333130 date "2022-04-26" @default.
- W4229333130 modified "2023-09-25" @default.
- W4229333130 title "Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model" @default.
- W4229333130 cites W1585616862 @default.
- W4229333130 cites W1600812038 @default.
- W4229333130 cites W1733355263 @default.
- W4229333130 cites W1927347955 @default.
- W4229333130 cites W1968937229 @default.
- W4229333130 cites W1970686195 @default.
- W4229333130 cites W1975321314 @default.
- W4229333130 cites W1978627586 @default.
- W4229333130 cites W1984939118 @default.
- W4229333130 cites W1986744284 @default.
- W4229333130 cites W1987749939 @default.
- W4229333130 cites W1988884999 @default.
- W4229333130 cites W1993706961 @default.
- W4229333130 cites W1994030229 @default.
- W4229333130 cites W1994336523 @default.
- W4229333130 cites W1996715055 @default.
- W4229333130 cites W1998307422 @default.
- W4229333130 cites W2005755021 @default.
- W4229333130 cites W2006999571 @default.
- W4229333130 cites W2013327420 @default.
- W4229333130 cites W2013902743 @default.
- W4229333130 cites W2017151574 @default.
- W4229333130 cites W2018945212 @default.
- W4229333130 cites W2020815630 @default.
- W4229333130 cites W2021370614 @default.
- W4229333130 cites W2022532556 @default.
- W4229333130 cites W2027670444 @default.
- W4229333130 cites W2030602441 @default.
- W4229333130 cites W2034286717 @default.
- W4229333130 cites W2036755018 @default.
- W4229333130 cites W2038622174 @default.
- W4229333130 cites W2039313004 @default.
- W4229333130 cites W2039468514 @default.
- W4229333130 cites W2040124514 @default.
- W4229333130 cites W2041679548 @default.
- W4229333130 cites W2042527044 @default.
- W4229333130 cites W2043661712 @default.
- W4229333130 cites W2053082937 @default.
- W4229333130 cites W2054922048 @default.
- W4229333130 cites W2057249855 @default.
- W4229333130 cites W2059127030 @default.
- W4229333130 cites W2060904588 @default.
- W4229333130 cites W2061538653 @default.
- W4229333130 cites W2064244929 @default.
- W4229333130 cites W2066011396 @default.
- W4229333130 cites W2068011527 @default.
- W4229333130 cites W2075421841 @default.
- W4229333130 cites W2082429191 @default.
- W4229333130 cites W2088133560 @default.
- W4229333130 cites W2095963715 @default.
- W4229333130 cites W2096938747 @default.
- W4229333130 cites W2116186338 @default.
- W4229333130 cites W2117526022 @default.
- W4229333130 cites W2125985978 @default.
- W4229333130 cites W2134157741 @default.
- W4229333130 cites W2135309154 @default.
- W4229333130 cites W2136922708 @default.
- W4229333130 cites W2137140827 @default.
- W4229333130 cites W2137326161 @default.
- W4229333130 cites W2142349607 @default.
- W4229333130 cites W2143997699 @default.
- W4229333130 cites W2144925005 @default.
- W4229333130 cites W2146714497 @default.
- W4229333130 cites W2167511682 @default.
- W4229333130 cites W2497972376 @default.
- W4229333130 cites W2539044678 @default.
- W4229333130 cites W2548432647 @default.
- W4229333130 cites W2590662729 @default.
- W4229333130 cites W2605036205 @default.
- W4229333130 cites W2613492737 @default.
- W4229333130 cites W2621339407 @default.
- W4229333130 cites W2785931320 @default.
- W4229333130 cites W2809799315 @default.
- W4229333130 cites W2887032631 @default.
- W4229333130 cites W2899845345 @default.
- W4229333130 cites W2990404194 @default.
- W4229333130 cites W3019386172 @default.
- W4229333130 cites W3093220931 @default.
- W4229333130 doi "https://doi.org/10.7554/elife.73542" @default.
- W4229333130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35471147" @default.
- W4229333130 hasPublicationYear "2022" @default.
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