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• W4229366852 abstract "Multimodal integration facilitates object recognition and response to sensory cues. This depends on spatiotemporal coincidence of sensory information, recruitment of NMDA-type glutamate receptors and inhibitory feedback. Shepherd's crook neurons (SCNs) in the avian optic tectum (TeO) are an ideal model for studying cellular mechanism of multimodal integration. They receive different sensory modalities through spatially segregated dendrites, are important for stimulus selection and have an axon-carrying dendrite (AcD). We performed whole-cell patch-clamp experiments in chicken midbrain slices of both sexes. We emulated visual and auditory input in vitro by stimulating presynaptic afferents electrically. Simultaneous stimulation enhanced responses inversely depending on stimulation amplitude demonstrating the principle of inverse effectiveness. Contribution of NMDA-type glutamate receptors prolonged postsynaptic events for visual inputs only, causing a strong modality-specific difference in synaptic efficacy. We designed a multicompartment model to study the effect of morphological and physiological parameters on multimodal integration by varying the distance between soma and axonal origin and the amount of NMDA receptor (NMDAR) contribution. These parameters changed the preference of the model for one input channel and adjusted the range of input rates at which multimodal enhancement occurred on naturalistic stimulation. Thus, the unique morphology and synaptic features of SCNs shape the integration of input at different dendrites and generates an enhanced multimodal response.SIGNIFICANCE STATEMENT Multimodal integration improves perception and responses to objects. The underlying cellular mechanism depends on a balance between excitation and inhibition, and NMDA-type glutamate receptors that are involved in the multiplicative nature of enhancement following the principle of inverse effectiveness. Based on a detailed analysis of an identified multimodal cell type in the vertebrate midbrain, we studied the influence of cellular morphology and unimodal synaptic properties on multimodal integration. We can show that the combination of cellular morphology and modality-specific synaptic properties including NMDA receptor (NMDAR) contribution is optimal for nonlinear, multimodal enhancement and determines the dynamic response range of the integrating neuron. Our findings mechanistically explain how synaptic properties and cellular morphology of a midbrain neuron contribute to multimodal enhancement." @default.
• W4229366852 created "2022-05-10" @default.
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• W4229366852 date "2022-02-08" @default.
• W4229366852 modified "2023-10-16" @default.
• W4229366852 title "Morphology and Dendrite-Specific Synaptic Properties of Midbrain Neurons Shape Multimodal Integration" @default.
• W4229366852 cites W1604444942 @default.
• W4229366852 cites W1613262486 @default.
• W4229366852 cites W1963026571 @default.
• W4229366852 cites W1963506013 @default.
• W4229366852 cites W1967234015 @default.
• W4229366852 cites W1967746489 @default.
• W4229366852 cites W1968180492 @default.
• W4229366852 cites W1969742740 @default.
• W4229366852 cites W1970504218 @default.
• W4229366852 cites W1970716201 @default.
• W4229366852 cites W1974122120 @default.
• W4229366852 cites W1976809315 @default.
• W4229366852 cites W1976884425 @default.
• W4229366852 cites W1986404249 @default.
• W4229366852 cites W1989123260 @default.
• W4229366852 cites W1991770977 @default.
• W4229366852 cites W1999491265 @default.
• W4229366852 cites W2000000031 @default.
• W4229366852 cites W2004374905 @default.
• W4229366852 cites W2006764394 @default.
• W4229366852 cites W2007733019 @default.
• W4229366852 cites W2008817973 @default.
• W4229366852 cites W2011569542 @default.
• W4229366852 cites W2012994257 @default.
• W4229366852 cites W2013652395 @default.
• W4229366852 cites W2020130296 @default.
• W4229366852 cites W2026076879 @default.
• W4229366852 cites W2030772363 @default.
• W4229366852 cites W2031530235 @default.
• W4229366852 cites W2037242579 @default.
• W4229366852 cites W2042698879 @default.
• W4229366852 cites W2048231513 @default.
• W4229366852 cites W2050224699 @default.
• W4229366852 cites W2051387206 @default.
• W4229366852 cites W2054473936 @default.
• W4229366852 cites W2055435414 @default.
• W4229366852 cites W2056125158 @default.
• W4229366852 cites W2057902688 @default.
• W4229366852 cites W2060344893 @default.
• W4229366852 cites W2065550726 @default.
• W4229366852 cites W2072976466 @default.
• W4229366852 cites W2080119540 @default.
• W4229366852 cites W2082973134 @default.
• W4229366852 cites W2088169677 @default.
• W4229366852 cites W2089386763 @default.
• W4229366852 cites W2094348461 @default.
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• W4229366852 cites W2111592937 @default.
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• W4229366852 cites W2156047020 @default.
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• W4229366852 cites W2168779967 @default.
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• W4229366852 doi "https://doi.org/10.1523/jneurosci.1695-21.2022" @default.
• W4229366852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35135851" @default.
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