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• W4229363463 abstract "Epigenetic regulation is integral in orchestrating the spatiotemporal regulation of gene expression which underlies tissue development. The emergence of new tools to assess genome-wide epigenetic modifications has enabled significant advances in the field of vascular biology in zebrafish. Zebrafish represents a powerful model to investigate the activity of cis -regulatory elements in vivo by combining technologies such as ATAC-seq, ChIP-seq and CUT&amp;Tag with the generation of transgenic lines and live imaging to validate the activity of these regulatory elements. Recently, this approach led to the identification and characterization of key enhancers of important vascular genes, such as gata2a, notch1b and dll4 . In this review we will discuss how the latest technologies in epigenetics are being used in the zebrafish to determine chromatin states and assess the function of the cis -regulatory sequences that shape the zebrafish vascular network." @default.
• W4229363463 created "2022-05-10" @default.
• W4229363463 creator A5057751537 @default.
• W4229363463 creator A5068869985 @default.
• W4229363463 creator A5087800526 @default.
• W4229363463 date "2022-05-09" @default.
• W4229363463 modified "2023-10-14" @default.
• W4229363463 title "Epigenetic Regulation of Endothelial Cell Lineages During Zebrafish Development—New Insights From Technical Advances" @default.
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