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• W4229366304 abstract "In this paper, we designed and synthesized a novel phenylazo-based fluorescent probe (RHN) for the sensing and imaging of hypochlorous acid (HClO) in mitochondria in living cells. In this process, HClO promoted the oxidation of the phenylazo group to generate a free Rhodol fluorophore moiety, which in turn restored strong fluorescence and realized the detection of HClO. As expected, RHN exhibited high selectivity, high sensitivity and rapid response, with detection limits as low as 22 nM (1.155 ng/mL). Importantly, the results of the cell imaging experiments indicated that RHN has the ability to image and sense HClO in mitochondria, which is of great significance for exploration of the specific role of HClO in both the immune system and diseases." @default.
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• W4229366304 date "2022-05-06" @default.
• W4229366304 modified "2023-09-26" @default.
• W4229366304 title "A New Phenylazo-Based Fluorescent Probe for Sensitive Detection of Hypochlorous Acid in Aqueous Solution" @default.
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• W4229366304 doi "https://doi.org/10.3390/molecules27092978" @default.
• W4229366304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35566328" @default.
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