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• W4229366950 abstract "Abstract Background hTERT promotor mutation represents a common and early event in hepatocarcinogenesis. Its linkage with the morphologic status of the underlying liver tissue is not really understood. We analysed the connection between the histopathological changes of tumour bearing liver tissue and the occurrence of hTERT promotor mutation in hepatocellular carcinoma, correlated with clinical data. Methods The study cohort comprised 160 histologically confirmed hepatocellular carcinomas (HCC) in liver cirrhosis and non-cirrhosis which were investigated for hTERT promotor mutation. Frequency of hTERT promotor mutation in HCC in cirrhosis and non-cirrhosis was evaluated and correlated with potential clinical and histopathological drivers. Especially, tumour bearing non-cirrhotic liver tissue was examined regarding inflammation, modified histological activity index (mHAI), fibrosis and steatosis and its correlation with the frequency of hTERT promotor mutation in HCC. Overall survival analysis via multivariate Cox regression analysis was performed. Furthermore, hTERT antibody immunohistochemistry and molecular hTERT promotor mutation analysis of both HCC and background liver tissue were compared. Results hTERT promotor mutation was especially related to HCC in cirrhosis compared to non-cirrhotic liver tissue ( p < 0.001) and independently from cirrhosis to HCC in patients ≥ 60 ( p = 0.005). Furthermore, hTERT promotor mutation was associated with liver cirrhosis caused by alcohol toxicity and hepatitis C virus infection (HCV). In non-cirrhotic liver tissue the frequency of hTERT promotor mutated HCC increased with the degree of inflammation and fibrosis. Nevertheless, 25% of hTERT promotor mutated HCC developed in normal liver tissue without HCC risk factors. Multivariate Cox regression analysis did not show an influence of hTERT promotor mutation in HCC on overall survival of 3, 5 and 16 years. Immunohistochemical analysis with the hTERT antibodies LS-B95 and 2D8 hTERT promotor mutated HCC and wildtype HCC showed a mildly stronger immunoreaction compared to the tumour bearing liver tissue (LS-B95: p < 0.01, 2D8: p < 0.01). Conclusions Our study reveals a connection between pathological changes of tumour bearing liver tissue and hTERT promotor mutation in most HCC, even in non-cirrhotic liver tissue. Immunohistochemical hTERT antibodies do not discriminate between hTERT promotor mutated and wildtype HCC." @default.
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• W4229366950 date "2022-05-09" @default.
• W4229366950 modified "2023-10-18" @default.
• W4229366950 title "Pathology of hepatocellular carcinoma and tumour bearing liver tissue in association with hTERT promotor mutation" @default.
• W4229366950 doi "https://doi.org/10.21203/rs.3.rs-1497955/v1" @default.
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