FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229365059> ?p ?o ?g. }

• W4229365059 abstract "Abstract Critical sized cartilage defects heal poorly and MSC-based therapies holds promise functional cartilage regeneration either used alone or in combination with growth factors. However, Recombinant protein growth factors were proven to have minimal benefits while to have adverse side effects and high cost. Nonviral mRNA delivery provides a promising, alternative approach to delivering therapeutic proteins within defect lesion for an extended period of time. Despite successful therapeutic outcome in bone and other vascularized tissues, the therapeutic application of mRNA in poorly vascularized tissues such as cartilage is still facing many challenges and rarely studied. We report here using chemically modified messenger RNA encoding TGF-β3(TGF-β3 cmRNA) to enhance the therapeutic efficacy of BMSCs to efficient repair of cartilage defect. Local administration of TGF-β3 cmRNA enhanced BMSCs therapy restored critical-sized cartilage defects in situ in a rat model within 6 weeks with structural and molecular markers similar to its nature counterparts. In addition, the development of osteoarthritis caused by cartilage damage was prevented by this mRNA-enhanced BMSCs therapy evidenced by minimal late-stage OA pharmacological presentations. This novel mRNA enhanced-MSC technology extend the development of new therapeutic approaches for treating functional cartilage repair." @default.
• W4229365059 created "2022-05-10" @default.
• W4229365059 creator A5002593558 @default.
• W4229365059 creator A5016262940 @default.
• W4229365059 creator A5030921116 @default.
• W4229365059 creator A5035880695 @default.
• W4229365059 creator A5036726873 @default.
• W4229365059 creator A5039286395 @default.
• W4229365059 creator A5054709496 @default.
• W4229365059 creator A5064623806 @default.
• W4229365059 creator A5080280424 @default.
• W4229365059 creator A5080348326 @default.
• W4229365059 creator A5082089959 @default.
• W4229365059 creator A5087313633 @default.
• W4229365059 date "2022-05-06" @default.
• W4229365059 modified "2023-10-12" @default.
• W4229365059 title "Highly efficient healing of critical sized articular cartilage defect in situ using a chemically nucleoside-modified mRNA-enhanced cell therapy" @default.
• W4229365059 cites W1957489746 @default.
• W4229365059 cites W1963706689 @default.
• W4229365059 cites W2025980739 @default.
• W4229365059 cites W2035226186 @default.
• W4229365059 cites W2041401385 @default.
• W4229365059 cites W2055670245 @default.
• W4229365059 cites W2065398254 @default.
• W4229365059 cites W2065765779 @default.
• W4229365059 cites W2074645659 @default.
• W4229365059 cites W2077531877 @default.
• W4229365059 cites W2084694220 @default.
• W4229365059 cites W2098188264 @default.
• W4229365059 cites W2098419906 @default.
• W4229365059 cites W2108344016 @default.
• W4229365059 cites W2117632097 @default.
• W4229365059 cites W2130629739 @default.
• W4229365059 cites W2159999899 @default.
• W4229365059 cites W2434565902 @default.
• W4229365059 cites W2587871737 @default.
• W4229365059 cites W2783022904 @default.
• W4229365059 cites W2907035923 @default.
• W4229365059 cites W2943904500 @default.
• W4229365059 cites W2951233129 @default.
• W4229365059 cites W2952248722 @default.
• W4229365059 cites W2998402306 @default.
• W4229365059 cites W3007938849 @default.
• W4229365059 cites W3093617357 @default.
• W4229365059 cites W3111255098 @default.
• W4229365059 cites W3167136529 @default.
• W4229365059 cites W4205483821 @default.
• W4229365059 cites W4207051048 @default.
• W4229365059 cites W4207068215 @default.
• W4229365059 cites W4224285902 @default.
• W4229365059 doi "https://doi.org/10.1101/2022.05.06.490932" @default.
• W4229365059 hasPublicationYear "2022" @default.
• W4229365059 type Work @default.
• W4229365059 citedByCount "2" @default.
• W4229365059 countsByYear W42293650592022 @default.
• W4229365059 crossrefType "posted-content" @default.
• W4229365059 hasAuthorship W4229365059A5002593558 @default.
• W4229365059 hasAuthorship W4229365059A5016262940 @default.
• W4229365059 hasAuthorship W4229365059A5030921116 @default.
• W4229365059 hasAuthorship W4229365059A5035880695 @default.
• W4229365059 hasAuthorship W4229365059A5036726873 @default.
• W4229365059 hasAuthorship W4229365059A5039286395 @default.
• W4229365059 hasAuthorship W4229365059A5054709496 @default.
• W4229365059 hasAuthorship W4229365059A5064623806 @default.
• W4229365059 hasAuthorship W4229365059A5080280424 @default.
• W4229365059 hasAuthorship W4229365059A5080348326 @default.
• W4229365059 hasAuthorship W4229365059A5082089959 @default.
• W4229365059 hasAuthorship W4229365059A5087313633 @default.
• W4229365059 hasBestOaLocation W42293650591 @default.
• W4229365059 hasConcept C104317684 @default.
• W4229365059 hasConcept C105580179 @default.
• W4229365059 hasConcept C105702510 @default.
• W4229365059 hasConcept C142724271 @default.
• W4229365059 hasConcept C149364088 @default.
• W4229365059 hasConcept C171056886 @default.
• W4229365059 hasConcept C185592680 @default.
• W4229365059 hasConcept C204787440 @default.
• W4229365059 hasConcept C2776164576 @default.
• W4229365059 hasConcept C2780550940 @default.
• W4229365059 hasConcept C502942594 @default.
• W4229365059 hasConcept C55493867 @default.
• W4229365059 hasConcept C60644358 @default.
• W4229365059 hasConcept C71924100 @default.
• W4229365059 hasConcept C86803240 @default.
• W4229365059 hasConcept C95444343 @default.
• W4229365059 hasConcept C98274493 @default.
• W4229365059 hasConceptScore W4229365059C104317684 @default.
• W4229365059 hasConceptScore W4229365059C105580179 @default.
• W4229365059 hasConceptScore W4229365059C105702510 @default.
• W4229365059 hasConceptScore W4229365059C142724271 @default.
• W4229365059 hasConceptScore W4229365059C149364088 @default.
• W4229365059 hasConceptScore W4229365059C171056886 @default.
• W4229365059 hasConceptScore W4229365059C185592680 @default.
• W4229365059 hasConceptScore W4229365059C204787440 @default.
• W4229365059 hasConceptScore W4229365059C2776164576 @default.
• W4229365059 hasConceptScore W4229365059C2780550940 @default.
• W4229365059 hasConceptScore W4229365059C502942594 @default.
• W4229365059 hasConceptScore W4229365059C55493867 @default.
• W4229365059 hasConceptScore W4229365059C60644358 @default.
• W4229365059 hasConceptScore W4229365059C71924100 @default.

• next